301 research outputs found

    Arquitectura vernácula y de cooperación. Transformación, continuidad, lecciones y aprendizajes en el contexto de Burkina Faso para un panorama de cambio

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    [ES] La arquitectura vernácula suele decirse adaptada al lugar y al modo de vida de sus habitantes. Pero las sociedades y sus culturas no son estáticas. El comportamiento y el entorno cambian y, con ellos, también la manera de construirlo. A la vez, este tipo de arquitectura ha reunido unas cualidades y alcanzado un grado de armonía entre naturaleza, construcción y comunidad que no siempre ha conseguido ser emulado por la profesión moderna de la arquitectura. Así, surge una contradicción aparente: cómo preservar el saber-hacer de estos entornos en el cambio. La síntesis entre conservación y adaptación parece resolverse en el aprendizaje: ¿qué lecciones de lo vernáculo es posible extraer y aplicar a la planificación contemporánea a pesar de las transformaciones? Para aproximarse a la respuesta, la investigación parte de antecedentes de estudio: sobre el contexto general de transformación del ámbito rural en un panorama donde el cambio parece inevitable; sobre la arquitectura vernácula, su estudio y cierta crítica a algunas tendencias de la modernidad; y sobre el contexto específico de la investigación en Burkina Faso. A partir de esta base, el trabajo se sitúa en dos escenarios: el de la arquitectura tradicional mossi en el pueblo de Baasneere (Región Centro-Norte), construida, habitada e inmersa en un proceso de cambio similar al de otros hábitats tradicionales en el país; el de la disciplina y profesión de la arquitectura modernas en Burkina Faso, con actitudes distintas hacia lo vernáculo a lo largo de las etapas históricas de urbanización del país. Cada escenario sugiere preguntas específicas de investigación que son abordadas mediante la revisión bibliográfica relativa a cada tema, el estudio de campo con observación participante, entrevistas abiertas y semiestructuradas, la documentación gráfica y la elaboración de fichas para registrar casos de viviendas tradicionales y sus cambios. En el primer escenario, la constatación de las transformaciones que afectan a la arquitectura vernácula, justificadas en cambios sociales y culturales, permite identificar algunos conflictos y lecciones. En el segundo escenario, un acercamiento de la disciplina hacia lo local es apreciado en determinadas tendencias definitivamente puestas en práctica en algunos casos de proyectos de cooperación al desarrollo. Parece ser en ese ámbito de trabajo donde algunas de las lecciones de lo vernáculo encuentran su aplicación más directa. Para terminar, el enfoque de la investigación se abre para proponer una reflexión sobre los puntos en común con otros contextos a nivel global. Si una determinada forma de progreso ha desencadenado modificaciones similares en los entornos rurales a nivel global, maneras alternativas de considerarlo deberían conducir a soluciones en común. En definitiva, la consideración de los entornos vernáculos, surgidos de relaciones de cooperación y simbiosis, podría tener la significación, en la primera mitad del siglo XXI, de despertar cierta conciencia de adecuación y mostrar vías posibles de acción para trabajar en la adaptación real de nuestros entornos y el arraigo de nuestras sociedades.[CA] L'arquitectura vernacla sol dir-se adaptada al lloc i a la manera de vida dels seus habitants. Però les societats i les seues cultures no són estàtiques. El comportament i l'entorn canvien i, amb ells, també la manera de construir-lo. Alhora, aquest tipus d'arquitectura ha reunit unes qualitats i aconseguit un grau d'harmonia entre naturalesa, construcció i comunitat que no sempre ha aconseguit ser emulat per la professió moderna de l'arquitectura. Així, sorgeix una contradicció aparent: com preservar el saber-fer d'aquests entorns en el canvi. La síntesi entre conservació i adaptació sembla resoldre's en l'aprenentatge: quines lliçons del vernacle és possible extraure i aplicar a la planificació contemporània malgrat les transformacions? Per a aproximar-se a la resposta, la investigació parteix d'antecedents d'estudi: sobre el context general de transformació de l'àmbit rural en un panorama on el canvi sembla inevitable; sobre l'arquitectura vernacla, el seu estudi i una certa crítica a algunes tendències de la modernitat; i sobre el context específic de la investigació a Burkina Faso. A partir d'aquesta base, el treball se situa en dos escenaris: el de l'arquitectura tradicional mossi al poble de Baasneere (Regió Centre-Nord), construïda, habitada i immersa en un procés de canvi similar al d'altres hàbitats tradicionals al país; el de la disciplina i professió de l'arquitectura modernes a Burkina Faso, amb actituds diferents cap al vernacle al llarg de les etapes històriques d'urbanització del país. Cada escenari suggereix preguntes específiques d'investigació que són abordades mitjançant la revisió bibliogràfica relativa a cada tema, l'estudi de camp amb observació participant, entrevistes obertes i semi-estructurades, la documentació gràfica i l'elaboració de fitxes per a registrar casos d'habitatges tradicionals i els seus canvis. En el primer escenari, la constatació de les transformacions que afecten l'arquitectura vernacla, justificades en canvis socials i culturals, permet identificar alguns conflictes i lliçons. En el segon escenari, un acostament de la disciplina cap al local és apreciat en determinades tendències definitivament posades en pràctica en alguns casos de projectes de cooperació al desenvolupament. Sembla ser en aquest àmbit de treball on algunes de les lliçons del vernacle troben la seua aplicació més directa. Per a acabar, l'enfocament de la investigació s'obri per a proposar una reflexió sobre els punts en comú amb altres contextos a nivell global. Si una determinada forma de progrés ha desencadenat modificacions similars en els entorns rurals a nivell global, maneres alternatives de considerar-ho haurien de conduir a solucions en comú. En definitiva, la consideració dels entorns vernacles, sorgits de relacions de cooperació i simbiosi, podria tindre la significació, en la primera meitat del segle XXI, de despertar una certa consciència d'adequació i mostrar vies possibles d'acció per a treballar en l'adaptació real dels nostres entorns i l'arrelament de les nostres societats.[EN] Vernacular architecture is often said to be adapted to the place and the way of life of its inhabitants. But societies and their cultures are not static. Behaviour and environment change and, with them, so does the way it is built. At the same time, this type of architecture has brought together qualities and achieved a degree of harmony between nature, building and community that has not always managed to be emulated by the modern architectural profession. Thus, an apparent contradiction arises: how to preserve the know-how of these environments in change. The synthesis between preservation and adaptation seems to be resolved in learning: what lessons from the vernacular can be drawn and applied to contemporary planning despite the transformations? To approach the answer, the research is based on a background of studies: on the general context of rural transformation in a perspective where change seems inevitable; on vernacular architecture, its study and some criticism of certain trends of modernity; and on the specific context of research in Burkina Faso. On this basis, the work is situated in two scenarios: that of traditional Mossi architecture in the village of Baasneere (Centre-North Region), built, inhabited and immersed in a process of change similar to that of other traditional habitats in the country; that of the modern discipline and profession of architecture in Burkina Faso, with different attitudes towards the vernacular throughout the historical periods of the country's urbanisation. Each scenario suggests specific research questions that are addressed by means of a literature review on each topic, a field study with participant observation, open and semi-structured interviews, graphic documentation, and the creation of sheets to record cases of traditional dwellings and their changes. In the first scenario, the observation of the transformations affecting vernacular architecture, justified by social and cultural changes, makes it possible to identify some conflicts and lessons. In the second scenario, a rapprochement of the discipline towards the local can be seen in certain tendencies, definitely put into practice in some cases of development cooperation projects. It seems to be in this field of work that some of the lessons of the vernacular find their most direct application. Finally, the research approach opens up to propose a reflection on the points in common with other contexts at the global level. If a particular form of progress has triggered similar changes in rural environments globally, alternative ways of looking at it should lead to common solutions. In short, the consideration of vernacular environments, arising from relations of cooperation and symbiosis, could have the significance, in the first half of the 21st century, of awakening a certain awareness of adequacy and showing possible ways of action to work on the real adaptation of our environments and the rootedness of our societies.Lidón De Miguel, M. (2022). Arquitectura vernácula y de cooperación. Transformación, continuidad, lecciones y aprendizajes en el contexto de Burkina Faso para un panorama de cambio [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/19145

    Real-time anomaly detection of gamma-ray bursts for the Cherenkov Telescope Array using deep learning

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    The Cherenkov Telescope Array (CTA) will be the next-generation ground-based observatory to study the universe in the very-high-energy domain. The observatory will rely on a Science Alert Generation (SAG) system to analyze the real-time data from the telescopes and generate science alerts. The SAG system will play a crucial role in the search and follow-up of transients from external alerts, enabling multi-wavelength and multi-messenger collaborations. It will maximize the potential for the detection of the rarest phenomena, such as gamma-ray bursts (GRBs), which are the science case for this study. This study presents an anomaly detection method based on deep learning for detecting gamma-ray burst events in real-time. The performance of the proposed method is evaluated and compared against the Li&Ma standard technique in two use cases of serendipitous discoveries and follow-up observations, using short exposure times. The method shows promising results in detecting GRBs and is flexible enough to allow real-time search for transient events on multiple time scales. The method does not assume background nor source models and doe not require a minimum number of photon counts to perform analysis, making it well-suited for real-time analysis. Future improvements involve further tests, relaxing some of the assumptions made in this study as well as post-trials correction of the detection significance. Moreover, the ability to detect other transient classes in different scenarios must be investigated for completeness. The system can be integrated within the SAG system of CTA and deployed on the onsite computing clusters. This would provide valuable insights into the method's performance in a real-world setting and be another valuable tool for discovering new transient events in real-time. Overall, this study makes a significant contribution to the field of astrophysics by demonstrating the effectiveness of deep learning-based anomaly detection techniques for real-time source detection in gamma-ray astronomy.Il Cherenkov Telescope Array (CTA) sarà l'osservatorio terrestre di prossima generazione per lo studio dell'universo nel dominio delle altissime energie. L'osservatorio sfrutterà il sistema software di Science Alert Generation (SAG) per l'analisi in tempo reale dei dati osservativi e per generare automaticamente allerte scientifiche. Il sistema SAG svolgerà un ruolo da protagonista nella ricerca e nel follow-up di fenomeni transienti a seguito di allerte esterne, consentendo collaborazioni multi-wavelength e multi-messenger. Massimizzerà la capacità di rilevare i fenomeni più rari, come i lampi di raggi gamma (GRBs), che sono il caso scientifico di questo studio. Questo studio presenta una tecnica di anomaly detection basata sul deep learning per la rilevazione in tempo reale di GRBs. Le prestazioni della tecnica proposta sono valutate e confrontate con la tecnica standard di Li&Ma, nei due casi d'uso scientifici di serendipitous discoveries e follow-up observations, considerando brevi tempi di esposizione. La tecnica proposta mostra risultati promettenti e è abbastanza flessibile da consentire la ricerca di eventi transienti su più tempi scala. Non necessita di fare ipotesi sui modelli del background e della sorgente e non richiede un numero minimo di conteggi di fotoni per eseguire l'analisi, rendendola adatta per l'analisi in tempo reale. Miglioramenti futuri includono ulteriori test, accantonando alcune delle ipotesi semplificative assunte in questo studio, così come la correzione post-trial della significatività di rilevazione. Inoltre, dovrà essere testata la capacità di rilevare altre classi di transienti oltre ai GRBs. L'integrazione all'interno del sistema SAG e la messa in produzione nei centri di calcolo onsite, fornirebbe preziose informazioni sulle prestazioni del metodo con dati non simulati. Nel complesso, questo studio fornisce un contributo significativo al campo dell'astrofisica delle alte energie e dimostra l'efficacia della tecnica di anomaly detection per la rilevazione in tempo reale di fenomeni transienti

    Enabling Resilient and Efficient Communication for the XRP Ledger and Interledger

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    The blockchain technology is relatively new and still evolving. Its development was fostered by an enthusiastic community of developers, which sometimes forgot about the lessons from the past related to security, resilience and efficiency of communication which can impact network scalability, service quality and even service availability. These challenges can be addressed at network level but also at operating system level. At network level, the protocols and the architecture used play a major role, and overlays have interesting advantages like custom protocols and the possibility of arbitrary deployments. This thesis shows how overlay networks can be designed and deployed to benefit the security and performance in communication for consensus-validation based blockchains and blockchain inter-operativity, taking as concrete cases the XRP ledger and respectively the Interledger protocol. XRP Ledger is a consensus-validation based blockchain focused on payments which currently uses a flooding mechanism for peer to peer communication, with a negative impact on scalability. One of the proposed overlays is based on Named Data Networking, an Internet architecture using for propagation the data name instead of data location. The second proposed overlay is based on Spines, a solution offering improved latency on lossy paths, intrusion tolerance and resilience to routing attacks. The system component was also interesting to study, and the contribution of this thesis centers around methodologies to evaluate the system performance of a node and increase the security from the system level. The value added by the presented work can be synthesized as follows: i) investigate and propose a Named Data Networking-based overlay solution to improve the efficiency of intra-blockchain communication at network level, taking as a working case the XRP Ledger; ii) investigate and propose an overlay solution based on Spines, which improves the security and resilience of inter-blockchain communication at network level, taking as a working case the Interledger protocol; iii) investigate and propose a host-level solution for non-intrusive instrumentation and monitoring which helps improve the performance and security of inter-blockchain communication at the system level of machines running Distributed Ledger infrastructure applications treated as black-boxes, with Interledger Connectors as a concrete case

    Naval Postgraduate School Academic Catalog - February 2023

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    Edge and Big Data technologies for Industry 4.0 to create an integrated pre-sale and after-sale environment

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    The fourth industrial revolution, also known as Industry 4.0, has rapidly gained traction in businesses across Europe and the world, becoming a central theme in small, medium, and large enterprises alike. This new paradigm shifts the focus from locally-based and barely automated firms to a globally interconnected industrial sector, stimulating economic growth and productivity, and supporting the upskilling and reskilling of employees. However, despite the maturity and scalability of information and cloud technologies, the support systems already present in the machine field are often outdated and lack the necessary security, access control, and advanced communication capabilities. This dissertation proposes architectures and technologies designed to bridge the gap between Operational and Information Technology, in a manner that is non-disruptive, efficient, and scalable. The proposal presents cloud-enabled data-gathering architectures that make use of the newest IT and networking technologies to achieve the desired quality of service and non-functional properties. By harnessing industrial and business data, processes can be optimized even before product sale, while the integrated environment enhances data exchange for post-sale support. The architectures have been tested and have shown encouraging performance results, providing a promising solution for companies looking to embrace Industry 4.0, enhance their operational capabilities, and prepare themselves for the upcoming fifth human-centric revolution

    Diseño, obtención y caracterización de proteínas recombinantes a partir de determinantes antigénicos asociadas a reacciones alérgicas a ß-lactámicos.

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    Tesis por compendio[ES] El diagnóstico de alergias a antibióticos ß-lactámicos incluye el uso de pruebas in vivo no satisfactorias ya que consumen mucho tiempo y conllevan el riesgo de provocar una nueva reacción alérgica. Por otro lado, los métodos in vitro basados en la inmunodetección de IgE alérgeno-específica generan una información muy valiosa, confirmando o descartando la alergia y postulándose como una alternativa de diagnóstico segura. A pesar de ello, las pruebas in vitro actuales carecen de sensibilidad y exactitud, con un 81% de falsos negativos, lo que limita su uso diagnóstico. Esto ha desencadenado una creciente demanda de nuevas pruebas in vitro basadas en la inmunodetección de IgE, el biomarcador presente en suero más estudiado en alergia. Sin embargo, la falta de estándares de referencia de IgE alérgeno-específica ha imposibilitado la validación y estandarización de los métodos, lo que hace que los resultados de las distintas pruebas no sean comparables. Además, dicha falta de estándares de referencia hace que las concentraciones de IgE específica se calculen a partir de una curva de calibración de IgE total mediante una interpolación heteróloga, lo que ha demostrado no ser totalmente correcto. Por los motivos mencionados, en esta tesis doctoral se plantea como objetivo principal el diseño, obtención y caracterización de proteínas recombinantes con reactividad frente a antibióticos ß-lactámicos. Esta investigación comienza con la puesta a punto de un inmunoensayo en placa ELISA con detección quimioluminiscente para la cuantificación de IgE específica. El ensayo desarrollado permitió determinar IgE específica por debajo de 0.1 IU/mL (0.24 ng/mL), permitiendo así la identificación de pacientes alérgicos con una mayor sensibilidad, utilizando solo 25 ¿L de muestra (suero). El inmunoensayo mostró una buena sensibilidad (64.6%), así como una excelente especificidad (100%), que mejoran significativamente el carácter predictivo de las pruebas in vitro existentes. A continuación, se abordó la obtención y caracterización de proteínas recombinantes similares a las IgE específicas de los ß-lactámicos utilizando la metodología Phage Display. La primera aproximación se trata de una proteína formada por dos nanoanticuerpos que mimetiza el comportamiento de una IgE específica. De esta manera, se obtuvieron proteínas recombinantes en las que uno de los nanoanticuerpos reconoce selectivamente un determinante antigénico de un antibiótico ß-lactámico, mientras que el otro reconoce específicamente al parátopo de un anticuerpo detector anti-IgE. Estas construcciones resultaron ser estables y funcionales. El papel de estas proteínas recombinantes como calibrador homólogo se estudió determinando la concentración de IgE específica a penicilina G presente en suero mediante un ensayo quimioluminiscente. El método desarrollado duplicaba la sensibilidad clínica (66%) frente al método de referencia (28%), mientras que mantenía una especificidad clínica del 100%. Alcanzado este punto, la tesis se centró en la producción de IgE específica recombinante utilizando como material de partida el ADN de un paciente alérgico a amoxicilina y penicilina G. A partir del material genético aislado, mediante Phage Display, ingeniería de anticuerpos y métodos de expresión en células de insecto se consiguió producir una IgE específica recombinante. De esta manera, se obtuvo un producto biológico que cumple con los requisitos para su adopción como material de referencia en ensayos in vitro. Igualmente, se utilizó como calibrador homólogo para la determinación de IgE específica a amoxicilina. Se alcanzó un límite de detección de 0.05 IU/mL con el que se conseguía un aumento de la sensibilidad clínica (73%) que cuadruplicaba al método de referencia (16%), manteniendo la especificidad clínica en el 100%.[CA] El diagnòstic d'al·lèrgies a antibiòtics ß-lactàmics inclou l'ús de proves in vivo no satisfactòries, ja que consumeixen molt de temps i comporten el risc de provocar una nova reacció al·lèrgica. D'altra banda, els mètodes in vitro basats en la immunodetecció d'IgE al·lergen-específica generen una informació molt valuosa, confirmant o descartant l'al·lèrgia i postulant-se com una alternativa de diagnòstic segura. Tanmateix, a les proves in vitro actuals hi ha una manca de sensibilitat i exactitud, amb un 81% de falsos negatius, cosa que en limita l'ús diagnòstic. Tot això ha desembocat en una demanda creixent de noves proves in vitro basades en la immunodetecció d'IgE, el biomarcador present en sèrum més estudiat en al·lèrgia. No obstant això, la manca d'estàndards de referència d'IgE al·lergen-específica ha impossibilitat la validació i estandardització dels mètodes, cosa que fa que els resultats de les diferents proves no siguen comparables. A més, aquesta manca d'estàndards de referència fa que les concentracions d'IgE específica es calculen a partir d'una corba de calibratge d'IgE total mitjançant una interpolació heteròloga, un mètode que ha demostrat no ser totalment correcte ja que no es pren en consideració la interacció entre el determinant antigènic i la IgE específica. Pels motius mencionats, en aquesta tesi doctoral es planteja com a objectiu principal el disseny, l'obtenció i la caracterització de proteïnes recombinants amb reactivitat davant dels antibiòtics ß-lactàmics. Aquesta investigació comença amb la posada a punt d'un immunoassaig en placa ELISA amb detecció quimioluminiscent per a la quantificació d'IgE específica. L'assaig desenvolupat va permetre determinar IgE específica per baix de 0.1 IU/mL (0.24 ng/mL), el que permet la identificació de pacients al·lèrgics amb més sensibilitat, utilitzant només 25 ¿L de mostra (sèrum). L'immunoassaig mostra una bona sensibilitat (64.6%), així com una excel·lent especificitat (100%), que milloren significativament el caràcter predictiu de les proves in vitro existents. A continuació, es va abordar l'obtenció i la caracterització de proteïnes recombinants similars a les IgE específiques dels ß-lactàmics utilitzant la metodologia Phage Display. La primera aproximació és una proteïna formada per dos nanoanticossos que mimetitza el comportament d'una IgE específica. D'aquesta manera, es van obtenir proteïnes recombinants en què un dels nanoanticossos reconeix selectivament un determinant antigènic d'un antibiòtic ß-lactàmic, mentre que l'altre reconeix específicament el paràtop d'un anticòs detector anti-IgE (Omalizumab). Aquestes construccions van resultar estables i funcionals. El paper d'aquestes proteïnes recombinants com a calibrador homòleg es va estudiar determinant la concentració d'IgE específica a penicil·lina G present en sèrum mitjançant un assaig quimioluminiscent. El mètode desenvolupat duplicava la sensibilitat clínica (66%) respecte del mètode de referència (28%), mentre que mantenia una especificitat clínica del 100%. Assolit aquest punt, la tesi es va centrar en la producció d'IgE específica recombinant utilitzant com a material de partida l'ADN d'un pacient al·lèrgic a amoxicil·lina i penicil·lina G. En combinació amb la metodologia Phage Display, enginyeria d'anticossos i mètodes d'expressió en cèl·lules d'insecte, es va aconseguir produir una IgE específica recombinant. D'aquesta manera, es va obtenir un producte biològic que compleix els requisits per ser adoptat com a material de referència en assajos in vitro. Igualment, es va utilitzar com a calibrador homòleg per a la determinació d'IgE específica a amoxicil·lina. Es va assolir un límit de detecció de 0.05 IU/mL amb què s'aconseguia un augment de la sensibilitat clínica (73%) que quadriplicava al mètode de referència (16%), mantenint l'especificitat clínica al 100%.[EN] The diagnosis of ß-lactam antibiotics allergy involves using unsatisfactory in vivo tests that are time-consuming and carry the risk of triggering a new allergic reaction. On the other hand, in vitro methods based on allergen-specific IgE immunodetection generate precious information, confirming or ruling out allergies and postulating themselves as a safe diagnostic alternative. Despite this, current in vitro tests lack sensitivity and accuracy, with 81% false negatives limiting their diagnostic use. This has led to a growing demand for new in vitro tests based on the immunodetection of IgE, the most studied biomarker in serum allergy. However, the lack of reference standards for allergen-specific IgE has made it impossible to validate and standardize methods, which means that the results of the different tests are not comparable. Furthermore, this lack of reference standards means that specific IgE concentrations are calculated from a total IgE calibration curve by heterologous interpolation, which has been shown not to be entirely correct. For the reasons mentioned above, the main objective of this doctoral thesis is to design, obtain and characterize recombinant proteins with reactivity against ß-lactam antibiotics. This research begins with developing an ELISA immunoassay with chemiluminescent detection for quantifying specific IgE. The assay developed allowed the determination of specific IgE below 0.1 IU/mL (0.24 ng/mL), thus allowing the identification of allergic patients with greater sensitivity, using only 25 µL of sample (serum). The immunoassay showed good sensitivity (64.6%) and excellent specificity (100%), significantly improving the predictive character of existing in vitro tests. Next, the obtaining and characterizing recombinant proteins similar to ß-lactam-specific IgE was approached using the Phage Display methodology. The first approach deals with a protein consisting of two single-domain antibodies that mimics the behavior of a specific IgE. In this way, recombinant proteins were obtained in which one of the nanobodies selectively recognizes an antigenic determinant of a ß-lactam antibiotic, while the other specifically recognizes the paratope of an anti-IgE detector antibody. These constructs were found to be stable and functional. The role of these recombinant proteins as a homologous calibrator was studied by determining the concentration of penicillin G-specific IgE present in serum by employing a chemiluminescent assay. The developed method doubled the clinical sensitivity (66%) compared to the reference method (28%), while maintaining a clinical specificity of 100%. At this point, the thesis focused on the production of recombinant specific IgE using as starting material the DNA of a patient allergic to amoxicillin and penicillin G. in combination with the Phage Display, antibody engineering and expression methods in insect cells, a recombinant-specific IgE was produced. In this way, a biological product was obtained that meets the requirements for its adoption as reference material in in vitro assays. Likewise, it was used as a homologous calibrator for the determination of specific IgE to amoxicillin. A detection limit of 0.05 IU/mL was achieved, which increased clinical sensitivity (73%) fourfold compared to the reference method (16%), while maintaining clinical specificity at 100%.This work was supported by CSIC 2007-348, ANII FMV 2019_156321, and ANII FMV 2018_148245. P.Q.-C. acknowledges financial support from Generalitat Valenciana through the research staff training program (GVA ACIF/2018/173). This research was also funded by Agencia Estatal de Investigación (PID2019-110713RB-I00, FEDER), program UPV-La FE 2019 (P105 VALBIOAL), and PROMETEO/ 2020/094Quintero Campos, P. (2022). Diseño, obtención y caracterización de proteínas recombinantes a partir de determinantes antigénicos asociadas a reacciones alérgicas a ß-lactámicos [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/191429Compendi

    Expanding the Horizons of Manufacturing: Towards Wide Integration, Smart Systems and Tools

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    This research topic aims at enterprise-wide modeling and optimization (EWMO) through the development and application of integrated modeling, simulation and optimization methodologies, and computer-aided tools for reliable and sustainable improvement opportunities within the entire manufacturing network (raw materials, production plants, distribution, retailers, and customers) and its components. This integrated approach incorporates information from the local primary control and supervisory modules into the scheduling/planning formulation. That makes it possible to dynamically react to incidents that occur in the network components at the appropriate decision-making level, requiring fewer resources, emitting less waste, and allowing for better responsiveness in changing market requirements and operational variations, reducing cost, waste, energy consumption and environmental impact, and increasing the benefits. More recently, the exploitation of new technology integration, such as through semantic models in formal knowledge models, allows for the capture and utilization of domain knowledge, human knowledge, and expert knowledge toward comprehensive intelligent management. Otherwise, the development of advanced technologies and tools, such as cyber-physical systems, the Internet of Things, the Industrial Internet of Things, Artificial Intelligence, Big Data, Cloud Computing, Blockchain, etc., have captured the attention of manufacturing enterprises toward intelligent manufacturing systems

    EVOLUTION OF THE SUBCONTINENTAL LITHOSPHERE DURING MESOZOIC TETHYAN RIFTING: CONSTRAINTS FROM THE EXTERNAL LIGURIAN MANTLE SECTION (NORTHERN APENNINE, ITALY)

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    Our study is focussed on mantle bodies from the External Ligurian ophiolites, within the Monte Gavi and Monte Sant'Agostino areas. Here, two distinct pyroxenite-bearing mantle sections were recognized, mainly based on their plagioclase-facies evolution. The Monte Gavi mantle section is nearly undeformed and records reactive melt infiltration under plagioclase-facies conditions. This process involved both peridotites (clinopyroxene-poor lherzolites) and enclosed spinel pyroxenite layers, and occurred at 0.7–0.8 GPa. In the Monte Gavi peridotites and pyroxenites, the spinel-facies clinopyroxene was replaced by Ca-rich plagioclase and new orthopyroxene, typically associated with secondary clinopyroxene. The reactive melt migration caused increase of TiO2 contents in relict clinopyroxene and spinel, with the latter also recording a Cr2O3 increase. In the Monte Gavi peridotites and pyroxenites, geothermometers based on slowly diffusing elements (REE and Y) record high temperature conditions (1200-1250 °C) related to the melt infiltration event, followed by subsolidus cooling until ca. 900°C. The Monte Sant'Agostino mantle section is characterized by widespread ductile shearing with no evidence of melt infiltration. The deformation recorded by the Monte Sant'Agostino peridotites (clinopyroxene-rich lherzolites) occurred at 750–800 °C and 0.3–0.6 GPa, leading to protomylonitic to ultramylonitic textures with extreme grain size reduction (10–50 μm). Compared to the peridotites, the enclosed pyroxenite layers gave higher temperature-pressure estimates for the plagioclase-facies re-equilibration (870–930 °C and 0.8–0.9 GPa). We propose that the earlier plagioclase crystallization in the pyroxenites enhanced strain localization and formation of mylonite shear zones in the entire mantle section. We subdivide the subcontinental mantle section from the External Ligurian ophiolites into three distinct domains, developed in response to the rifting evolution that ultimately formed a Middle Jurassic ocean-continent transition: (1) a spinel tectonite domain, characterized by subsolidus static formation of plagioclase, i.e. the Suvero mantle section (Hidas et al., 2020), (2) a plagioclase mylonite domain experiencing melt-absent deformation and (3) a nearly undeformed domain that underwent reactive melt infiltration under plagioclase-facies conditions, exemplified by the the Monte Sant'Agostino and the Monte Gavi mantle sections, respectively. We relate mantle domains (1) and (2) to a rifting-driven uplift in the late Triassic accommodated by large-scale shear zones consisting of anhydrous plagioclase mylonites. Hidas K., Borghini G., Tommasi A., Zanetti A. & Rampone E. 2021. Interplay between melt infiltration and deformation in the deep lithospheric mantle (External Liguride ophiolite, North Italy). Lithos 380-381, 105855

    Energy Planning

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    The world needs an accelerated energy transition to meet sustainable development goals. Energy planning has a critical role in providing the information that can guide decision-makers, and energy planning methods continue to evolve rapidly. This Special Issue provides new insights for long-term energy planning, drawing on the Clean Energy Ministerial Long Term Energy Planning Scenarios initiative and the IRENA LTES network
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