Stochastic Modeling and Performance Analysis of Energy-Aware Cloud Data Center Based on Dynamic Scalable Stochastic Petri Net

The characteristics of cloud computing, such as large-scale, dynamics, heterogeneity and diversity, present a range of challenges for the study on modeling and performance evaluation on cloud data centers. Performance evaluation not only finds out an appropriate trade-off between cost-benefit and quality of service (QoS) based on service level agreement (SLA), but also investigates the influence of virtualization technology. In this paper, we propose an Energy-Aware Optimization (EAO) algorithm with considering energy consumption, resource diversity and virtual machine migration. In addition, we construct a stochastic model for Energy-Aware Migration-Enabled Cloud (EAMEC) data centers by introducing Dynamic Scalable Stochastic Petri Net (DSSPN). Several performance parameters are defined to evaluate task backlogs, throughput, reject rate, utilization, and energy consumption under different runtime and machines. Finally, we use a tool called SPNP to simulate analytical solutions of these parameters. The analysis results show that DSSPN is applicable to model and evaluate complex cloud systems, and can help to optimize the performance of EAMEC data centers

Evaluating cloud database migration options using workload models

A key challenge in porting enterprise software systems to the cloud is the migration of their database. Choosing a cloud provider and service option (e.g., a database-as-a-service or a manually configured set of virtual machines) typically requires the estimation of the cost and migration duration for each considered option. Many organisations also require this information for budgeting and planning purposes. Existing cloud migration research focuses on the software components, and therefore does not address this need. We introduce a two-stage approach which accurately estimates the migration cost, migration duration and cloud running costs of relational databases. The first stage of our approach obtains workload and structure models of the database to be migrated from database logs and the database schema. The second stage performs a discrete-event simulation using these models to obtain the cost and duration estimates. We implemented software tools that automate both stages of our approach. An extensive evaluation compares the estimates from our approach against results from real-world cloud database migrations

Complexity in Developmental Systems: Toward an Integrated Understanding of Organ Formation

During animal development, embryonic cells assemble into intricately structured organs by working together in organized groups capable of implementing tightly coordinated collective behaviors, including patterning, morphogenesis and migration. Although many of the molecular components and basic mechanisms underlying such collective phenomena are known, the complexity emerging from their interplay still represents a major challenge for developmental biology. Here, we first clarify the nature of this challenge and outline three key strategies for addressing it: precision perturbation, synthetic developmental biology, and data-driven inference. We then present the results of our effort to develop a set of tools rooted in two of these strategies and to apply them to uncover new mechanisms and principles underlying the coordination of collective cell behaviors during organogenesis, using the zebrafish posterior lateral line primordium as a model system. To enable precision perturbation of migration and morphogenesis, we sought to adapt optogenetic tools to control chemokine and actin signaling. This endeavor proved far from trivial and we were ultimately unable to derive functional optogenetic constructs. However, our work toward this goal led to a useful new way of perturbing cortical contractility, which in turn revealed a potential role for cell surface tension in lateral line organogenesis. Independently, we hypothesized that the lateral line primordium might employ plithotaxis to coordinate organ formation with collective migration. We tested this hypothesis using a novel optical tool that allows targeted arrest of cell migration, finding that contrary to previous assumptions plithotaxis does not substantially contribute to primordium guidance. Finally, we developed a computational framework for automated single-cell segmentation, latent feature extraction and quantitative analysis of cellular architecture. We identified the key factors defining shape heterogeneity across primordium cells and went on to use this shape space as a reference for mapping the results of multiple experiments into a quantitative atlas of primordium cell architecture. We also propose a number of data-driven approaches to help bridge the gap from big data to mechanistic models. Overall, this study presents several conceptual and methodological advances toward an integrated understanding of complex multi-cellular systems