Object orientation without extending Z

The good news of this paper is that without extending Z, we can elegantly specify object-oriented systems, including encapsulation, inheritance and subtype polymorphism (dynamic dispatch). The bad news is that this specification style is rather different to normal Z specifications, more abstract and axiomatic, which means that it is not so well supported by current Z tools such as animators. It also enforces behavioural subtyping, unlike most object-oriented programming languages. This paper explains the proposed style, with examples, and discusses its advantages and disadvantages

A Reasoner for Calendric and Temporal Data

Calendric and temporal data are omnipresent in countless Web and Semantic Web applications and Web services. Calendric and temporal data are probably more than any other data a subject to interpretation, in almost any case depending on some cultural, legal, professional, and/or locational context. On the current Web, calendric and temporal data can hardly be interpreted by computers. This article contributes to the Semantic Web, an endeavor aiming at enhancing the current Web with well-defined meaning and to enable computers to meaningfully process data. The contribution is a reasoner for calendric and temporal data. This reasoner is part of CaTTS, a type language for calendar definitions. The reasoner is based on a "theory reasoning" approach using constraint solving techniques. This reasoner complements general purpose "axiomatic reasoning" approaches for the Semantic Web as widely used with ontology languages like OWL or RDF

A Reasoner for Calendric and Temporal Data

Calendric and temporal data are omnipresent in countless Web and Semantic Web applications and Web services. Calendric and temporal data are probably more than any other data a subject to interpretation, in almost any case depending on some cultural, legal, professional, and/or locational context. On the current Web, calendric and temporal data can hardly be interpreted by computers. This article contributes to the Semantic Web, an endeavor aiming at enhancing the current Web with well-defined meaning and to enable computers to meaningfully process data. The contribution is a reasoner for calendric and temporal data. This reasoner is part of CaTTS, a type language for calendar definitions. The reasoner is based on a \theory reasoning" approach using constraint solving techniques. This reasoner complements general purpose \axiomatic reasoning" approaches for the Semantic Web as widely used with ontology languages like OWL or RDF

A Dual-Engine for Early Analysis of Critical Systems

This paper presents a framework for modeling, simulating, and checking properties of critical systems based on the Alloy language -- a declarative, first-order, relational logic with a built-in transitive closure operator. The paper introduces a new dual-analysis engine that is capable of providing both counterexamples and proofs. Counterexamples are found fully automatically using an SMT solver, which provides a better support for numerical expressions than the existing Alloy Analyzer. Proofs, however, cannot always be found automatically since the Alloy language is undecidable. Our engine offers an economical approach by first trying to prove properties using a fully-automatic, SMT-based analysis, and switches to an interactive theorem prover only if the first attempt fails. This paper also reports on applying our framework to Microsoft's COM standard and the mark-and-sweep garbage collection algorithm.Comment: Workshop on Dependable Software for Critical Infrastructures (DSCI), Berlin 201

The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA

Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells. Here, we identify the host transcript of miR-223, linc-223, as a novel functional long non-coding RNA (lncRNA) in AML. We show that from the primary nuclear transcript, the alternative production of miR-223 and linc-223 is finely regulated during monocytic differentiation. Moreover, linc-223 expression inhibits cell cycle progression and promotes monocytic differentiation of AML cells. We also demonstrate that endogenous linc-223 localizes in the cytoplasm and acts as a competing endogenous RNA for miR-125-5p, an oncogenic microRNA in leukemia. In particular, we show that linc-223 directly binds to miR-125-5p and that its knockdown increases the repressing activity of miR-125-5p resulting in the downregulation of its target interferon regulatory factor 4 (IRF4), which it was previously shown to inhibit the oncogenic activity of miR-125-5p in vivo. Furthermore, data from primary AML samples show significant downregulation of linc-223 in different AML subtypes. Therein, these findings indicate that the newly identified lncRNA linc-223 may have an important role in myeloid differentiation and leukemogenesis, at least in part, by cross-talking with IRF4 mRNA

Object-oriented Programming Laws for Annotated Java Programs

Object-oriented programming laws have been proposed in the context of languages that are not combined with a behavioral interface specification language (BISL). The strong dependence between source-code and interface specifications may cause a number of difficulties when transforming programs. In this paper we introduce a set of programming laws for object-oriented languages like Java combined with the Java Modeling Language (JML). The set of laws deals with object-oriented features taking into account their specifications. Some laws deal only with features of the specification language. These laws constitute a set of small transformations for the development of more elaborate ones like refactorings