Towards Real-time Wireless Sensor Networks

Wireless sensor networks are poised to change the way computer systems interact with the physical world. We plan on entrusting sensor systems to collect medical data from patients, monitor the safety of our infrastructure, and control manufacturing processes in our factories. To date, the focus of the sensor network community has been on developing best-effort services. This approach is insufficient for many applications since it does not enable developers to determine if a system\u27s requirements in terms of communication latency, bandwidth utilization, reliability, or energy consumption are met. The focus of this thesis is to develop real-time network support for such critical applications. The first part of the thesis focuses on developing a power management solution for the radio subsystem which addresses both the problem of idle-listening and power control. In contrast to traditional power management solutions which focus solely on reducing energy consumption, the distinguishing feature of our approach is that it achieves both energy efficiency and real-time communication. A solution to the idle-listening problem is proposed in Energy Efficient Sleep Scheduling based on Application Semantics: ESSAT). The novelty of ESSAT lies in that it takes advantage of the common features of data collection applications to determine when to turn on and off a node\u27s radio without affecting real-time performance. A solution to the power control problem is proposed in Real-time Power Aware-Routing: RPAR). RPAR tunes the transmission power for each packet based on its deadline such that energy is saved without missing packet deadlines. The main theoretical contribution of this thesis is the development of novel transmission scheduling techniques optimized for data collection applications. This work bridges the gap between wireless sensor networks and real-time scheduling theory, which have traditionally been applied to processor scheduling. The proposed approach has significant advantages over existing design methodologies:: 1) it provides predictable performance allowing for the performance of a system to be estimated upon its deployment,: 2) it is possible to detect and handle overload conditions through simple rate control mechanisms, and: 3) it easily accommodates workload changes. I developed this framework under a realistic interference model by coordinating the activities at the MAC, link, and routing layers. The last component of this thesis focuses on the development of a real-time patient monitoring system for general hospital units. The system is designed to facilitate the detection of clinical deterioration, which is a key factor in saving lives and reducing healthcare costs. Since patients in general hospital wards are often ambulatory, a key challenge is to achieve high reliability even in the presence of mobility. To support patient mobility, I developed the Dynamic Relay Association Protocol -- a simple and effective mechanism for dynamically discovering the right relays for forwarding patient data -- and a Radio Mapping Tool -- a practical tool for ensuring network coverage in 802.15.4 networks. We show that it is feasible to use low-power and low-cost wireless sensor networks for clinical monitoring through an in-depth clinical study. The study was performed in a step-down cardiac care unit at Barnes-Jewish Hospital. This is the first long-term study of such a patient monitoring system

PRELIMINARY FINDINGS OF A POTENZIATED PIEZOSURGERGICAL DEVICE AT THE RABBIT SKULL

The number of available ultrasonic osteotomes has remarkably increased. In vitro and in vivo studies have revealed differences between conventional osteotomes, such as rotating or sawing devices, and ultrasound-supported osteotomes (Piezosurgery®) regarding the micromorphology and roughness values of osteotomized bone surfaces. Objective: the present study compares the micro-morphologies and roughness values of osteotomized bone surfaces after the application of rotating and sawing devices, Piezosurgery Medical® and Piezosurgery Medical New Generation Powerful Handpiece. Methods: Fresh, standard-sized bony samples were taken from a rabbit skull using the following osteotomes: rotating and sawing devices, Piezosurgery Medical® and a Piezosurgery Medical New Generation Powerful Handpiece. The required duration of time for each osteotomy was recorded. Micromorphologies and roughness values to characterize the bone surfaces following the different osteotomy methods were described. The prepared surfaces were examined via light microscopy, environmental surface electron microscopy (ESEM), transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM) and atomic force microscopy. The selective cutting of mineralized tissues while preserving adjacent soft tissue (dura mater and nervous tissue) was studied. Bone necrosis of the osteotomy sites and the vitality of the osteocytes near the sectional plane were investigated, as well as the proportion of apoptosis or cell degeneration. Results and Conclusions: The potential positive effects on bone healing and reossification associated with different devices were evaluated and the comparative analysis among the different devices used was performed, in order to determine the best osteotomes to be employed during cranio-facial surgery

Proceedings of the Caltech Conference on Very Large Scale Integration, held at the California Institute of Technology 22 - 24 January 1979 ; Organized by the Caltech Computer Science Department and the Caltech Industrial Associates Office

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Treatment of Later Humoral Rejection with Anti-CD20 Monoclonal Antibody Rituximab: A Single Centre Experience

Humoral or vascular rejection is a B cell-mediated production of immunoglobulin (Ig) G antibody against a transplanted organ that results in immune complex deposition on the vascular endothelium, activation of the complement cascade, production of endothelial dysfunction and regional ischaemic injury