5,507 research outputs found
Structure Learning in Coupled Dynamical Systems and Dynamic Causal Modelling
Identifying a coupled dynamical system out of many plausible candidates, each
of which could serve as the underlying generator of some observed measurements,
is a profoundly ill posed problem that commonly arises when modelling real
world phenomena. In this review, we detail a set of statistical procedures for
inferring the structure of nonlinear coupled dynamical systems (structure
learning), which has proved useful in neuroscience research. A key focus here
is the comparison of competing models of (ie, hypotheses about) network
architectures and implicit coupling functions in terms of their Bayesian model
evidence. These methods are collectively referred to as dynamical casual
modelling (DCM). We focus on a relatively new approach that is proving
remarkably useful; namely, Bayesian model reduction (BMR), which enables rapid
evaluation and comparison of models that differ in their network architecture.
We illustrate the usefulness of these techniques through modelling
neurovascular coupling (cellular pathways linking neuronal and vascular
systems), whose function is an active focus of research in neurobiology and the
imaging of coupled neuronal systems
Estimating effective connectivity in linear brain network models
Contemporary neuroscience has embraced network science to study the complex
and self-organized structure of the human brain; one of the main outstanding
issues is that of inferring from measure data, chiefly functional Magnetic
Resonance Imaging (fMRI), the so-called effective connectivity in brain
networks, that is the existing interactions among neuronal populations. This
inverse problem is complicated by the fact that the BOLD (Blood Oxygenation
Level Dependent) signal measured by fMRI represent a dynamic and nonlinear
transformation (the hemodynamic response) of neuronal activity. In this paper,
we consider resting state (rs) fMRI data; building upon a linear population
model of the BOLD signal and a stochastic linear DCM model, the model
parameters are estimated through an EM-type iterative procedure, which
alternately estimates the neuronal activity by means of the Rauch-Tung-Striebel
(RTS) smoother, updates the connections among neuronal states and refines the
parameters of the hemodynamic model; sparsity in the interconnection structure
is favoured using an iteratively reweighting scheme. Experimental results using
rs-fMRI data are shown demonstrating the effectiveness of our approach and
comparison with state of the art routines (SPM12 toolbox) is provided
Comparing families of dynamic causal models
Mathematical models of scientific data can be formally compared using Bayesian model evidence. Previous applications in the biological sciences have mainly focussed on model selection in which one first selects the model with the highest evidence and then makes inferences based on the parameters of that model. This “best model” approach is very useful but can become brittle if there are a large number of models to compare, and if different subjects use different models. To overcome this shortcoming we propose the combination of two further approaches: (i) family level inference and (ii) Bayesian model averaging within families. Family level inference removes uncertainty about aspects of model structure other than the characteristic of interest. For example: What are the inputs to the system? Is processing serial or parallel? Is it linear or nonlinear? Is it mediated by a single, crucial connection? We apply Bayesian model averaging within families to provide inferences about parameters that are independent of further assumptions about model structure. We illustrate the methods using Dynamic Causal Models of brain imaging data
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