Deep learning cardiac motion analysis for human survival prediction

Motion analysis is used in computer vision to understand the behaviour of moving objects in sequences of images. Optimising the interpretation of dynamic biological systems requires accurate and precise motion tracking as well as efficient representations of high-dimensional motion trajectories so that these can be used for prediction tasks. Here we use image sequences of the heart, acquired using cardiac magnetic resonance imaging, to create time-resolved three-dimensional segmentations using a fully convolutional network trained on anatomical shape priors. This dense motion model formed the input to a supervised denoising autoencoder (4Dsurvival), which is a hybrid network consisting of an autoencoder that learns a task-specific latent code representation trained on observed outcome data, yielding a latent representation optimised for survival prediction. To handle right-censored survival outcomes, our network used a Cox partial likelihood loss function. In a study of 302 patients the predictive accuracy (quantified by Harrell's C-index) was significantly higher (p < .0001) for our model C=0.73 (95$\%$ CI: 0.68 - 0.78) than the human benchmark of C=0.59 (95$\%$ CI: 0.53 - 0.65). This work demonstrates how a complex computer vision task using high-dimensional medical image data can efficiently predict human survival

Multiple 2D self organising map network for surface reconstruction of 3D unstructured data

Surface reconstruction is a challenging task in reverse engineering because it must represent the surface which is similar to the original object based on the data obtained. The data obtained are mostly in unstructured type whereby there is not enough information and incorrect surface will be obtained. Therefore, the data should be reorganised by finding the correct topology with minimum surface error. Previous studies showed that Self Organising Map (SOM) model, the conventional surface approximation approach with Non Uniform Rational B-Splines (NURBS) surfaces, and optimisation methods such as Genetic Algorithm (GA), Differential Evolution (DE) and Particle Swarm Optimisation (PSO) methods are widely implemented in solving the surface reconstruction. However, the model, approach and optimisation methods are still suffer from the unstructured data and accuracy problems. Therefore, the aims of this research are to propose Cube SOM (CSOM) model with multiple 2D SOM network in organising the unstructured surface data, and to propose optimised surface approximation approach in generating the NURBS surfaces. GA, DE and PSO methods are implemented to minimise the surface error by adjusting the NURBS control points. In order to test and validate the proposed model and approach, four primitive objects data and one medical image data are used. As to evaluate the performance of the proposed model and approach, three performance measurements have been used: Average Quantisation Error (AQE) and Number Of Vertices (NOV) for the CSOM model while surface error for the proposed optimised surface approximation approach. The accuracy of AQE for CSOM model has been improved to 64% and 66% when compared to 2D and 3D SOM respectively. The NOV for CSOM model has been reduced from 8000 to 2168 as compared to 3D SOM. The accuracy of surface error for the optimised surface approximation approach has been improved to 7% compared to the conventional approach. The proposed CSOM model and optimised surface approximation approach have successfully reconstructed surface of all five data with better performance based on three performance measurements used in the evaluation

Weighted ensemble of deep learning models based on comprehensive learning particle swarm optimization for medical image segmentation.

In recent years, deep learning has rapidly become a method of choice for segmentation of medical images. Deep neural architectures such as UNet and FPN have achieved high performances on many medical datasets. However, medical image analysis algorithms are required to be reliable, robust, and accurate for clinical applications which can be difficult to achieve for some single deep learning methods. In this study, we introduce an ensemble of classifiers for semantic segmentation of medical images. The ensemble of classifiers here is a set of various deep learning-based classifiers, aiming to achieve better performance than using a single classifier. We propose a weighted ensemble method in which the weighted sum of segmentation outputs by classifiers is used to choose the final segmentation decision. We use a swarm intelligence algorithm namely Comprehensive Learning Particle Swarm Optimization to optimize the combining weights. Dice coefficient, a popular performance metric for image segmentation, is used as the fitness criteria. Experiments conducted on some medical datasets of the CAMUS competition on cardiographic image segmentation show that our method achieves better results than both the constituent segmentation models and the reported model of the CAMUS competition