Computational Methods and Results for Structured Multiscale Models of Tumor Invasion

We present multiscale models of cancer tumor invasion with components at the molecular, cellular, and tissue levels. We provide biological justifications for the model components, present computational results from the model, and discuss the scientific-computing methodology used to solve the model equations. The models and methodology presented in this paper form the basis for developing and treating increasingly complex, mechanistic models of tumor invasion that will be more predictive and less phenomenological. Because many of the features of the cancer models, such as taxis, aging and growth, are seen in other biological systems, the models and methods discussed here also provide a template for handling a broader range of biological problems

On the foundations of cancer modelling: selected topics, speculations, & perspectives

This paper presents a critical review of selected topics related to the modelling of cancer onset, evolution and growth, with the aim of illustrating, to a wide applied mathematical readership, some of the novel mathematical problems in the field. This review attempts to capture, from the appropriate literature, the main issues involved in the modelling of phenomena related to cancer dynamics at all scales which characterise this highly complex system: from the molecular scale up to that of tissue. The last part of the paper discusses the challenge of developing a mathematical biological theory of tumour onset and evolution

Dark Energy: Observational Evidence and Theoretical Models

The book elucidates the current state of the dark energy problem and presents the results of the authors, who work in this area. It describes the observational evidence for the existence of dark energy, the methods and results of constraining of its parameters, modeling of dark energy by scalar fields, the space-times with extra spatial dimensions, especially Kaluza---Klein models, the braneworld models with a single extra dimension as well as the problems of positive definition of gravitational energy in General Relativity, energy conditions and consequences of their violation in the presence of dark energy. This monograph is intended for science professionals, educators and graduate students, specializing in general relativity, cosmology, field theory and particle physics.Comment: Book, 380 p., 88 figs., 7 tables; 1st volume of three-volume book "Dark energy and dark matter in the Universe", ed. V. Shulga, Kyiv, Academperiodyka, 2013; ISBN 978-966-360-239-4, ISBN 978-966-360-240-0 (vol. 1). arXiv admin note: text overlap with arXiv:0706.0033, arXiv:1104.3029 by other author

Self-similarity in the conformal framework of quiescent cosmology and the Weyl curvature hypothesis

A viable alternative to cosmological inflation is provided by the combined theory of quiescent cosmology and the Weyl curvature hypothesis. We augment the conformal framework of this theory by incorporating the spacetime property of self-similarity. A generalisation of the conformal Killing equation is developed as a definition of asymptotic self-similarity for use in the framework; we derive several propositions and theorems that facilitate the application of this definition, and demonstrate asymptotic self-similarity for FLRW and other models. We also detail the conditions under which self-similarity is preserved by conformal transformations, and investigate its relationship to other symmetry properties in the framework

Quasilinear hyperbolic Fuchsian systems and AVTD behavior in T2-symmetric vacuum spacetimes

We set up the singular initial value problem for quasilinear hyperbolic Fuchsian systems of first order and establish an existence and uniqueness theory for this problem with smooth data and smooth coefficients (and with even lower regularity). We apply this theory in order to show the existence of smooth (generally not analytic) T2-symmetric solutions to the vacuum Einstein equations, which exhibit AVTD (asymptotically velocity term dominated) behavior in the neighborhood of their singularities and are polarized or half-polarized.Comment: 78 page