Disentangling astroglial physiology with a realistic cell model in silico

Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. Our simulations suggest that currents generated by glutamate transporters or K+ channels have negligible distant effects on membrane voltage and that individual astrocytes can successfully handle extracellular K+ hotspots. We show how intracellular Ca2+ buffers affect Ca2+ waves and why the classical Ca2+ sparks-and-puffs mechanism is theoretically compatible with common readouts of astroglial Ca2+ imaging

Augmenting the field experience: a student-led comparison of techniques and technologies

In this study we report on our experiences of creating and running a student fieldtrip exercise which allowed students to compare a range of approaches to the design of technologies for augmenting landscape scenes. The main study site is around Keswick in the English Lake District, Cumbria, UK, an attractive upland environment popular with tourists and walkers. The aim of the exercise for the students was to assess the effectiveness of various forms of geographic information in augmenting real landscape scenes, as mediated through a range of techniques and technologies. These techniques were: computer-generated acetate overlays showing annotated wireframe views from certain key points; a custom-designed application running on a PDA; a mediascape running on the mScape software on a GPS-enabled mobile phone; Google Earth on a tablet PC; and a head-mounted in-field Virtual Reality system. Each group of students had all five techniques available to them, and were tasked with comparing them in the context of creating a visitor guide to the area centred on the field centre. Here we summarise their findings and reflect upon some of the broader research questions emerging from the project

Introduction to location-based mobile learning

[About the book] The report follows on from a 2-day workshop funded by the STELLAR Network of Excellence as part of their 2009 Alpine Rendez-Vous workshop series and is edited by Elizabeth Brown with a foreword from Mike Sharples. Contributors have provided examples of innovative and exciting research projects and practical applications for mobile learning in a location-sensitive setting, including the sharing of good practice and the key findings that have resulted from this work. There is also a debate about whether location-based and contextual learning results in shallower learning strategies and a section detailing the future challenges for location-based learning

D13.2 Techniques and performance analysis on energy- and bandwidth-efficient communications and networking

Deliverable D13.2 del projecte europeu NEWCOM#The report presents the status of the research work of the various Joint Research Activities (JRA) in WP1.3 and the results that were developed up to the second year of the project. For each activity there is a description, an illustration of the adherence to and relevance with the identified fundamental open issues, a short presentation of the main results, and a roadmap for the future joint research. In the Annex, for each JRA, the main technical details on specific scientific activities are described in detail.Peer ReviewedPostprint (published version

Performance Comparison of Dual Connectivity and Hard Handover for LTE-5G Tight Integration in mmWave Cellular Networks

MmWave communications are expected to play a major role in the Fifth generation of mobile networks. They offer a potential multi-gigabit throughput and an ultra-low radio latency, but at the same time suffer from high isotropic pathloss, and a coverage area much smaller than the one of LTE macrocells. In order to address these issues, highly directional beamforming and a very high-density deployment of mmWave base stations were proposed. This Thesis aims to improve the reliability and performance of the 5G network by studying its tight and seamless integration with the current LTE cellular network. In particular, the LTE base stations can provide a coverage layer for 5G mobile terminals, because they operate on microWave frequencies, which are less sensitive to blockage and have a lower pathloss. This document is a copy of the Master's Thesis carried out by Mr. Michele Polese under the supervision of Dr. Marco Mezzavilla and Prof. Michele Zorzi. It will propose an LTE-5G tight integration architecture, based on mobile terminals' dual connectivity to LTE and 5G radio access networks, and will evaluate which are the new network procedures that will be needed to support it. Moreover, this new architecture will be implemented in the ns-3 simulator, and a thorough simulation campaign will be conducted in order to evaluate its performance, with respect to the baseline of handover between LTE and 5G.Comment: Master's Thesis carried out by Mr. Michele Polese under the supervision of Dr. Marco Mezzavilla and Prof. Michele Zorz

An Evaluation of the Prison Radio Association’s Activity Final Report Year 3: The way forward

The PRA developed a strategic three year activity plan (2007- 2009) which has been evaluated annually by the Hallam Centre for Community Justice at Sheffield Hallam University. In 2009, key PRA objectives were to continue to provide prisons with support to set up their own radio projects, to host the Second Annual Conference and Awards Ceremony, to develop a National Prison Radio Service (NPRS) and to develop a sustainable funding strategy and press strategy. The findings of the evaluation of these three activity areas are contained within the main body of this report

Final report on the evaluation of RRM/CRRM algorithms

Deliverable public del projecte EVERESTThis deliverable provides a definition and a complete evaluation of the RRM/CRRM algorithms selected in D11 and D15, and evolved and refined on an iterative process. The evaluation will be carried out by means of simulations using the simulators provided at D07, and D14.Preprin