From Deux Danses to Fluctuations: Compositional components and innovations in two solo trombone works of Jean-Michel Defaye.

The purpose of this dissertation is to investigate and document the compositional components and innovations in the compositional style of Jean-Michel Defaye as they relate to two of his works for solo trombone, Deux Danses (1953, trombone and piano) and Fluctuations (1980, trombone solo, six trombones and two percussionists.) This document investigates the circumstances surrounding the creation of each piece as well as the compositional processes of Monsieur Defaye. Jean-Michel Defaye is an important composer for his commitment to the quality and challenge of the trombone literature he creates. The importance of Deux Danses is in the fact that it was this piece that put Defaye in the international spotlight. Solo works with chamber ensemble, such as Fluctuations, must be more seriously considered for performance if the standard solo repertoire for trombone is to be further expanded. Jazz style is an integral part of both of these important works and a necessary component to fully realize the composer's intent. Monsieur Defaye has demonstrated a commitment to composing for the instrument over the long term and has a sustained interest in participating in the further development of serious literature for all brass instruments. This study will add to the limited published material on Defaye and is intended to further the cause of research into the works of this important composer

A dramaturgy of intermediality: composing with integrative design

The thesis investigates and develops a compositional system on intermediality in theatre and performance as a dramaturgical practice through integrative design. The position of the visual/sonic media in theatre and performance has been altered by the digitalisation and networking of media technologies, which enables enhanced dynamic variables in the intermedial processes. The emergent intermediality sites are made accessible by developments in media technologies and form part of broader changes towards a mediatised society: a simultaneous shift in cultural contexts, theatre practice and audience perception. The practice-led research is situated within a postdramatic context and develops a system of compositional perspectives and procedures to enhance the knowledge of a dramaturgy on intermediality. The intermediality forms seem to re-situate the actual/virtual relations in theatre and re-construct the processes of theatricalisation in the composition of the stage narrative. The integration of media and performers produces a compositional environment of semiosis, where the theatre becomes a site of narration, and the designed integration in-between medialities emerges as intermediality sites in the performance event. A selection of performances and theatre directors is identified, who each in distinct ways integrate mediating technologies as a core element in their compositional design. These directors and performances constitute a source of reflection on compositional strategies from the perspective of practice, and enable comparative discussions on dramaturgical design and the consistency of intermediality sites. The practice-led research realised a series of prototyping processes situated in performance laboratories in 2004-5. The laboratories staged investigations into the relation between integrative design procedures and parameters for composition of intermediality sites, particularly the relative presence in-between the actual and the virtual, and the relative duration and distance in-between timeness and placeness. The integration of performer activities and media operations into dramaturgical structures were developed as a design process of identifying the mapping and experiencing the landscape through iterative prototyping. The developed compositional concepts and strategies were realised in the prototype performance Still I Know Who I Am, performed October 2006. This final research performance was a full-scale professional production, which explored the developed dramaturgical designs through creative practice. The performance was realised as a public event, and composed of a series of scenes, each presenting a specific composite of the developed integrative design strategies, and generating a particular intermediality site. The research processes in the performance laboratories and the prototype performance developed on characteristics, parameters and procedures of compositional strategies, investigating the viability of a dramaturgy of intermediality through integrative design. The practice undertaken constitutes raw material from which the concepts are drawn and underpins the premises for the theoretical reflections

Ephemeral repetitions; deconstructing vocal technique and freeing spontaneous expression for authentic vocal performance

In this thesis, I argue that somatic methodologies used in actor and dance training can be applied to a classical singer’s process to effectively address the dichotomy of technique to freedom in vocal expression. My research is informed by my multi-disciplined background as a performer and educator and, in drawing on these practices and investigating the liminal spaces between them, I uncover a separation in the pedagogy. In response, I propose approaches which encourage a mobilisation of new multidisciplinary tools that may prove useful in finding a deeper connection in performance. My research integrates the exploration of phenomenological insights as they relate to vocality. Vital in my findings is how deconstructing traditional texts and forms, through autoethnographic performance practices, can successfully serve as a key method for developing deeper somatic reflexivity, accessing the responses of the body and leading to a more expressive, authentic voice. These finding are reflected in my praxis through the music theatre piece, The Crook of Your Arm. Devised through an improvisational process, the autobiographical narrative that surfaced became key in supporting my assertions that examining the connections between the lived body and voice, through the centralisation of self, is critical in the singer’s process

Music in Evolution and Evolution in Music

Music in Evolution and Evolution in Music by Steven Jan is a comprehensive account of the relationships between evolutionary theory and music. Examining the ‘evolutionary algorithm’ that drives biological and musical-cultural evolution, the book provides a distinctive commentary on how musicality and music can shed light on our understanding of Darwin’s famous theory, and vice-versa. Comprised of seven chapters, with several musical examples, figures and definitions of terms, this original and accessible book is a valuable resource for anyone interested in the relationships between music and evolutionary thought. Jan guides the reader through key evolutionary ideas and the development of human musicality, before exploring cultural evolution, evolutionary ideas in musical scholarship, animal vocalisations, music generated through technology, and the nature of consciousness as an evolutionary phenomenon. A unique examination of how evolutionary thought intersects with music, Music in Evolution and Evolution in Music is essential to our understanding of how and why music arose in our species and why it is such a significant presence in our lives

2022-2023 Course Catalog

An annual catalog of courses and course descriptions offered at the University of Montana.https://scholarworks.umt.edu/coursecatalogs_asc/1117/thumbnail.jp

2017-2018 Undergraduate Catalog

Annual publication of degrees offered and their requirements for all undergraduate students enrolled at the University of Central Oklahoma

2018-2019 Undergraduate Catalog

Annual publication of degrees offered and their requirements for all undergraduate students enrolled at the University of Central Oklahoma

The role of ABCB1 and ABCB5 in paediatric inflammatory bowel disease

ABC transporters play an important role in drug disposition. ABCB1, the most studied representative member of this transporter superfamily, can influence drug response and shape multi-drug resistance in cancer and various diseases including inflammatory bowel disease. Adult studies have shown inter-individual variability in expression between patients with inflammatory bowel disease and healthy controls, which can be modified by corticosteroid administration, a common treatment agent for inflammatory bowel disease. ABCB5 is a novel transporter highly homologous to ABCB1. This thesis focusses on an inception pilot cohort of children and young people with newly diagnosed inflammatory bowel disease and healthy controls. The purpose of this thesis is to investigate the expression of ABCB1 and ABCB5 in vitro and ex vivo, to test the hypothesis that both are important in children with inflammatory bowel disease with respect to expression, to investigate how expression varies with genotype, and to explore the possible role of ABCB5 as corticosteroid transporter. De novo production of stable and transient overexpressing mammalian ABCB5 clones confirmed high gene expression at the mRNA level, but no ABCB5 protein isoforms were detectable, despite repeated attempts and investigation of human malignant cell derived ABCB5 expressing clones donated by experts in the field. Radiolabeled drug uptake studies with corticosteroids commonly implemented in the treatment of inflammatory bowel disease, showed that corticosteroid efflux was not mediated by any of the ABCB5 overexpressing mammalian cell lines. Children with newly diagnosed inflammatory bowel disease and healthy controls recruited at a regional tertiary children’s hospital were genotyped for common ABCB1 and novel ABCB5 single nucleotide polymorphisms. The genotype variation observed between cases and controls was not statistically different at the point of diagnosis. The minor allele frequency for rs2032582 (G2677T in exon 21 of the ABCB1 gene) was significantly different between cases and controls (p=0.01), but this did not withstand correction for multiple testing. ABCB1 and ABCB5 gene expression profiling of blood and intestinal biopsies from 16 patients with inflammatory bowel disease and 20 controls was determined. No significant variability was observed in ABCB1 gene expression across ABCB1 genotypes or clinical phenotypes (inflammatory bowel disease versus healthy state). ABCB5 expression was not detectable in blood or intestinal biopsies taken from the small intestine and sigmoid colon of the study participants. ABCB1 and ABCB5 protein expression was characterized by immunohistochemistry in intestinal biopsies from study participants. ABCB1 showed inter and intraindividual variability in expression across blood samples and intestinal biopsies from cases and controls, but this was not significantly different. There was significant correlation between gene expression and protein expression in sigmoid colon (p=0.007). Non-specific background staining for ABCB5 by immunohistochemistry was noted, which did not allow for reliable quantification of ABCB5 protein expression in the small intestine and sigmoid colon. Treatment response to corticosteroids in a subgroup of patients with ulcerative colitis showed weak correlation with ABCB1 expression. In conclusion, in this pilot set of experiments, no difference was identified in ABCB1 and ABCB5 expression at mRNA and protein level in peripheral blood cells, small intestine and colonic biopsies, taken from children with inflammatory bowel disease and healthy controls. The study was limited by the small sample size; further studies will be needed for confirmation of these results. Importantly, there was no ABCB5 expression at the protein level and no functional activity was identifiable with respect to corticosteroid efflux in transfected cell lines. Further work is required to appreciate the role of ABCB5 in intestinal physiology and pathology