99 research outputs found

    Value of Mineralogical Monitoring for the Mining and Minerals Industry In memory of Prof. Dr. Herbert Pöllmann

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    This Special Issue, focusing on the value of mineralogical monitoring for the mining and minerals industry, should include detailed investigations and characterizations of minerals and ores of the following fields for ore and process control: Lithium ores—determination of lithium contents by XRD methods; Copper ores and their different mineralogy; Nickel lateritic ores; Iron ores and sinter; Bauxite and bauxite overburden; Heavy mineral sands. The value of quantitative mineralogical analysis, mainly by XRD methods, combined with other techniques for the evaluation of typical metal ores and other important minerals, will be shown and demonstrated for different minerals. The different steps of mineral processing and metal contents bound to different minerals will be included. Additionally, some processing steps, mineral enrichments, and optimization of mineral determinations using XRD will be demonstrated. Statistical methods for the treatment of a large set of XRD patterns of ores and mineral concentrates, as well as their value for the characterization of mineral concentrates and ores, will be demonstrated. Determinations of metal concentrations in minerals by different methods will be included, as well as the direct prediction of process parameters from raw XRD data

    Biological predictors of survival in limphoma and mechanisms underlying follicular lymphoma transformaion into diffuse large B cell lymphoma (vol I e II)

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    RESUMO: Os biomarcadores tumorais permitem identificar os doentes com maior risco de recorrência da doença, predizer a resposta tumoral à terapêutica e, finalmente, definir candidatos a novos alvos terapêuticos. Novos biomarcadores são especialmente necessários na abordagem clínica dos linfomas. Actualmente, esses tumores são diagnosticados através de uma combinação de características morfológicas, fenotípicas e moleculares, mas o prognóstico e o planeamento terapêutico estão quase exclusivamente dependentes de características clínicas. Estes factores clínicos são, na maioria dos linfomas, insuficientes numa proporção significativa dos doentes, em particular, aqueles com pior prognóstico. O linfoma folicular (LF) é, globalmente, o segundo subtipo mais comum de linfoma. É tipicamente uma doença indolente com uma sobrevida média entre os 8 e 12 anos, mas é geralmente fatal quando se transforma num linfoma agressivo de alto grau, habitualmente o linfoma difuso de grandes células B (LDGCB). Morfologicamente e funcionalmente, as células do LF recapitulam as células normais do centro germinativo na sua dependência de sobrevivência do microambiente não-tumoral, especialmente das células do sistema imunológico. Biomarcadores preditivos de transformação não existem pelo que um melhor conhecimento da biologia intrínseca de progressão do LF poderá revelar novos candidatos. Nesta tese descrevo duas abordagens distintas para a descoberta de novos biomarcadores. A primeira, o estudo da expressão global de genes ('genomics') obtidos por técnicas de alto rendimento que analisam todo o genoma humano sequenciado, permitindo identificar novas anomalias genéticas que possam representar mecanismos biológicos importantes de transformação. São descritos novos genes e alterações genómicas associados à transformação do LF, sendo especialmente relevantes as relacionadas com os eventos iniciais de transformação em LDGCB. A segunda, baseou-se em várias hipóteses centradas no microambiente do LF, rico em vários tipos de células nãomalignas. Os estudos imunoarquitectural de macrófagos, células T regulatórias e densidade de microvasos efectuado em biopsias de diagnóstico de doentes com LF tratados uniformemente correlacionaram-se significativamente, e independentemente dos critérios clínicos, com a evolução clínica e, mais importante, com o risco de transformação em LDGCB. Nesta tese, foram preferencialmente utilizadas (e optimizadas) técnicas que permitam o uso de amostras fixadas em parafina e formalina (FFPET). Estas são facilmente acessíveis a partir das biopsias de diagnóstico de rotina presentes nos arquivos de todos os departamentos de patologia, facilitando uma transição rápida dos novos marcadores para a prática clínica. Embora o FL fosse o tema principal da tese, os novos achados permitiram estender facilmente hipóteses semelhantes a outros subtipos de linfoma. Assim, são propostos e validados vários biomarcadores promissores e relacionados com o microambiente não tumoral, sobretudo dependentes das células do sistema imunológico, como contribuintes importantes para a biologia dos linfomas. Estes sugerem novas opções para a abordagem clínica destas doenças e, eventualmente, novos alvos terapêuticos.------------- ABSTRACT: Cancer biomarkers provide an opportunity to identify those patients most at risk for disease recurrence, predict which tumours will respond to different therapeutic approaches and ultimately define candidate biomarkers that may serve as targets for personalized therapy. New biomarkers are especially needed in the management of lymphoid cancers. At present, these tumours are diagnosed using a combination of morphologic, phenotypic and molecular features but prognosis and overall survival are mostly dependent on clinical characteristics. In most lymphoma types, these imprecisely assess a significant proportion of patients, in particular, those with very poor outcomes. Follicular lymphoma (FL) is the second most common lymphoma subtype worldwide. It is typically an indolent disease with current median survivals in the range of 8-12 years, but is usually fatal when it transforms into an aggressive high-grade lymphoma, characteristically Diffuse Large B Cell Lymphoma (DLBCL). Morphologically and functionally it recapitulates the normal cells of the germinal center with its survival dependency on non-malignant immune and immunerelated cells. Informative markers of transformation related to the intrinsic biology of FL progression are needed. Within this thesis two separate approaches to biomarker discovery were employed. The first was to study the global expression of genes (‘genomics’) obtained using high-throughput, wholegenome-wide approaches that offered the possibility for discovery of new genetic abnormalities that might represent the important biological mechanisms of transformation. Gene signatures associated with early events of transformation were found. Another approach relied on hypothesis-driven concepts focusing upon the microenvironment, rich in several non-malignant cell types. The immunoarchitectural studies of macrophages, regulatory T cells and microvessel density on diagnostic biopsies of uniformly treated FL patients significantly predicted clinical outcome and, importantly, also informed on the risk of transformation. Techniques that enabled the use of routine formalin fixed paraffin embedded diagnostic specimens from the pathology department archives were preferentially used in this thesis with the goal of fulfilling a rapid bench-to-beside” translation for these new findings. Although FL was the main subject of the thesis the new findings and hypotheses allowed easy transition into other lymphoma types. Several promising biomarkers were proposed and validated including the implication of several non-neoplastic immune cells as important contributors to lymphoma biology, opening new options for better treatment planning and eventually new therapeutic targets and candidate therapeutics

    An integrated approach to value chain analysis of end of life aircraft treatment

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    Dans cette thèse, on propose une approche holistique pour l’analyse, la modélisation et l’optimisation des performances de la chaîne de valeur pour le traitement des avions en fin de vie (FdV). Les recherches réalisées ont débouché sur onze importantes contributions. Dans la première contribution, on traite du contexte, de la complexité, de la diversité et des défis du recyclage d’avions en FdV. La seconde contribution traite du problème de la prédiction du nombre de retraits d’avions et propose une approche intégrée pour l’estimation de ce nombre de retraits. Le troisième et le quatrième articles visent à identifier les parties prenantes, les valeurs perçues par chaque partenaire et indiquent comment cette valeur peut affecter les décisions au stade de la conception. Les considérations relatives à la conception et à la fabrication ont donné lieu à quatre contributions importantes. La cinquième contribution traite des défis et opportunités pouvant résulter de l’application des concepts de la chaîne logistique verte, pour les manufacturiers d’avions. Dans la sixième contribution, un outil d’aide à la décision a été développé pour choisir la stratégie verte qui optimise les performances globales de de toute la chaîne de valeur en tenant compte des priorités et contraintes de chaque partenaire. Dans la septième contribution, un modèle mathématique est proposé pour analyser le choix stratégique des manufacturiers en réponse aux directives en matière de FdV de produits comme le résultat des interactions des compétiteurs dans le marché. La huitième contribution porte sur les travaux réalisés dans le cadre d’un stage chez le constructeur d’avions, Bombardier. Cette dernière traite de l’apport de « l’analyse du cycle de vie » au stade de la conception d’avions. La neuvième contribution introduit une méthodologie d’analyse de la chaîne de valeur dans un contexte de développement durable. Finalement, les dixième et onzième contributions proposent une approche holistique pour le traitement des avions en FdV en intégrant les concepts du « lean », du développement durable et des contraintes et opportunités inhérentes à la mondialisation des affaires. Un modèle d’optimisation intégrant les modèles d’affaires, les stratégies de désassemblage et les structures du réseau qui influencent l’efficacité, la stabilité et l’agilité du réseau de récupération est proposé. Les données requises pour exploiter le modèle sont indiquées dans l’article. Mots-clés: Fin de vie des avions, analyse de la chaîne de valeurs, développement durable, intervenants.The number of aircrafts at the end of life (EOL) is continuously increasing. Dealing with retired aircrafts considering the environmental, social and economic impacts is becoming an emerging problem in the aviation industry in near future. This thesis seeks to develop a holistic approach in order to analyze the value chain of EOL aircraft treatment in the context of sustainable development. The performed researches have led to eleven main contributions. In the first contribution, the complexity and diversity of the EOL aircraft recycling including the challenges and problem context are discussed. The second contribution addresses the challenges for estimation of retired aircrafts and proposes an integrated approach for prediction of EOL aircrafts. The third and fourth contributions aim to identify the players involved in EOL recycling context, values perceived by different shareholders and formulate that how such value can affect design decisions. Design stage consideration and manufacture’s issues are discussed and have led to four main contributions. The fifth contribution addresses the opportunities and challenges of applying green supply chain for aircraft manufacturers. In the sixth contribution, a decision tool is developed to aid manufactures in early stage of design for their green strategy choices. In the seventh contribution, a mathematical model is developed in order to analyze the strategic choice of manufacturers in response to EOL directives as the result of the interaction of competitors in the market. An internship project has been also performed in Bombardier and led to the eighth contribution, which addresses life cycle approach and incorporating the sustainability in early stage of design of aircraft. The ninth contribution introduces a methodology for analyzing the value chain in the context of sustainable development. Finally, the tenth and eleventh contributions propose a holistic approach to EOL aircraft treatment considering lean principals, sustainable development, and global business environment. An optimization model is developed to support decision making in both strategic and managerial level. The analytical approaches, decision tools and step by step guidelines proposed in this thesis will aid decision makers to identify appropriate strategies for the EOL aircraft treatment in the sustainable development context. Keywords: End of life aircraft, value chain analysis, sustainable development, stakeholders

    Pertanika Journal of Science & Technology

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    Pertanika Journal of Science & Technology

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    Systematic Approaches for Telemedicine and Data Coordination for COVID-19 in Baja California, Mexico

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    Conference proceedings info: ICICT 2023: 2023 The 6th International Conference on Information and Computer Technologies Raleigh, HI, United States, March 24-26, 2023 Pages 529-542We provide a model for systematic implementation of telemedicine within a large evaluation center for COVID-19 in the area of Baja California, Mexico. Our model is based on human-centric design factors and cross disciplinary collaborations for scalable data-driven enablement of smartphone, cellular, and video Teleconsul-tation technologies to link hospitals, clinics, and emergency medical services for point-of-care assessments of COVID testing, and for subsequent treatment and quar-antine decisions. A multidisciplinary team was rapidly created, in cooperation with different institutions, including: the Autonomous University of Baja California, the Ministry of Health, the Command, Communication and Computer Control Center of the Ministry of the State of Baja California (C4), Colleges of Medicine, and the College of Psychologists. Our objective is to provide information to the public and to evaluate COVID-19 in real time and to track, regional, municipal, and state-wide data in real time that informs supply chains and resource allocation with the anticipation of a surge in COVID-19 cases. RESUMEN Proporcionamos un modelo para la implementación sistemática de la telemedicina dentro de un gran centro de evaluación de COVID-19 en el área de Baja California, México. Nuestro modelo se basa en factores de diseño centrados en el ser humano y colaboraciones interdisciplinarias para la habilitación escalable basada en datos de tecnologías de teleconsulta de teléfonos inteligentes, celulares y video para vincular hospitales, clínicas y servicios médicos de emergencia para evaluaciones de COVID en el punto de atención. pruebas, y para el tratamiento posterior y decisiones de cuarentena. Rápidamente se creó un equipo multidisciplinario, en cooperación con diferentes instituciones, entre ellas: la Universidad Autónoma de Baja California, la Secretaría de Salud, el Centro de Comando, Comunicaciones y Control Informático. de la Secretaría del Estado de Baja California (C4), Facultades de Medicina y Colegio de Psicólogos. Nuestro objetivo es proporcionar información al público y evaluar COVID-19 en tiempo real y rastrear datos regionales, municipales y estatales en tiempo real que informan las cadenas de suministro y la asignación de recursos con la anticipación de un aumento de COVID-19. 19 casos.ICICT 2023: 2023 The 6th International Conference on Information and Computer Technologieshttps://doi.org/10.1007/978-981-99-3236-
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