Graphical continuous Lyapunov models

The linear Lyapunov equation of a covariance matrix parametrizes the equilibrium covariance matrix of a stochastic process. This parametrization can be interpreted as a new graphical model class, and we show how the model class behaves under marginalization and introduce a method for structure learning via $\ell_1$-penalized loss minimization. Our proposed method is demonstrated to outperform alternative structure learning algorithms in a simulation study, and we illustrate its application for protein phosphorylation network reconstruction.Comment: 10 pages, 5 figure

Estimation and variable selection in a joint model of survival times and longitudinal outcomes with random effects

This paper considers a joint survival and mixed-effects model to explain the survival time from longitudinal data and high-dimensional covariates. The longitudinal data is modeled using a nonlinear effects model, where the regression function serves as a link function incorporated into a Cox model as a covariate. In that way, the longitudinal data is related to the survival time at a given time. Additionally, the Cox model takes into account the inclusion of high-dimensional covariates. The main objectives of this research are two-fold: first, to identify the relevant covariates that contribute to explaining survival time, and second, to estimate all unknown parameters of the joint model. For that purpose, we consider the maximization of a Lasso penalized likelihood. To tackle the optimization problem, we implement a pre-conditioned stochastic gradient to handle the latent variables of the nonlinear mixed-effects model associated with a proximal operator to manage the non-differentiability of the penalty. We provide relevant simulations that showcase the performance of the proposed variable selection and parameters' estimation method in the joint modeling of a Cox and logistic model

Model Consistency for Learning with Mirror-Stratifiable Regularizers

Low-complexity non-smooth convex regularizers are routinely used to impose some structure (such as sparsity or low-rank) on the coefficients for linear predictors in supervised learning. Model consistency consists then in selecting the correct structure (for instance support or rank) by regularized empirical risk minimization. It is known that model consistency holds under appropriate non-degeneracy conditions. However such conditions typically fail for highly correlated designs and it is observed that regularization methods tend to select larger models. In this work, we provide the theoretical underpinning of this behavior using the notion of mirror-stratifiable regularizers. This class of regularizers encompasses the most well-known in the literature, including the $\ell_1$ or trace norms. It brings into play a pair of primal-dual models, which in turn allows one to locate the structure of the solution using a specific dual certificate. We also show how this analysis is applicable to optimal solutions of the learning problem, and also to the iterates computed by a certain class of stochastic proximal-gradient algorithms.Comment: 14 pages, 4 figure