575 research outputs found

    A STUDY ON DYNAMIC SYSTEMS RESPONSE OF THE PERFORMANCE CHARACTERISTICS OF SOME MAJOR BIOPHYSICAL SYSTEMS

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    Dynamic responses of biophysical systems - performance characteristic

    Application of lean scheduling and production control in non-repetitive manufacturing systems using intelligent agent decision support

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    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Lean Manufacturing (LM) is widely accepted as a world-class manufacturing paradigm, its currency and superiority are manifested in numerous recent success stories. Most lean tools including Just-in-Time (JIT) were designed for repetitive serial production systems. This resulted in a substantial stream of research which dismissed a priori the suitability of LM for non-repetitive non-serial job-shops. The extension of LM into non-repetitive production systems is opposed on the basis of the sheer complexity of applying JIT pull production control in non-repetitive systems fabricating a high variety of products. However, the application of LM in job-shops is not unexplored. Studies proposing the extension of leanness into non-repetitive production systems have promoted the modification of pull control mechanisms or reconfiguration of job-shops into cellular manufacturing systems. This thesis sought to address the shortcomings of the aforementioned approaches. The contribution of this thesis to knowledge in the field of production and operations management is threefold: Firstly, a Multi-Agent System (MAS) is designed to directly apply pull production control to a good approximation of a real-life job-shop. The scale and complexity of the developed MAS prove that the application of pull production control in non-repetitive manufacturing systems is challenging, perplex and laborious. Secondly, the thesis examines three pull production control mechanisms namely, Kanban, Base Stock and Constant Work-in-Process (CONWIP) which it enhances so as to prevent system deadlocks, an issue largely unaddressed in the relevant literature. Having successfully tested the transferability of pull production control to non-repetitive manufacturing, the third contribution of this thesis is that it uses experimental and empirical data to examine the impact of pull production control on job-shop performance. The thesis identifies issues resulting from the application of pull control in job-shops which have implications for industry practice and concludes by outlining further research that can be undertaken in this direction

    Exploring visual representation of sound in computer music software through programming and composition

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    Presented through contextualisation of the portfolio works are developments of a practice in which the acts of programming and composition are intrinsically connected. This practice-based research (conducted 2009–2013) explores visual representation of sound in computer music software. Towards greater understanding of composing with the software medium, initial questions are taken as stimulus to explore the subject through artistic practice and critical thinking. The project begins by asking: How might the ways in which sound is visually represented influence the choices that are made while those representations are being manipulated and organised as music? Which aspects of sound are represented visually, and how are those aspects shown? Recognising sound as a psychophysical phenomenon, the physical and psychological aspects of aesthetic interest to my work are identified. Technological factors of mediating these aspects for the interactive visual-domain of software are considered, and a techno-aesthetic understanding developed. Through compositional studies of different approaches to the problem of looking at sound in software, on screen, a number of conceptual themes emerge in this work: the idea of software as substance, both as a malleable material (such as in live coding), and in terms of outcome artefacts; the direct mapping between audio data and screen pixels; the use of colour that maintains awareness of its discrete (as opposed to continuous) basis; the need for integrated display of parameter controls with their target data; and the tildegraph concept that began as a conceptual model of a gramophone and which is a spatio-visual sound synthesis technique related to wave terrain synthesis. The spiroid-frequency-space representation is introduced, contextualised, and combined both with those themes and a bespoke geometrical drawing system (named thisis), to create a new modular computer music software environment named sdfsys

    Full Issue: Volume 6, Number 1

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    Project OASIS: The Design of a Signal Detector for the Search for Extraterrestrial Intelligence

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    An 8 million channel spectrum analyzer (MCSA) was designed the meet to meet the needs of a SETI program. The MCSA puts out a very large data base at very high rates. The development of a device which follows the MCSA, is presented

    The 1990 Goddard Conference on Space Applications of Artificial Intelligence

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    The papers presented at the 1990 Goddard Conference on Space Applications of Artificial Intelligence are given. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed. The proceedings fall into the following areas: Planning and Scheduling, Fault Monitoring/Diagnosis, Image Processing and Machine Vision, Robotics/Intelligent Control, Development Methodologies, Information Management, and Knowledge Acquisition

    Interpretation of Mutations, Expression, Copy Number in Somatic Breast Cancer: Implications for Metastasis and Chemotherapy

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    Breast cancer (BC) patient management has been transformed over the last two decades due to the development and application of genome-wide technologies. The vast amounts of data generated by these assays, however, create new challenges for accurate and comprehensive analysis and interpretation. This thesis describes novel methods for fluorescence in-situ hybridization (FISH), array comparative genomic hybridization (aCGH), and next generation DNA- and RNA-sequencing, to improve upon current approaches used for these technologies. An ab initio algorithm was implemented to identify genomic intervals of single copy and highly divergent repetitive sequences that were applied to FISH and aCGH probe design. FISH probes with higher resolution than commercially available reagents were developed and validated on metaphase chromosomes. An aCGH microarray was developed that had improved reproducibility compared to the standard Agilent 44K array, which was achieved by placing oligonucleotide probes distant from conserved repetitive sequences. Splicing mutations are currently underrepresented in genome-wide sequencing analyses, and there are limited methods to validate genome-wide mutation predictions. This thesis describes Veridical, a program developed to statistically validate aberrant splicing caused by a predicted mutation. Splicing mutation analysis was performed on a large subset of BC patients previously analyzed by the Cancer Genome Atlas. This analysis revealed an elevated number of splicing mutations in genes involved in NCAM pathways in basal-like and HER2-enriched lymph node positive tumours. Genome-wide technologies were leveraged further to develop chemosensitivity models that predict BC response to paclitaxel and gemcitabine. A type of machine learning, called support vector machines (SVM), was used to create predictive models from small sets of biologically-relevant genes to drug disposition or resistance. SVM models generated were able to predict sensitivity in two groups of independent patient data. High variability between individuals requires more accurate and higher resolution genomic data. However the data themselves are insufficient; also needed are more insightful analytical methods to fully exploit these data. This dissertation presents both improvements in data quality and accuracy as well as analytical procedures, with the aim of detecting and interpreting critical genomic abnormalities that are hallmarks of BC subtypes, metastasis and therapy response

    An investigation of the neural mechanisms of interval timing behaviour

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    Timing behaviour plays an important role in the daily living of individuals from a great variety of species. For example, organisms must be able to discriminate between the durations of relevant events (temporal discrimination) and to regulate their own behaviour in time (temporal differentiation). The processes that allow animals to adjust their behaviour to the temporal regularities of the environment have been studied using different procedures which model the relationship between time and behaviour. A taxonomy of timing based on the subject’s location in time with respect to the signalled duration has been proposed. When an organism judges the duration of an elapsed interval the timing is retrospective (e.g. interval bisection); when it responds during an elapsing duration the timing is immediate (e.g. fixed-interval peak procedure); and finally when it chooses between future delayed outcomes the timing is prospective (e.g. inter-temporal choice schedules). It has been proposed that the cortico-striato-thalamo-cortical (CSTC) circuits play a special role in interval timing and inter-temporal choice behaviour. This thesis examined whether performance of timing tasks by rats induces neuronal activation within the prefrontal cortex and corpus striatum, as revealed by Fos expression, and explored a new approach to analyzing performance in an inter-temporal choice schedule. Chapter 1 describes the literature which forms the background of the project. It reviews interval timing and inter-temporal choice methodology and theory, the neurobiological substrates underlying both kinds of behaviour, and finally Fos expression, as a marker of neuronal activation. Chapters 2-4 present experiments that examined whether, in intact rats, performance of different interval timing tasks was associated with neuronal activation in the dorsal striatum and prefrontal cortex, as revealed by expression of the Fos protein, the product of the immediate-early gene c-fos (Experiments 1-3). Chapters 5-7 present experiments focused on some behavioural and neurobiological aspects of inter-temporal choice behaviour. One purpose of these experiments was to develop an abbreviated approach to estimate the rate of delay discounting (K) and reinforcer size sensitivity parameter (Q) based on the Multiplicative Hyperbolic Model of inter-temporal choice (MHM), using the adjusting-delay schedule. Additionally a novel way of quantifying transitional behaviour in the adjusting-delay schedule was presented based on analysis of the power spectrum of cyclical changes in the adjusting delay, dB (Experiment 4). This approach was used to analyze data obtained from rats performing on the adjusting-delay schedule under methodological manipulations (Experiment 5) and neurobiological interventions (Experiment 6). Experiment 1 (Chapter 2) investigated whether, in intact rats, performance on the discrete-trials temporal discrimination task was associated with neuronal activation in the prefrontal cortex and corpus striatum, as revealed by enhanced Fos expression in these areas. Performance on temporal and light-intensity discrimination tasks was well described by a two-parameter logistic equation. The rats trained under the timing task showed increased Fos expression in the orbital prefrontal cortex (OPFC) and the nucleus accumbens (Acb) compared to the rats trained under the light-intensity discrimination task, indicating a substantial activation of these areas during the timing task. However, there was no evidence for involvement of the dorsal striatum in the performance of this task. Experiment 2 (Chapter 3) examined whether performance on an interval-bisection task in the range of milliseconds showed increased Fos expression in the prefrontal cortex and corpus striatum compared to performance under a light-intensity bisection task. Performance on both bisection tasks conformed to the conventional logistic psychometric function. The rats trained under the timing task showed increased Fos expression in the OPFC, infralimbic and prelimbic cortex and Acb compared to the rats trained under the light-intensity bisection task. The results provided no evidence for an involvement of the dorsal striatum in the performance of this task. Experiment 3 (Chapter 4) investigated whether performance on the fixed-interval peak procedure (FIPP) was associated with increased neuronal activity in the prefrontal cortex and corpus striatum, as revealed by Fos expression. The results showed that response rate during peak trials was characterized by a ‘Gaussian plus ramp’ function, with maximal responding (peak rate) occurring around the time of the reinforcement in the FI trials (peak time). Consistent with the results of Experiments 1 and 2, the concentration of Fos-positive neurones in the OPFC was greater in rats exposed to FIPP than in rats exposed to a VI schedule. However, the results did not provide any evidence for a specific involvement of the dorsal or ventral striatum in FIPP performance. In Experiment 4 (Chapter 5), rats made repeated choices on an adjusting-delay schedule. Indifference delays, calculated from adjusting delays in the last 10 sessions, were shorter when the sizes of reinforcers were 14 and 25 µl of a 0.6 M sucrose solution than when they were 25 and 100 µl of the same solution. The ratio of the indifference delays (d50) was significantly smaller than that predicted on the basis of an assumed linear relation between reinforcer size and instantaneous reinforcer value. Estimates of K and Q fell within the values reported previously. Adjusting delays in successive blocks of trials were analysed using the Fourier transform. The power spectra obtained from individual rats had a dominant frequency that corresponded to a period of oscillation of the adjusting delay between 30 and 100 trial blocks. Power in the dominant frequency band declined with extended training. Experiment 5 (Chapter 6) examined the pattern of oscillation of dB in an adjusting-delay schedule using the power spectrum analysis. The step-size in which the delay to the larger reinforcer (dB) increased or decreased was tested across two conditions. In Condition 1, dB increased or decreased (according to the rats’ choice) by 20% from block n to block n+1. In Condition 2, the step size was 10%. The power spectrum analysis showed that the period of oscillation of the dominant frequency of the spectrum was significantly longer under Condition 2 than under Condition 1. There was a consistent trend for the power of oscillation to be higher in the initial segment of the experiment in both conditions. Experiment 6 (Chapter 7) examined the effect of excitotoxic lesion of the core of the nucleus accumbens (AcbC) on K and Q in an adjusting delay schedule using the same protocol as Experiment 4. The effect of the lesion on the power spectrum parameters was also examined. The AcbC-lesioned group showed significantly lower values of d50 than the sham-lesioned group. The ratio of the indifference delays seen in both groups was substantially less than the value predicted on the basis of an assumed linear relation between reinforcer size and instantaneous reinforcer value. K was higher in the lesioned group than in the sham-lesioned group; Q was not affected by the AcbC lesion. Neither the spectral power within the dominant frequency band nor the period corresponding to the dominant frequency differed significantly between groups. The final chapter (Chapter 8) summarizes the findings of the experiments, and discusses their implications for the putative role of the prefrontal cortex, and ventral and dorsal striatum in interval timing and inter-temporal choice, and for theoretical models of these behaviours. The role of the dorsal striatum is questioned, while a possible role of the Acb in temporal processing is proposed. It is argued that an integrated model of interval timing and inter-temporal choice behaviour may require more than the processes of reinforcement and timing to account for both types of behaviour. Some possible directions for future research in this area are also discussed

    Aeronautical Engineering: A continuing bibliography, supplement 120

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    This bibliography contains abstracts for 297 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1980
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