PaperChain: A Collaborative Healthcare System Grounded in Field Study Work

In this extended abstract we summarise our recent experiences of designing and deploying PaperChain, a system to support real-time information sharing in healthcare work. A guiding principle has been the development of a deep understanding of the work as the foundation for effective system design. We summarise the field work that motivated the development of PaperChain, some of the key findings and the resulting system. We briefly reflect on the benefits gained from undertaking substantial HCI work in the design of a healthcare system

Shaping Australia's Future

This article provides an overview of the development of the first national policy for the study of Asian langauges and cultures in the Australian education system throught the NALSAS strategy and the establishment and achievements of the Asia Education Foundation (AEF)

CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine

The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the impact of genetics on disease development by enabling the creation of precise cellular and animal models of human diseases. The therapeutic potential of these technologies is tremendous, particularly in gene therapy, in which a patient-specific mutation is genetically corrected in order to treat human diseases that are untreatable with conventional therapies. However, the translation of CRISPR/Cas9 into the clinics will be challenging, since we still need to improve the efficiency, specificity and delivery of this technology. In this review, we focus on several in vitro, in vivo and ex vivo applications of the CRISPR/Cas9 system in human disease-focused research, explore the potential of this technology in translational medicine and discuss some of the major challenges for its future use in patients.Portuguese Foundation for Science and Technology: UID/BIM/04773/2013 1334 Spanish Ministry of Science, Innovation and Universities RTI2018-094629-B-I00 Portuguese Foundation for Science and Technology SFRH/BPD/100434/2014 European Union (EU) 748585 LPCC-NRS/Terry Fox grantsinfo:eu-repo/semantics/publishedVersio

FIJICLIM description and users guide

The FIJICLIM prototype is based on PACCLIM which was developed by the International Global Change Institute (IGCI) as part of the Pacific Islands Climate Change Assistance Programme (PICCAP) executed by the South Pacific Regional Environment Programme (SPREP). Both FIJICLIM and PACCLIM build directly on a comparable model development for New Zealand, known as the CLIMPACTS system (Kenny et al., 1995, 1999; Warrick et al., 1996, 1999). The development of CLIMPACTS has been funded by the Foundation for Research Science and Technology since 1993. Its core components, which include a graphic user interface (GUI), a customised geographic information system (GIS), and data compression routines, have provided the basis for the development of FIJICLIM. The development of FIJICLIM is complementary to similar developments that have evolved from CLIMPACTS, for Bangladesh (BDCLIM), Australia (OZCLIM), and for training in climate change V&A assessment (VANDACLIM)

An analysis of the impact of the Gaia Theory on Ecology and Evolutionary Theory

This paper investigates the impact of ideas published within the Gaia theory (as set out by James Lovelock in 1979), on the study of Ecology and Evolutionary Theory. Developments within both disciplines have been influenced, and shaped by the Gaia theory and the paper discusses these. The development of the Daisyworld model, which highlighted for ecologists the importance of interactions within an ecosystem between the biota and the abiotic world, contributed to the understanding of biodiversity. The Gaia theory also predicted the causal link between increased biodiversity and increasing stability of populations. The Gaian influence on the development of Evolutionary theory can be found in the idea that life on earth works with the abiotic environment as a self-regulatory system. This idea became the foundation of Earth System Science. These developments have had a wider significance to the study and understanding of science in general. The theory has demonstrated the need for a new way of looking at the development and sustainability of life on earth

Two Spurious Counterexamples To the Principle of Phonology-Free Syntax

The System Development Foundation

Adjacent Graph Based Vulnerability Assessment for Electrical Networks Considering Fault Adjacent Relationships Among Branches

Security issues related to vulnerability assessment in electrical networks are necessary for operators to identify the critical branches. At present, using complex network theory to assess the structural vulnerability of the electrical network is a popular method. However, the complex network theory cannot be comprehensively applicable to the operational vulnerability assessment of the electrical network because the network operation is closely dependent on the physical rules not only on the topological structure. To overcome the problem, an adjacent graph (AG) considering the topological, physical, and operational features of the electrical network is constructed to replace the original network. Through the AG, a branch importance index that considers both the importance of a branch and the fault adjacent relationships among branches is constructed to evaluate the electrical network vulnerability. The IEEE 118-bus system and the French grid are employed to validate the effectiveness of the proposed method.National Natural Science Foundation of China under Grant U1734202National Key Research and Development Plan of China under Grant 2017YFB1200802-12National Natural Science Foundation of China under Grant 51877181National Natural Science Foundation of China under Grant 61703345Chinese Academy of Sciences, under Grant 2018-2019-0