4,115 research outputs found
Sparsity-Based Super Resolution for SEM Images
The scanning electron microscope (SEM) produces an image of a sample by
scanning it with a focused beam of electrons. The electrons interact with the
atoms in the sample, which emit secondary electrons that contain information
about the surface topography and composition. The sample is scanned by the
electron beam point by point, until an image of the surface is formed. Since
its invention in 1942, SEMs have become paramount in the discovery and
understanding of the nanometer world, and today it is extensively used for both
research and in industry. In principle, SEMs can achieve resolution better than
one nanometer. However, for many applications, working at sub-nanometer
resolution implies an exceedingly large number of scanning points. For exactly
this reason, the SEM diagnostics of microelectronic chips is performed either
at high resolution (HR) over a small area or at low resolution (LR) while
capturing a larger portion of the chip. Here, we employ sparse coding and
dictionary learning to algorithmically enhance LR SEM images of microelectronic
chips up to the level of the HR images acquired by slow SEM scans, while
considerably reducing the noise. Our methodology consists of two steps: an
offline stage of learning a joint dictionary from a sequence of LR and HR
images of the same region in the chip, followed by a fast-online
super-resolution step where the resolution of a new LR image is enhanced. We
provide several examples with typical chips used in the microelectronics
industry, as well as a statistical study on arbitrary images with
characteristic structural features. Conceptually, our method works well when
the images have similar characteristics. This work demonstrates that employing
sparsity concepts can greatly improve the performance of SEM, thereby
considerably increasing the scanning throughput without compromising on
analysis quality and resolution.Comment: Final publication available at ACS Nano Letter
Lensless wide-field fluorescent imaging on a chip using compressive decoding of sparse objects.
We demonstrate the use of a compressive sampling algorithm for on-chip fluorescent imaging of sparse objects over an ultra-large field-of-view (>8 cm(2)) without the need for any lenses or mechanical scanning. In this lensfree imaging technique, fluorescent samples placed on a chip are excited through a prism interface, where the pump light is filtered out by total internal reflection after exciting the entire sample volume. The emitted fluorescent light from the specimen is collected through an on-chip fiber-optic faceplate and is delivered to a wide field-of-view opto-electronic sensor array for lensless recording of fluorescent spots corresponding to the samples. A compressive sampling based optimization algorithm is then used to rapidly reconstruct the sparse distribution of fluorescent sources to achieve approximately 10 microm spatial resolution over the entire active region of the sensor-array, i.e., over an imaging field-of-view of >8 cm(2). Such a wide-field lensless fluorescent imaging platform could especially be significant for high-throughput imaging cytometry, rare cell analysis, as well as for micro-array research
Exploiting flow dynamics for super-resolution in contrast-enhanced ultrasound
Ultrasound localization microscopy offers new radiation-free diagnostic tools
for vascular imaging deep within the tissue. Sequential localization of echoes
returned from inert microbubbles with low-concentration within the bloodstream
reveal the vasculature with capillary resolution. Despite its high spatial
resolution, low microbubble concentrations dictate the acquisition of tens of
thousands of images, over the course of several seconds to tens of seconds, to
produce a single super-resolved image. %since each echo is required to be well
separated from adjacent microbubbles. Such long acquisition times and stringent
constraints on microbubble concentration are undesirable in many clinical
scenarios. To address these restrictions, sparsity-based approaches have
recently been developed. These methods reduce the total acquisition time
dramatically, while maintaining good spatial resolution in settings with
considerable microbubble overlap. %Yet, non of the reported methods exploit the
fact that microbubbles actually flow within the bloodstream. % to improve
recovery. Here, we further improve sparsity-based super-resolution ultrasound
imaging by exploiting the inherent flow of microbubbles and utilize their
motion kinematics. While doing so, we also provide quantitative measurements of
microbubble velocities. Our method relies on simultaneous tracking and
super-localization of individual microbubbles in a frame-by-frame manner, and
as such, may be suitable for real-time implementation. We demonstrate the
effectiveness of the proposed approach on both simulations and {\it in-vivo}
contrast enhanced human prostate scans, acquired with a clinically approved
scanner.Comment: 11 pages, 9 figure
Compressive image sensor architecture with on-chip measurement matrix generation
A CMOS image sensor architecture that uses a cellular automaton for the pseudo-random compressive sampling matrix generation is presented. The image sensor employs in-pixel pulse-frequency modulation and column wise pulse counters to produce compressed samples. A common problem of compressive sampling applied to image sensors is that the size of a full-frame compressive strategy is too large to be stored in an on-chip memory. Since this matrix has to be transmitted to or from the reconstruction system its size would also prevent practical applications. A full-frame compressive strategy generated using a 1-D cellular automaton showing a class III behavior neither needs a storage memory nor needs to be continuously transmitted. In-pixel pulse frequency modulation and up-down counters allow the generation of differential compressed samples directly in the digital domain where it is easier to improve the required dynamic range. These solutions combined together improve the accuracy of the compressed samples thus improving the performance of any generic reconstruction algorithm.Ministerio de Economía y Competitividad TEC2015-66878-C3-1-RJunta de Andalucía TIC 2338-2013Office of Naval Research (USA) N00014141035
- …