1,361 research outputs found

    Undergraduate Catalog of Studies, 2023-2024

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    Neuromodulatory effects on early visual signal processing

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    Understanding how the brain processes information and generates simple to complex behavior constitutes one of the core objectives in systems neuroscience. However, when studying different neural circuits, their dynamics and interactions researchers often assume fixed connectivity, overlooking a crucial factor - the effect of neuromodulators. Neuromodulators can modulate circuit activity depending on several aspects, such as different brain states or sensory contexts. Therefore, considering the modulatory effects of neuromodulators on the functionality of neural circuits is an indispensable step towards a more complete picture of the brain’s ability to process information. Generally, this issue affects all neural systems; hence this thesis tries to address this with an experimental and computational approach to resolve neuromodulatory effects on cell type-level in a well-define system, the mouse retina. In the first study, we established and applied a machine-learning-based classification algorithm to identify individual functional retinal ganglion cell types, which enabled detailed cell type-resolved analyses. We applied the classifier to newly acquired data of light-evoked retinal ganglion cell responses and successfully identified their functional types. Here, the cell type-resolved analysis revealed that a particular principle of efficient coding applies to all types in a similar way. In a second study, we focused on the issue of inter-experimental variability that can occur during the process of pooling datasets. As a result, further downstream analyses may be complicated by the subtle variations between the individual datasets. To tackle this, we proposed a theoretical framework based on an adversarial autoencoder with the objective to remove inter-experimental variability from the pooled dataset, while preserving the underlying biological signal of interest. In the last study of this thesis, we investigated the functional effects of the neuromodulator nitric oxide on the retinal output signal. To this end, we used our previously developed retinal ganglion cell type classifier to unravel type-specific effects and established a paired recording protocol to account for type-specific time-dependent effects. We found that certain retinal ganglion cell types showed adaptational type-specific changes and that nitric oxide had a distinct modulation of a particular group of retinal ganglion cells. In summary, I first present several experimental and computational methods that allow to study functional neuromodulatory effects on the retinal output signal in a cell type-resolved manner and, second, use these tools to demonstrate their feasibility to study the neuromodulator nitric oxide

    Undergraduate Catalog of Studies, 2023-2024

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    Non-Market Food Practices Do Things Markets Cannot: Why Vermonters Produce and Distribute Food That\u27s Not For Sale

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    Researchers tend to portray food self-provisioning in high-income societies as a coping mechanism for the poor or a hobby for the well-off. They describe food charity as a regrettable band-aid. Vegetable gardens and neighborly sharing are considered remnants of precapitalist tradition. These are non-market food practices: producing food that is not for sale and distributing food in ways other than selling it. Recent scholarship challenges those standard understandings by showing (i) that non-market food practices remain prevalent in high-income countries, (ii) that people in diverse social groups engage in these practices, and (iii) that they articulate diverse reasons for doing so. In this dissertation, I investigate the persistent pervasiveness of non-market food practices in Vermont. To go beyond explanations that rely on individual motivation, I examine the roles these practices play in society. First, I investigate the prevalence of non-market food practices. Several surveys with large, representative samples reveal that more than half of Vermont households grow, hunt, fish, or gather some of their own food. Respondents estimate that they acquire 14% of the food they consume through non-market means, on average. For reference, commercial local food makes up about the same portion of total consumption. Then, drawing on the words of 94 non-market food practitioners I interviewed, I demonstrate that these practices serve functions that markets cannot. Interviewees attested that non-market distribution is special because it feeds the hungry, strengthens relationships, builds resilience, puts edible-but-unsellable food to use, and aligns with a desired future in which food is not for sale. Hunters, fishers, foragers, scavengers, and homesteaders said that these activities contribute to their long-run food security as a skills-based safety net. Self-provisioning allows them to eat from the landscape despite disruptions to their ability to access market food such as job loss, supply chain problems, or a global pandemic. Additional evidence from vegetable growers suggests that non-market settings liberate production from financial discipline, making space for work that is meaningful, playful, educational, and therapeutic. Non-market food practices mend holes in the social fabric torn by the commodification of everyday life. Finally, I synthesize scholarly critiques of markets as institutions for organizing the production and distribution of food. Markets send food toward money rather than hunger. Producing for market compels farmers to prioritize financial viability over other values such as stewardship. Historically, people rarely if ever sell each other food until external authorities coerce them to do so through taxation, indebtedness, cutting off access to the means of subsistence, or extinguishing non-market institutions. Today, more humans than ever suffer from chronic undernourishment even as the scale of commercial agriculture pushes environmental pressures past critical thresholds of planetary sustainability. This research substantiates that alternatives to markets exist and have the potential to address their shortcomings

    Law\u27s Legitimacy: Lon Fuller in a Consequentialist Frame

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    This thesis argues that Lon Fuller’s approach to jurisprudence offers more important support to the rule of law than has been generally recognized. It argues further that a consequentialist lens allows clearer views of Fuller’s strengths in this regard, despite Fuller’s own resistance to consequentialism and despite consequentialism’s blindness to some of Fuller’s depth and texture. This thesis supplies a formula, although one intended only as a guide to thinking, not for actual computation, to drive judicial decision-making. The inputs into this formula are six values widely shared in the United States, modified by case-by-case salience. Kantian deontology strongly influences at least one such value. The thesis defends this unusual pluralistic version of consequentialism. It hopes to encourage jurists to find common ground based on those values, values themselves deeply rooted in American culture, and in so doing, may strengthen the legitimacy of American law and legal institutions. It also gleans from Fuller’s work a sense of his likely metaethics, whose modesty offers an illuminating symmetry with his jurisprudence, especially in comparison with the metaethics and jurisprudence of his two principal rivals, H.L.A. Hart and Ronald Dworkin. Finally, it argues that American law would do well to adopt his approach to the interpretation of legal documents

    Fairness-aware Machine Learning in Educational Data Mining

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    Fairness is an essential requirement of every educational system, which is reflected in a variety of educational activities. With the extensive use of Artificial Intelligence (AI) and Machine Learning (ML) techniques in education, researchers and educators can analyze educational (big) data and propose new (technical) methods in order to support teachers, students, or administrators of (online) learning systems in the organization of teaching and learning. Educational data mining (EDM) is the result of the application and development of data mining (DM), and ML techniques to deal with educational problems, such as student performance prediction and student grouping. However, ML-based decisions in education can be based on protected attributes, such as race or gender, leading to discrimination of individual students or subgroups of students. Therefore, ensuring fairness in ML models also contributes to equity in educational systems. On the other hand, bias can also appear in the data obtained from learning environments. Hence, bias-aware exploratory educational data analysis is important to support unbiased decision-making in EDM. In this thesis, we address the aforementioned issues and propose methods that mitigate discriminatory outcomes of ML algorithms in EDM tasks. Specifically, we make the following contributions: We perform bias-aware exploratory analysis of educational datasets using Bayesian networks to identify the relationships among attributes in order to understand bias in the datasets. We focus the exploratory data analysis on features having a direct or indirect relationship with the protected attributes w.r.t. prediction outcomes. We perform a comprehensive evaluation of the sufficiency of various group fairness measures in predictive models for student performance prediction problems. A variety of experiments on various educational datasets with different fairness measures are performed to provide users with a broad view of unfairness from diverse aspects. We deal with the student grouping problem in collaborative learning. We introduce the fair-capacitated clustering problem that takes into account cluster fairness and cluster cardinalities. We propose two approaches, namely hierarchical clustering and partitioning-based clustering, to obtain fair-capacitated clustering. We introduce the multi-fair capacitated (MFC) students-topics grouping problem that satisfies students' preferences while ensuring balanced group cardinalities and maximizing the diversity of members regarding the protected attribute. We propose three approaches: a greedy heuristic approach, a knapsack-based approach using vanilla maximal 0-1 knapsack formulation, and an MFC knapsack approach based on group fairness knapsack formulation. In short, the findings described in this thesis demonstrate the importance of fairness-aware ML in educational settings. We show that bias-aware data analysis, fairness measures, and fairness-aware ML models are essential aspects to ensure fairness in EDM and the educational environment.Ministry of Science and Culture of Lower Saxony/LernMINT/51410078/E

    LIPIcs, Volume 251, ITCS 2023, Complete Volume

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    LIPIcs, Volume 251, ITCS 2023, Complete Volum

    AI: Limits and Prospects of Artificial Intelligence

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    The emergence of artificial intelligence has triggered enthusiasm and promise of boundless opportunities as much as uncertainty about its limits. The contributions to this volume explore the limits of AI, describe the necessary conditions for its functionality, reveal its attendant technical and social problems, and present some existing and potential solutions. At the same time, the contributors highlight the societal and attending economic hopes and fears, utopias and dystopias that are associated with the current and future development of artificial intelligence

    Undergraduate Catalog of Studies, 2022-2023

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