408,613 research outputs found
Temporal inabilities and decision-making capacity in depression
We report on an interview-based study of decision-making capacity in two classes of patients suffering from depression. Developing a method of second-person hermeneutic phenomenology, we articulate the distinctive combination of temporal agility and temporal inability characteristic of the experience of severely depressed patients. We argue that a cluster of decision-specific temporal abilities is a critical element of decision-making capacity, and we show that loss of these abilities is a risk factor distinguishing severely depressed patients from mildly/moderately depressed patients. We explore the legal and clinical consequences of this result
Metriplectic Integrators for the Landau Collision Operator
We present a novel framework for addressing the nonlinear Landau collision
integral in terms of finite element and other subspace projection methods. We
employ the underlying metriplectic structure of the Landau collision integral
and, using a Galerkin discretization for the velocity space, we transform the
infinite-dimensional system into a finite-dimensional, time-continuous
metriplectic system. Temporal discretization is accomplished using the concept
of discrete gradients. The conservation of energy, momentum, and particle
densities, as well as the production of entropy is demonstrated algebraically
for the fully discrete system. Due to the generality of our approach, the
conservation properties and the monotonic behavior of entropy are guaranteed
for finite element discretizations in general, independently of the mesh
configuration.Comment: 24 pages. Comments welcom
SpZ12-1, a negative regulator required for spatial control of the territory-specific CyIIIa gene in the sea urchin embryo
The CyIIIa cytoskeletal actin gene of the sea urchin Strongylocentrotus purpuratus is activated in late cleavage and expressed exclusively in the aboral ectoderm territory of the embryo. Previous gene transfer studies defined a 2.3 kb cis-regulatory region that is necessary and sufficient for correct temporal and spatial expression of a CyIIIa. CAT fusion gene. In this paper, a negative regulatory element within this region was identified that is required for repression of the CyIIIa gene in skeletogenic mesenchyme cells. The repression mediated by this regulatory element takes place after initial territorial specification. A cDNA clone encoding a DNA-binding protein with twelve Zn fingers (SpZ12-1) was isolated by probing an expression library with this cis-element. Deletion analysis of the SpZ12-1 protein confirmed that a DNA-binding domain is located within the Zn finger region. SpZ12-1 is the only DNA-binding protein in embryo nuclear extract that interacts with the specific cis-target sites required for repression of CyIIIa.CAT in skeletogenic mesenchyme and is likely to be the trans factor that mediates this repression
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