29,585 research outputs found
Pattern vectors from algebraic graph theory
Graphstructures have proven computationally cumbersome for pattern analysis. The reason for this is that, before graphs can be converted to pattern vectors, correspondences must be established between the nodes of structures which are potentially of different size. To overcome this problem, in this paper, we turn to the spectral decomposition of the Laplacian matrix. We show how the elements of the spectral matrix for the Laplacian can be used to construct symmetric polynomials that are permutation invariants. The coefficients of these polynomials can be used as graph features which can be encoded in a vectorial manner. We extend this representation to graphs in which there are unary attributes on the nodes and binary attributes on the edges by using the spectral decomposition of a Hermitian property matrix that can be viewed as a complex analogue of the Laplacian. To embed the graphs in a pattern space, we explore whether the vectors of invariants can be embedded in a low- dimensional space using a number of alternative strategies, including principal components analysis ( PCA), multidimensional scaling ( MDS), and locality preserving projection ( LPP). Experimentally, we demonstrate that the embeddings result in well- defined graph clusters. Our experiments with the spectral representation involve both synthetic and real- world data. The experiments with synthetic data demonstrate that the distances between spectral feature vectors can be used to discriminate between graphs on the basis of their structure. The real- world experiments show that the method can be used to locate clusters of graphs
Graph edit distance from spectral seriation
This paper is concerned with computing graph edit distance. One of the criticisms that can be leveled at existing methods for computing graph edit distance is that they lack some of the formality and rigor of the computation of string edit distance. Hence, our aim is to convert graphs to string sequences so that string matching techniques can be used. To do this, we use a graph spectral seriation method to convert the adjacency matrix into a string or sequence order. We show how the serial ordering can be established using the leading eigenvector of the graph adjacency matrix. We pose the problem of graph-matching as a maximum a posteriori probability (MAP) alignment of the seriation sequences for pairs of graphs. This treatment leads to an expression in which the edit cost is the negative logarithm of the a posteriori sequence alignment probability. We compute the edit distance by finding the sequence of string edit operations which minimizes the cost of the path traversing the edit lattice. The edit costs are determined by the components of the leading eigenvectors of the adjacency matrix and by the edge densities of the graphs being matched. We demonstrate the utility of the edit distance on a number of graph clustering problems
Modeling and visualizing uncertainty in gene expression clusters using Dirichlet process mixtures
Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data, little attention has been paid to uncertainty in the results obtained. Dirichlet process mixture (DPM) models provide a nonparametric Bayesian alternative to the bootstrap approach to modeling uncertainty in gene expression clustering. Most previously published applications of Bayesian model-based clustering methods have been to short time series data. In this paper, we present a case study of the application of nonparametric Bayesian clustering methods to the clustering of high-dimensional nontime series gene expression data using full Gaussian covariances. We use the probability that two genes belong to the same cluster in a DPM model as a measure of the similarity of these gene expression profiles. Conversely, this probability can be used to define a dissimilarity measure, which, for the purposes of visualization, can be input to one of the standard linkage algorithms used for hierarchical clustering. Biologically plausible results are obtained from the Rosetta compendium of expression profiles which extend previously published cluster analyses of this data
From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.doi:10.1371/journal.pcbi.1000341DNA–protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA–protein interactions is a challenging problem. Here, we present a novel computational approach for predicting DNA-binding protein residues and DNA–protein interaction modes without knowing its specific DNA target sequence. Given the structure of a DNA-binding protein, the method first generates an ensemble of complex structures obtained by rigid-body docking with a nonspecific canonical B-DNA. Representative models are subsequently selected through clustering and ranking by their DNA–protein interfacial energy. Analysis of these encounter complex models suggests that the recognition sites for specific DNA binding are usually favorable interaction sites for the nonspecific DNA probe and that nonspecific DNA–protein interaction modes exhibit some similarity to specific DNA–protein binding modes. Although the method requires as input the knowledge that the protein binds DNA, in benchmark tests, it achieves better performance in identifying DNA-binding sites than three previously established methods, which are based on sophisticated machine-learning techniques. We further apply our method to protein structures predicted through modeling and demonstrate that our method performs satisfactorily on protein models whose root-mean-square Ca deviation from native is up to 5 Å from their native structures. This study provides valuable structural insights into how a specific DNA-binding protein interacts with a nonspecific DNA sequence. The similarity between the specific DNA–protein interaction mode and nonspecific interaction modes may reflect an important sampling step in search of its specific DNA targets by a DNA-binding protein
Analyzing the Social Structure and Dynamics of E-mail and Spam in Massive Backbone Internet Traffic
E-mail is probably the most popular application on the Internet, with
everyday business and personal communications dependent on it. Spam or
unsolicited e-mail has been estimated to cost businesses significant amounts of
money. However, our understanding of the network-level behavior of legitimate
e-mail traffic and how it differs from spam traffic is limited. In this study,
we have passively captured SMTP packets from a 10 Gbit/s Internet backbone link
to construct a social network of e-mail users based on their exchanged e-mails.
The focus of this paper is on the graph metrics indicating various structural
properties of e-mail networks and how they evolve over time. This study also
looks into the differences in the structural and temporal characteristics of
spam and non-spam networks. Our analysis on the collected data allows us to
show several differences between the behavior of spam and legitimate e-mail
traffic, which can help us to understand the behavior of spammers and give us
the knowledge to statistically model spam traffic on the network-level in order
to complement current spam detection techniques.Comment: 15 pages, 20 figures, technical repor
Development of Computer Science Disciplines - A Social Network Analysis Approach
In contrast to many other scientific disciplines, computer science considers
conference publications. Conferences have the advantage of providing fast
publication of papers and of bringing researchers together to present and
discuss the paper with peers. Previous work on knowledge mapping focused on the
map of all sciences or a particular domain based on ISI published JCR (Journal
Citation Report). Although this data covers most of important journals, it
lacks computer science conference and workshop proceedings. That results in an
imprecise and incomplete analysis of the computer science knowledge. This paper
presents an analysis on the computer science knowledge network constructed from
all types of publications, aiming at providing a complete view of computer
science research. Based on the combination of two important digital libraries
(DBLP and CiteSeerX), we study the knowledge network created at
journal/conference level using citation linkage, to identify the development of
sub-disciplines. We investigate the collaborative and citation behavior of
journals/conferences by analyzing the properties of their co-authorship and
citation subgraphs. The paper draws several important conclusions. First,
conferences constitute social structures that shape the computer science
knowledge. Second, computer science is becoming more interdisciplinary. Third,
experts are the key success factor for sustainability of journals/conferences
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