12,134 research outputs found
Identifying dynamical systems with bifurcations from noisy partial observation
Dynamical systems are used to model a variety of phenomena in which the
bifurcation structure is a fundamental characteristic. Here we propose a
statistical machine-learning approach to derive lowdimensional models that
automatically integrate information in noisy time-series data from partial
observations. The method is tested using artificial data generated from two
cell-cycle control system models that exhibit different bifurcations, and the
learned systems are shown to robustly inherit the bifurcation structure.Comment: 16 pages, 6 figure
Training deep neural density estimators to identify mechanistic models of neural dynamics
Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of underlying causes. However, determining which model parameters agree with complex and stochastic neural data presents a significant challenge. We address this challenge with a machine learning tool which uses deep neural density estimators-- trained using model simulations-- to carry out Bayesian inference and retrieve the full space of parameters compatible with raw data or selected data features. Our method is scalable in parameters and data features, and can rapidly analyze new data after initial training. We demonstrate the power and flexibility of our approach on receptive fields, ion channels, and Hodgkin-Huxley models. We also characterize the space of circuit configurations giving rise to rhythmic activity in the crustacean stomatogastric ganglion, and use these results to derive hypotheses for underlying compensation mechanisms. Our approach will help close the gap between data-driven and theory-driven models of neural dynamics
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