51 research outputs found

    Synthesis and analysis of nonlinear, analog, ultra low power, Bernoulli cell based CytoMimetic circuits for biocomputation

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    A novel class of analog BioElectronics is introduced for the systematic implementation of ultra-low power microelectronic circuits, able to compute nonlinear biological dynamics. This class of circuits is termed ``CytoMimetic Circuits'', in an attempt to highlight their actual function, which is mimicking biological responses, as observed experimentally. Inspired by the ingenious Bernoulli Cell Formalism (BCF), which was originally formulated for the modular synthesis and analysis of linear, time-invariant, high-dynamic range, logarithmic filters, a new, modified mathematical framework has been conceived, termed Nonlinear Bernoulli Cell Formalism (NBCF), which forms the core mathematical framework, characterising the operation of CytoMimetic circuits. The proposed nonlinear, transistor-level mathematical formulation exploits the striking similarities existing between the NBCF and coupled ordinary differential equations, typically appearing in models of naturally encountered biochemical systems. The resulting continuous-time, continuous-value, low-power CytoMimetic electronic circuits succeed in simulating with good accuracy cellular and molecular dynamics and found to be in very good agreement with their biological counterparts. They usually occupy an area of a fraction of a square millimetre, while consuming between hundreds of nanowatts and few tenths of microwatts of power. The systematic nature of the NBCF led to the transformation of a wide variety of biochemical reactions into nonlinear Log-domain circuits, which span a large area of different biological model types. Moreover, a detailed analysis of the robustness and performance of the proposed circuit class is also included in this thesis. The robustness examination has been conducted via post-layout simulations of an indicative CytoMimetic circuit and also by providing fabrication-related variability simulations, obtained by means of analog Monte Carlo statistical analysis for each one of the proposed circuit topologies. Furthermore, a detailed mathematical analysis that is carefully addressing the effect of process-parameters and MOSFET geometric properties upon subthreshold translinear circuits has been conducted for the fundamental translinear blocks, CytoMimetic topologies are comprised of. Finally, an interesting sub-category of Neuromorphic circuits, the ``Log-Domain Silicon Synapses'' is presented and representative circuits are thoroughly analysed by a novel, generalised BC operator framework. This leads to the conclusion that the BC operator consists the heart of such Log-domain circuits, therefore, allows the establishment of a general class of BC-based silicon synaptic circuits, which includes most of the synaptic circuits, implemented so far in Log-domain.Open Acces

    NASA Tech Briefs, February 1991

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    Topics: New Product Ideas; NASA TU Services; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery; Fabrication Technology; Mathematics and Information Sciences; Life Sciences

    18th IEEE Workshop on Nonlinear Dynamics of Electronic Systems: Proceedings

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    Proceedings of the 18th IEEE Workshop on Nonlinear Dynamics of Electronic Systems, which took place in Dresden, Germany, 26 – 28 May 2010.:Welcome Address ........................ Page I Table of Contents ........................ Page III Symposium Committees .............. Page IV Special Thanks ............................. Page V Conference program (incl. page numbers of papers) ................... Page VI Conference papers Invited talks ................................ Page 1 Regular Papers ........................... Page 14 Wednesday, May 26th, 2010 ......... Page 15 Thursday, May 27th, 2010 .......... Page 110 Friday, May 28th, 2010 ............... Page 210 Author index ............................... Page XII

    NASA Thesaurus. Volume 2: Access vocabulary

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    The NASA Thesaurus -- Volume 2, Access Vocabulary -- contains an alphabetical listing of all Thesaurus terms (postable and nonpostable) and permutations of all multiword and pseudo-multiword terms. Also included are Other Words (non-Thesaurus terms) consisting of abbreviations, chemical symbols, etc. The permutations and Other Words provide 'access' to the appropriate postable entries in the Thesaurus

    NASA Tech Briefs, February 1993

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    Topics include: Communication Technology; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery; Fabrication Technology; Mathematics and Information Sciences; Life Sciences

    Oscillatory architecture of memory circuits

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    The coordinated activity between remote brain regions underlies cognition and memory function. Although neuronal oscillations have been proposed as a mechanistic substrate for the coordination of information transfer and memory consolidation during sleep, little is known about the mechanisms that support the widespread synchronization of brain regions and the relationship of neuronal dynamics with other bodily rhythms, such as breathing. During exploratory behavior, the hippocampus and the prefrontal cortex are organized by theta oscillations, known to support memory encoding and retrieval, while during sleep the same structures are dominated by slow oscillations that are believed to underlie the consolidation of recent experiences. The expression of conditioned fear and extinction memories relies on the coordinated activity between the mPFC and the basolateral amygdala (BLA), a neuronal structure encoding associative fear memories. However, to date, the mechanisms allowing this long-range network synchronization of neuronal activity between the mPFC and BLA during fear behavior remain virtually unknown. Using a combination of extracellular recordings and open- and closed-loop optogenetic manipulations, we investigated the oscillatory and coding mechanisms mediating the organization and coupling of the limbic circuit in the awake and asleep brain, as well as during memory encoding and retrieval. We found that freezing, a behavioral expression of fear, is tightly associated with an internally generated brain state that manifests in sustained 4Hz oscillatory dynamics in prefrontal-amygdala circuits. 4Hz oscillations accurately predict the onset and termination of the freezing state. These oscillations synchronize prefrontal-amygdala circuits and entrain neuronal activity to dynamically regulate the development of neuronal ensembles. This enables the precise timing of information transfer between the two structures and the expression of fear responses. Optogenetic induction of prefrontal 4Hz oscillations promotes freezing behavior and the formation of long-lasting fear memory, while closed-loop phase specific manipulations bidirectionally modulate fear expression. Our results unravel a physiological signature of fear memory and identify a novel internally generated brain state, characterized by 4Hz oscillations. This oscillation enables the temporal coordination and information transfer in the prefrontal-amygdala circuit via a phase-specific coding mechanism, facilitating the encoding and expression of fear memory. In the search for the origin of this oscillation, we focused our attention on breathing, the most fundamental and ubiquitous rhythmic activity in life. Using large-scale extracellular recordings from a number of structures, including the medial prefrontal cortex, hippocampus, thalamus, amygdala and nucleus accumbens in mice we identified and characterized the entrainment by breathing of a host of network dynamics across the limbic circuit. We established that fear-related 4Hz oscillations are a state-specific manifestation of this cortical entrainment by the respiratory rhythm. We characterized the translaminar and transregional profile of this entrainment and demonstrated a causal role of breathing in synchronizing neuronal activity and network dynamics between these structures in a variety of behavioral scenarios in the awake and sleep state. We further revealed a dual mechanism of respiratory entrainment, in the form of an intracerebral corollary discharge that acts jointly with an olfactory reafference to coordinate limbic network dynamics, such as hippocampal ripples and cortical UP and DOWN states, involved in memory consolidation. Respiration provides a perennial stream of rhythmic input to the brain. In addition to its role as the condicio sine qua non for life, here we provide evidence that breathing rhythm acts as a global pacemaker for the brain, providing a reference signal that enables the integration of exteroceptive and interoceptive inputs with the internally generated dynamics of the hippocampus and the neocortex. Our results highlight breathing, a perennial rhythmic input to the brain, as an oscillatory scaffold for the functional coordination of the limbic circuit, enabling the segregation and integration of information flow across neuronal networks

    Fourth SIAM Conference on Applications of Dynamical Systems

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    NASA Thesaurus. Volume 1: Hierarchical listing

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    There are 16,713 postable terms and 3,716 nonpostable terms approved for use in the NASA scientific and technical information system in the Hierarchical Listing of the NASA Thesaurus. The generic structure is presented for many terms. The broader term and narrower term relationships are shown in an indented fashion that illustrates the generic structure better than the more widely used BT and NT listings. Related terms are generously applied, thus enhancing the usefulness of the Hierarchical Listing. Greater access to the Hierarchical Listing may be achieved with the collateral use of Volume 2 - Access Vocabulary
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