603 research outputs found
Entropy of complex relevant components of Boolean networks
Boolean network models of strongly connected modules are capable of capturing
the high regulatory complexity of many biological gene regulatory circuits. We
study numerically the previously introduced basin entropy, a parameter for the
dynamical uncertainty or information storage capacity of a network as well as
the average transient time in random relevant components as a function of their
connectivity. We also demonstrate that basin entropy can be estimated from
time-series data and is therefore also applicable to non-deterministic networks
models.Comment: 8 pages, 6 figure
Evolving Gene Regulatory Networks with Mobile DNA Mechanisms
This paper uses a recently presented abstract, tuneable Boolean regulatory
network model extended to consider aspects of mobile DNA, such as transposons.
The significant role of mobile DNA in the evolution of natural systems is
becoming increasingly clear. This paper shows how dynamically controlling
network node connectivity and function via transposon-inspired mechanisms can
be selected for in computational intelligence tasks to give improved
performance. The designs of dynamical networks intended for implementation
within the slime mould Physarum polycephalum and for the distributed control of
a smart surface are considered.Comment: 7 pages, 8 figures. arXiv admin note: substantial text overlap with
arXiv:1303.722
Boolean networks synchronism sensitivity and XOR circulant networks convergence time
In this paper are presented first results of a theoretical study on the role
of non-monotone interactions in Boolean automata networks. We propose to
analyse the contribution of non-monotony to the diversity and complexity in
their dynamical behaviours according to two axes. The first one consists in
supporting the idea that non-monotony has a peculiar influence on the
sensitivity to synchronism of such networks. It leads us to the second axis
that presents preliminary results and builds an understanding of the dynamical
behaviours, in particular concerning convergence times, of specific
non-monotone Boolean automata networks called XOR circulant networks.Comment: In Proceedings AUTOMATA&JAC 2012, arXiv:1208.249
Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development
Progress in cell type reprogramming has revived the interest in Waddington's
concept of the epigenetic landscape. Recently researchers developed the
quasi-potential theory to represent the Waddington's landscape. The
Quasi-potential U(x), derived from interactions in the gene regulatory network
(GRN) of a cell, quantifies the relative stability of network states, which
determine the effort required for state transitions in a multi-stable dynamical
system. However, quasi-potential landscapes, originally developed for
continuous systems, are not suitable for discrete-valued networks which are
important tools to study complex systems. In this paper, we provide a framework
to quantify the landscape for discrete Boolean networks (BNs). We apply our
framework to study pancreas cell differentiation where an ensemble of BN models
is considered based on the structure of a minimal GRN for pancreas development.
We impose biologically motivated structural constraints (corresponding to
specific type of Boolean functions) and dynamical constraints (corresponding to
stable attractor states) to limit the space of BN models for pancreas
development. In addition, we enforce a novel functional constraint
corresponding to the relative ordering of attractor states in BN models to
restrict the space of BN models to the biological relevant class. We find that
BNs with canalyzing/sign-compatible Boolean functions best capture the dynamics
of pancreas cell differentiation. This framework can also determine the genes'
influence on cell state transitions, and thus can facilitate the rational
design of cell reprogramming protocols.Comment: 24 pages, 6 figures, 1 tabl
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