82 research outputs found

    Abstracts of manuscripts submitted in 1991 for publication

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    This volume contains the abstracts of manuscripts submitted for publication during calendar year 1991 by the staff and students of the Woods Hole Oceanographic Institution. We identify the journal of those manuscripts which are in press or have been published. The volume is intended to be informative, but not a bibliography. The abstracts are listed by title in the Table of Contents and are grouped into one of our five departents, Marine Policy Center, Coastal Research Center, or the student category. An author index is presented in the back to facilitate locating specific papers

    The Second Conference on Lunar Bases and Space Activities of the 21st Century, volume 1

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    These papers comprise a peer-review selection of presentations by authors from NASA, LPI industry, and academia at the Second Conference (April 1988) on Lunar Bases and Space Activities of the 21st Century, sponsored by the NASA Office of Exploration and the Lunar Planetary Institute. These papers go into more technical depth than did those published from the first NASA-sponsored symposium on the topic, held in 1984. Session topics covered by this volume include (1) design and operation of transportation systems to, in orbit around, and on the Moon, (2) lunar base site selection, (3) design, architecture, construction, and operation of lunar bases and human habitats, and (4) lunar-based scientific research and experimentation in astronomy, exobiology, and lunar geology

    Abstracts of manuscripts submitted in 1988 for publication

    Get PDF
    This volume contains the abstracts of manuscripts submitted for publication during calendar year 1988 by the staff and students of the Woods Hole Oceanographic Institution. We identify the journal for those manuscripts which are in press or have been published. The volume is intended to be informative, but not a bibliography. The abstracts are listed by title in the Table of Contents and are grouped into one of our five departments , marine policy, or the student category. An author index is presented in the back to facilitate locating specific papers

    Technology 2002: the Third National Technology Transfer Conference and Exposition, Volume 1

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    The proceedings from the conference are presented. The topics covered include the following: computer technology, advanced manufacturing, materials science, biotechnology, and electronics

    Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

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    Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin

    Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects

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    Regular Abstracts - Tuesday Poster Presentations: no. 1925Metaphase describes a phase of mitosis where chromosomes are attached and oriented on the bipolar spindle for subsequent segregation at anaphase. In diverse cell types, the metaphase spindle is maintained at a relatively constant length. Metaphase spindle length is proposed to be regulated by a balance of pushing and pulling forces generated by distinct sets of spindle microtubules and their interactions with motors and microtubule-associated proteins (MAPs). Spindle length appears important for chromosome segregation fidelity, as cells with shorter or longer than normal metaphase spindles, generated through deletion or inhibition of individual mitotic motors or MAPs, showed chromosome segregation defects. To test the force balance model of spindle length control and its effect on chromosome segregation, we applied fast microfluidic temperature-control with live-cell imaging to monitor the effect of switching off different combinations of antagonistic forces in the fission yeast metaphase spindle. We show that spindle midzone proteins kinesin-5 cut7p and microtubule bundler ase1p contribute to outward pushing forces, and spindle kinetochore proteins kinesin-8 klp5/6p and dam1p contribute to inward pulling forces. Removing these proteins individually led to aberrant metaphase spindle length and chromosome segregation defects. Removing these proteins in antagonistic combination rescued the defective spindle length and, in some combinations, also partially rescued chromosome segregation defects. Our results stress the importance of proper chromosome-to-microtubule attachment over spindle length regulation for proper chromosome segregation.postprin

    Environmental impact statement for the Kennedy Space Center, 1978 - 1979 revision

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    The ongoing operation of KSC for expendable launch vehicles and automated spacecraft, continued development of facility capabilities, and the approved follow-on operations of the Space Transportation System and associated payloads are described. Emphasis is placed on the expendable launch vehicle and space shuttle traffic projected as of January, 1979. The maximum potential effect on the environment is addressed. Site specific environmental effects are summarized. It is indicated that all potential impacts will be localized, of short duration, controllable, and of minimum severity. The impact on land use, air and water quality, weather, and noise effects is covered
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