14,384 research outputs found
Extending Hybrid CSP with Probability and Stochasticity
Probabilistic and stochastic behavior are omnipresent in computer controlled
systems, in particular, so-called safety-critical hybrid systems, because of
fundamental properties of nature, uncertain environments, or simplifications to
overcome complexity. Tightly intertwining discrete, continuous and stochastic
dynamics complicates modelling, analysis and verification of stochastic hybrid
systems (SHSs). In the literature, this issue has been extensively
investigated, but unfortunately it still remains challenging as no promising
general solutions are available yet. In this paper, we give our effort by
proposing a general compositional approach for modelling and verification of
SHSs. First, we extend Hybrid CSP (HCSP), a very expressive and process
algebra-like formal modeling language for hybrid systems, by introducing
probability and stochasticity to model SHSs, which is called stochastic HCSP
(SHCSP). To this end, ordinary differential equations (ODEs) are generalized by
stochastic differential equations (SDEs) and non-deterministic choice is
replaced by probabilistic choice. Then, we extend Hybrid Hoare Logic (HHL) to
specify and reason about SHCSP processes. We demonstrate our approach by an
example from real-world.Comment: The conference version of this paper is accepted by SETTA 201
Statistical Model Checking for Stochastic Hybrid Systems
This paper presents novel extensions and applications of the UPPAAL-SMC model
checker. The extensions allow for statistical model checking of stochastic
hybrid systems. We show how our race-based stochastic semantics extends to
networks of hybrid systems, and indicate the integration technique applied for
implementing this semantics in the UPPAAL-SMC simulation engine. We report on
two applications of the resulting tool-set coming from systems biology and
energy aware buildings.Comment: In Proceedings HSB 2012, arXiv:1208.315
Programmable models of growth and mutation of cancer-cell populations
In this paper we propose a systematic approach to construct mathematical
models describing populations of cancer-cells at different stages of disease
development. The methodology we propose is based on stochastic Concurrent
Constraint Programming, a flexible stochastic modelling language. The
methodology is tested on (and partially motivated by) the study of prostate
cancer. In particular, we prove how our method is suitable to systematically
reconstruct different mathematical models of prostate cancer growth - together
with interactions with different kinds of hormone therapy - at different levels
of refinement.Comment: In Proceedings CompMod 2011, arXiv:1109.104
Hybrid performance modelling of opportunistic networks
We demonstrate the modelling of opportunistic networks using the process
algebra stochastic HYPE. Network traffic is modelled as continuous flows,
contact between nodes in the network is modelled stochastically, and
instantaneous decisions are modelled as discrete events. Our model describes a
network of stationary video sensors with a mobile ferry which collects data
from the sensors and delivers it to the base station. We consider different
mobility models and different buffer sizes for the ferries. This case study
illustrates the flexibility and expressive power of stochastic HYPE. We also
discuss the software that enables us to describe stochastic HYPE models and
simulate them.Comment: In Proceedings QAPL 2012, arXiv:1207.055
Learning and Designing Stochastic Processes from Logical Constraints
Stochastic processes offer a flexible mathematical formalism to model and
reason about systems. Most analysis tools, however, start from the premises
that models are fully specified, so that any parameters controlling the
system's dynamics must be known exactly. As this is seldom the case, many
methods have been devised over the last decade to infer (learn) such parameters
from observations of the state of the system. In this paper, we depart from
this approach by assuming that our observations are {\it qualitative}
properties encoded as satisfaction of linear temporal logic formulae, as
opposed to quantitative observations of the state of the system. An important
feature of this approach is that it unifies naturally the system identification
and the system design problems, where the properties, instead of observations,
represent requirements to be satisfied. We develop a principled statistical
estimation procedure based on maximising the likelihood of the system's
parameters, using recent ideas from statistical machine learning. We
demonstrate the efficacy and broad applicability of our method on a range of
simple but non-trivial examples, including rumour spreading in social networks
and hybrid models of gene regulation
Petri nets for systems and synthetic biology
We give a description of a Petri net-based framework for
modelling and analysing biochemical pathways, which uni¯es the qualita-
tive, stochastic and continuous paradigms. Each perspective adds its con-
tribution to the understanding of the system, thus the three approaches
do not compete, but complement each other. We illustrate our approach
by applying it to an extended model of the three stage cascade, which
forms the core of the ERK signal transduction pathway. Consequently
our focus is on transient behaviour analysis. We demonstrate how quali-
tative descriptions are abstractions over stochastic or continuous descrip-
tions, and show that the stochastic and continuous models approximate
each other. Although our framework is based on Petri nets, it can be
applied more widely to other formalisms which are used to model and
analyse biochemical networks
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