B2B Infrastructures in the Process of Drug Discovery and Healthcare

In this paper we describe a demonstration of an innovative B2B infrastructure which can be used to support collaborations in the pharmaceutical industry to achieve the drug discovery goal. Based on experience gained in a wide range of collaborative projects in the areas of grid technology, semantics and data management we show future work and new topics in B2B infrastructures which arise when considering the use of patient records in the process of drug discovery and in healthcare applications

Autonomic care platform for optimizing query performance

Background: As the amount of information in electronic health care systems increases, data operations get more complicated and time-consuming. Intensive Care platforms require a timely processing of data retrievals to guarantee the continuous display of recent data of patients. Physicians and nurses rely on this data for their decision making. Manual optimization of query executions has become difficult to handle due to the increased amount of queries across multiple sources. Hence, a more automated management is necessary to increase the performance of database queries. The autonomic computing paradigm promises an approach in which the system adapts itself and acts as self-managing entity, thereby limiting human interventions and taking actions. Despite the usage of autonomic control loops in network and software systems, this approach has not been applied so far for health information systems. Methods: We extend the COSARA architecture, an infection surveillance and antibiotic management service platform for the Intensive Care Unit (ICU), with self-managed components to increase the performance of data retrievals. We used real-life ICU COSARA queries to analyse slow performance and measure the impact of optimizations. Each day more than 2 million COSARA queries are executed. Three control loops, which monitor the executions and take action, have been proposed: reactive, deliberative and reflective control loops. We focus on improvements of the execution time of microbiology queries directly related to the visual displays of patients' data on the bedside screens. Results: The results show that autonomic control loops are beneficial for the optimizations in the data executions in the ICU. The application of reactive control loop results in a reduction of 8.61% of the average execution time of microbiology results. The combined application of the reactive and deliberative control loop results in an average query time reduction of 10.92% and the combination of reactive, deliberative and reflective control loops provides a reduction of 13.04%. Conclusions: We found that by controlled reduction of queries' executions the performance for the end-user can be improved. The implementation of autonomic control loops in an existing health platform, COSARA, has a positive effect on the timely data visualization for the physician and nurse

Semantically Resolving Type Mismatches in Scientific Workflows

Scientists are increasingly utilizing Grids to manage large data sets and execute scientific experiments on distributed resources. Scientific workflows are used as means for modeling and enacting scientific experiments. Windows Workflow Foundation (WF) is a major component of Microsoft’s .NET technology which offers lightweight support for long-running workflows. It provides a comfortable graphical and programmatic environment for the development of extended BPEL-style workflows. WF’s visual features ease the syntactic composition of Web services into scientific workflows but do nothing to assure that information passed between services has consistent semantic types or representations or that deviant flows, errors and compensations are handled meaningfully. In this paper we introduce SAWSDL-compliant annotations for WF and use them with a semantic reasoner to guarantee semantic type correctness in scientific workflows. Examples from bioinformatics are presented

Enabling SmartWorkflows over heterogeneous ID-sensing technologies

Sensing technologies in mobile devices play a key role in reducing the gapbetween the physical and the digital world. The use of automatic identification capabilitiescan improve user participation in business processes where physical elements are involved(Smart Workflows). However, identifying all objects in the user surroundings does notautomatically translate into meaningful services to the user. This work introduces Parkour,an architecture that allows the development of services that match the goals of each ofthe participants in a smart workflow. Parkour is based on a pluggable architecture thatcan be extended to provide support for new tasks and technologies. In order to facilitatethe development of these plug-ins, tools that automate the development process are alsoprovided. Several Parkour-based systems have been developed in order to validate theapplicability of the proposal

mPower: A component-based development framework for multi-agent systems to support business processes

One of the obstacles preventing the widespread adoption of multi-agent systems in industry is the difficulty of implementing heterogeneous interactions among participating agents via asynchronous messages. This difficulty arises from the need to understand how to combine elements of various content languages, ontologies, and interaction protocols in order to construct meaningful and appropriate messages. In this paper mPower, a component-based layered framework for easing the development of multi-agent systems, is described, and the facility for customising the components for reuse in similar domains is explained. The framework builds on the JADE-LEAP platform, which provides a homogeneous layer over diverse operating systems and hardware devices, and allows ubiquitous deployment of applications built on multi-agent systems both in wired and wireless environments. The use of the framework to develop mPowermobile , a multi-agent system to support mobile workforces, is reported

Smart objects as building blocks for the internet of things

The combination of the Internet and emerging technologies such as nearfield communications, real-time localization, and embedded sensors lets us transform everyday objects into smart objects that can understand and react to their environment. Such objects are building blocks for the Internet of Things and enable novel computing applications. As a step toward design and architectural principles for smart objects, the authors introduce a hierarchy of architectures with increasing levels of real-world awareness and interactivity. In particular, they describe activity-, policy-, and process-aware smart objects and demonstrate how the respective architectural abstractions support increasingly complex application