648 research outputs found
Learning and comparing functional connectomes across subjects
Functional connectomes capture brain interactions via synchronized
fluctuations in the functional magnetic resonance imaging signal. If measured
during rest, they map the intrinsic functional architecture of the brain. With
task-driven experiments they represent integration mechanisms between
specialized brain areas. Analyzing their variability across subjects and
conditions can reveal markers of brain pathologies and mechanisms underlying
cognition. Methods of estimating functional connectomes from the imaging signal
have undergone rapid developments and the literature is full of diverse
strategies for comparing them. This review aims to clarify links across
functional-connectivity methods as well as to expose different steps to perform
a group study of functional connectomes
Multiscale Dictionary Learning for Estimating Conditional Distributions
Nonparametric estimation of the conditional distribution of a response given
high-dimensional features is a challenging problem. It is important to allow
not only the mean but also the variance and shape of the response density to
change flexibly with features, which are massive-dimensional. We propose a
multiscale dictionary learning model, which expresses the conditional response
density as a convex combination of dictionary densities, with the densities
used and their weights dependent on the path through a tree decomposition of
the feature space. A fast graph partitioning algorithm is applied to obtain the
tree decomposition, with Bayesian methods then used to adaptively prune and
average over different sub-trees in a soft probabilistic manner. The algorithm
scales efficiently to approximately one million features. State of the art
predictive performance is demonstrated for toy examples and two neuroscience
applications including up to a million features
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