In/Visibility in the Internet’s Third Age

Current research (see, for example, Cheong, Martin and Macfadyen, 2012) on patterns of global and intercultural new media penetration and use nevertheless reveal the thinness of earlier utopian hopes for a technologically mediated “global village.” Nevertheless, new media are transforming local, political and cultural landscapes. What has (and who have) been made newly in/visible by new media and technologies? Participants in this panel will present\ud and discuss aspects of their current research that shed light, in different ways, on questions of in/visibility in this, the Internet’s ‘Third Age’ (Wellman, 2011)

Evaluation of Time-Critical Communications for IEC 61850-Substation Network Architecture

Present-day developments, in electrical power transmission and distribution, require considerations of the status quo. In other meaning, international regulations enforce increasing of reliability and reducing of environment impact, correspondingly they motivate developing of dependable systems. Power grids especially intelligent (smart grids) ones become industrial solutions that follow standardized development. The International standardization, in the field of power transmission and distribution, improve technology influences. The rise of dedicated standards for SAS (Substation Automation Systems) communications, such as the leading International Electro-technical Commission standard IEC 61850, enforces modern technological trends in this field. Within this standard, a constraint of low ETE (End-to-End) latency should be respected, and time-critical status transmission must be achieved. This experimental study emphasis on IEC 61850 SAS communication standard, e.g. IEC 61850 GOOSE (Generic Object Oriented Substation Events), to implement an investigational method to determine the protection communication delay. This method observes GOOSE behaviour by adopting monitoring and analysis capabilities. It is observed by using network test equipment, i.e. SPAN (Switch Port Analyser) and TAP (Test Access Point) devices, with on-the-shelf available hardware and software solutions

Communication systems supporting multimedia multi-user applications

Multimedia multi-user applications are becoming more and more important. Intensive research is underway on the design of protocols and protocol entities for future communication systems supporting multimedia multi-user applications. The development of a service description ensures that protocol designs actually produce the required functional behavior. The authors explain the approach to the description of a multimedia multi-user service. An example illustrates the use of the service description in the design of communication systems. Next, they present the basic requirements of multimedia and multi-user communications. A call model underlies and structures the service description. Finally, the authors describe the service in terms of service element

Modified ES / OP9 co-culture protocol provides enhanced characterization of hematopoietic progeny.

The in vitro differentiation of ES cells towards a hematopoietic cell fate is useful when studying cell populations that are difficult to access in vivo and for characterizing the earliest genes involved in hematopoiesis, without having to deal with embryonic lethalities. The ES/OP9 co-culture system was originally designed to produce hematopoietic progeny, without the over production of macrophages, as the OP9 stromal cell line is derived from the calvaria of osteopetrosis mutant mice that lack functional M-CSF. The in vitro ES/OP9 co-culture system can be used in order to recapitulate early hematopoietic development. When cultured on OP9 stromal cells, ES cells differentiate into Flk-1+ hemangioblasts, hematopoietic progenitors, and finally mature, terminally differentiated lineages. The standard ES/OP9 co-culture protocol entails the placement of ES cells onto a confluent layer of OP9 cells; as well as, periodic replating steps in order to remove old, contaminating OP9 cells. Furthermore, current protocols involve evaluating only the hematopoietic cells found in suspension and are not optimized for evaluation of ES-derived progeny at each day of differentiation. However, with replating steps and the harvesting of only suspension cells one potentially misses a large portion of ES-derived progeny and developing hematopoietic cells. This issue becomes important to address when trying to characterize hematopoietic defects associated with knockout ES lines. Here we describe a modified ES/mStrawberry OP9 co-culture, which allows for the elimination of contaminating OP9 cells from downstream assays. This method allows for the complete evaluation of all ES-derived progeny at all days of co-culture, resulting in a hematopoietic differentiation pattern, which more directly corresponds to the hematopoietic differentiation pattern observed within the embryo

Networked Living: a new approach to teaching introductory ICT

The course T175 Networked Living is a 300 hour, multiple media, distance learning course offered by the UK Open University. The first presentation of the course, in 2005, attracted over 1600 students. T175 introduces students to general concepts of information and communication technology in a range of contexts, including: communication and identity; entertainment and information; and health, transport and government. It is an introductory (level 1) course for a variety of bachelors’ degrees, including the BSc programmes in: Information and Communication Technology; IT and Computing; and Technology; as well as the BEng engineering programme. The course was designed with a focus on retention of students and preparing them for further study. Student workload and pacing was carefully planned and there is a significant study skills component. The course uses a range of media, including: text, audio, computer animation and other software, and a website. Active learning is encouraged by means of activities, online quizzes, animations, spreadsheets and a learning journal. Continuous assessment is carried out via a mix of multiple-choice assignments (to test factual and numerical skills) and written assignments (which include elementary research into new topics). The course culminates with a written end-of-course assessment. This includes a major reflective component, as well as more traditional questions designed to test knowledge and understanding

Opportunities for organoids as new models of aging.

The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use. More importantly, they may not reflect directly on the process of aging in people. Human cell culture provides an alternative, but many functional signs of aging occur at the level of tissues rather than cells and are therefore not readily apparent in traditional cell culture models. Organoids have the potential to effectively balance between the strengths and weaknesses of traditional models of aging. They have sufficient complexity to capture relevant signs of aging at the molecular, cellular, and tissue levels, while presenting an experimentally tractable alternative to animal studies. Organoid systems have been developed to model many human tissues and diseases. Here we provide a perspective on the potential for organoids to serve as models for aging and describe how current organoid techniques could be applied to aging research