18,096 research outputs found

    Dimension-8 SMEFT Analysis of Minimal Scalar Field Extensions of the Standard Model

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    We analyze the constraints obtainable from present data using the Standard Model Effective Field Theory (SMEFT) on extensions of the Standard Model with additional electroweak singlet or triplet scalar fields. We compare results obtained using only contributions that are linear in dimension-6 operator coefficients with those obtained including terms quadratic in these coefficients as well as contributions that are linear in dimension-8 operator coefficients. We also implement theoretical constraints arising from the stability of the electroweak vacuum and perturbative unitarity. Analyzing the models at the dimension-8 level constrains scalar couplings that are not bounded at the dimension-6 level. The strongest experimental constraints on the singlet model are provided by Higgs coupling measurements, whereas electroweak precision observables provide the strongest constraints on the triplet model. In the singlet model the present di-Higgs constraints already play a significant role. We find that the current constraints on model parameters are already competitive with those anticipated from future di- and tri-Higgs measurements. We compare our results with calculations in the full model, exhibiting the improvements when higher-order SMEFT terms are included. We also identify regions in parameter space where the SMEFT approximation appears to break down. We find that the combination of current constraints with the theoretical bounds still admits regions where the SMEFT approach is not valid, particularly for lower scalar boson masses.Comment: 66 Pages, 14 Figures, 4 Table

    A hybrid quantum algorithm to detect conical intersections

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    Conical intersections are topologically protected crossings between the potential energy surfaces of a molecular Hamiltonian, known to play an important role in chemical processes such as photoisomerization and non-radiative relaxation. They are characterized by a non-zero Berry phase, which is a topological invariant defined on a closed path in atomic coordinate space, taking the value π\pi when the path encircles the intersection manifold. In this work, we show that for real molecular Hamiltonians, the Berry phase can be obtained by tracing a local optimum of a variational ansatz along the chosen path and estimating the overlap between the initial and final state with a control-free Hadamard test. Moreover, by discretizing the path into NN points, we can use NN single Newton-Raphson steps to update our state non-variationally. Finally, since the Berry phase can only take two discrete values (0 or π\pi), our procedure succeeds even for a cumulative error bounded by a constant; this allows us to bound the total sampling cost and to readily verify the success of the procedure. We demonstrate numerically the application of our algorithm on small toy models of the formaldimine molecule (\ce{H2C=NH}).Comment: 15 + 10 pages, 4 figure

    Countermeasures for the majority attack in blockchain distributed systems

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    La tecnología Blockchain es considerada como uno de los paradigmas informáticos más importantes posterior al Internet; en función a sus características únicas que la hacen ideal para registrar, verificar y administrar información de diferentes transacciones. A pesar de esto, Blockchain se enfrenta a diferentes problemas de seguridad, siendo el ataque del 51% o ataque mayoritario uno de los más importantes. Este consiste en que uno o más mineros tomen el control de al menos el 51% del Hash extraído o del cómputo en una red; de modo que un minero puede manipular y modificar arbitrariamente la información registrada en esta tecnología. Este trabajo se enfocó en diseñar e implementar estrategias de detección y mitigación de ataques mayoritarios (51% de ataque) en un sistema distribuido Blockchain, a partir de la caracterización del comportamiento de los mineros. Para lograr esto, se analizó y evaluó el Hash Rate / Share de los mineros de Bitcoin y Crypto Ethereum, seguido del diseño e implementación de un protocolo de consenso para controlar el poder de cómputo de los mineros. Posteriormente, se realizó la exploración y evaluación de modelos de Machine Learning para detectar software malicioso de tipo Cryptojacking.DoctoradoDoctor en Ingeniería de Sistemas y Computació

    A simplified lower bound for implicational logic

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    We present a streamlined and simplified exponential lower bound on the length of proofs in intuitionistic implicational logic, adapted to Gordeev and Haeusler's dag-like natural deduction.Comment: 31 page

    Mathematical models to evaluate the impact of increasing serotype coverage in pneumococcal conjugate vaccines

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    Of over 100 serotypes of Streptococcus pneumoniae, only 7 were included in the first pneumo- coccal conjugate vaccine (PCV). While PCV reduced the disease incidence, in part because of a herd immunity effect, a replacement effect was observed whereby disease was increasingly caused by serotypes not included in the vaccine. Dynamic transmission models can account for these effects to describe post-vaccination scenarios, whereas economic evaluations can enable decision-makers to compare vaccines of increasing valency for implementation. This thesis has four aims. First, to explore the limitations and assumptions of published pneu- mococcal models and the implications for future vaccine formulation and policy. Second, to conduct a trend analysis assembling all the available evidence for serotype replacement in Europe, North America and Australia to characterise invasive pneumococcal disease (IPD) caused by vaccine-type (VT) and non-vaccine-types (NVT) serotypes. The motivation behind this is to assess the patterns of relative abundance in IPD cases pre- and post-vaccination, to examine country-level differences in relation to the vaccines employed over time since introduction, and to assess the growth of the replacement serotypes in comparison with the serotypes targeted by the vaccine. The third aim is to use a Bayesian framework to estimate serotype-specific invasiveness, i.e. the rate of invasive disease given carriage. This is useful for dynamic transmission modelling, as transmission is through carriage but a majority of serotype-specific pneumococcal data lies in active disease surveillance. This is also helpful to address whether serotype replacement reflects serotypes that are more invasive or whether serotypes in a specific location are equally more invasive than in other locations. Finally, the last aim of this thesis is to estimate the epidemiological and economic impact of increas- ing serotype coverage in PCVs using a dynamic transmission model. Together, the results highlight that though there are key parameter uncertainties that merit further exploration, divergence in serotype replacement and inconsistencies in invasiveness on a country-level may make a universal PCV suboptimal.Open Acces

    Moduli Stabilisation and the Statistics of Low-Energy Physics in the String Landscape

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    In this thesis we present a detailed analysis of the statistical properties of the type IIB flux landscape of string theory. We focus primarily on models constructed via the Large Volume Scenario (LVS) and KKLT and study the distribution of various phenomenologically relevant quantities. First, we compare our considerations with previous results and point out the importance of Kähler moduli stabilisation, which has been neglected in this context so far. We perform different moduli stabilisation procedures and compare the resulting distributions. To this end, we derive the expressions for the gravitino mass, various quantities related to axion physics and other phenomenologically interesting quantities in terms of the fundamental flux dependent quantities gsg_s, W0W_0 and n\mathfrak{n}, the parameter which specifies the nature of the non-perturbative effects. Exploiting our knowledge of the distribution of these fundamental parameters, we can derive a distribution for all the quantities we are interested in. For models that are stabilised via LVS we find a logarithmic distribution, whereas for KKLT and perturbatively stabilised models we find a power-law distribution. We continue by investigating the statistical significance of a newly found class of KKLT vacua and present a search algorithm for such constructions. We conclude by presenting an application of our findings. Given the mild preference for higher scale supersymmetry breaking, we present a model of the early universe, which allows for additional periods of early matter domination and ultimately leads to rather sharp predictions for the dark matter mass in this model. We find the dark matter mass to be in the very heavy range mχ10101011 GeVm_{\chi}\sim 10^{10}-10^{11}\text{ GeV}

    Increased lifetime of Organic Photovoltaics (OPVs) and the impact of degradation, efficiency and costs in the LCOE of Emerging PVs

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    Emerging photovoltaic (PV) technologies such as organic photovoltaics (OPVs) and perovskites (PVKs) have the potential to disrupt the PV market due to their ease of fabrication (compatible with cheap roll-to-roll processing) and installation, as well as their significant efficiency improvements in recent years. However, rapid degradation is still an issue present in many emerging PVs, which must be addressed to enable their commercialisation. This thesis shows an OPV lifetime enhancing technique by adding the insulating polymer PMMA to the active layer, and a novel model for quantifying the impact of degradation (alongside efficiency and cost) upon levelized cost of energy (LCOE) in real world emerging PV installations. The effect of PMMA morphology on the success of a ternary strategy was investigated, leading to device design guidelines. It was found that either increasing the weight percent (wt%) or molecular weight (MW) of PMMA resulted in an increase in the volume of PMMA-rich islands, which provided the OPV protection against water and oxygen ingress. It was also found that adding PMMA can be effective in enhancing the lifetime of different active material combinations, although not to the same extent, and that processing additives can have a negative impact in the devices lifetime. A novel model was developed taking into account realistic degradation profile sourced from a literature review of state-of-the-art OPV and PVK devices. It was found that optimal strategies to improve LCOE depend on the present characteristics of a device, and that panels with a good balance of efficiency and degradation were better than panels with higher efficiency but higher degradation as well. Further, it was found that low-cost locations were more favoured from reductions in the degradation rate and module cost, whilst high-cost locations were more benefited from improvements in initial efficiency, lower discount rates and reductions in install costs

    Interference mitigation in LiFi networks

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    Due to the increasing demand for wireless data, the radio frequency (RF) spectrum has become a very limited resource. Alternative approaches are under investigation to support the future growth in data traffic and next-generation high-speed wireless communication systems. Techniques such as massive multiple-input multiple-output (MIMO), millimeter wave (mmWave) communications and light-fidelity (LiFi) are being explored. Among these technologies, LiFi is a novel bi-directional, high-speed and fully networked wireless communication technology. However, inter-cell interference (ICI) can significantly restrict the system performance of LiFi attocell networks. This thesis focuses on interference mitigation in LiFi attocell networks. The angle diversity receiver (ADR) is one solution to address the issue of ICI as well as frequency reuse in LiFi attocell networks. With the property of high concentration gain and narrow field of view (FOV), the ADR is very beneficial for interference mitigation. However, the optimum structure of the ADR has not been investigated. This motivates us to propose the optimum structures for the ADRs in order to fully exploit the performance gain. The impact of random device orientation and diffuse link signal propagation are taken into consideration. The performance comparison between the select best combining (SBC) and maximum ratio combining (MRC) is carried out under different noise levels. In addition, the double source (DS) system, where each LiFi access point (AP) consists of two sources transmitting the same information signals but with opposite polarity, is proven to outperform the single source (SS) system under certain conditions. Then, to overcome issues around ICI, random device orientation and link blockage, hybrid LiFi/WiFi networks (HLWNs) are considered. In this thesis, dynamic load balancing (LB) considering handover in HLWNs is studied. The orientation-based random waypoint (ORWP) mobility model is considered to provide a more realistic framework to evaluate the performance of HLWNs. Based on the low-pass filtering effect of the LiFi channel, we firstly propose an orthogonal frequency division multiple access (OFDMA)-based resource allocation (RA) method in LiFi systems. Also, an enhanced evolutionary game theory (EGT)-based LB scheme with handover in HLWNs is proposed. Finally, due to the characteristic of high directivity and narrow beams, a vertical-cavity surface-emitting laser (VCSEL) array transmission system has been proposed to mitigate ICI. In order to support mobile users, two beam activation methods are proposed. The beam activation based on the corner-cube retroreflector (CCR) can achieve low power consumption and almost-zero delay, allowing real-time beam activation for high-speed users. The mechanism based on the omnidirectional transmitter (ODTx) is suitable for low-speed users and very robust to random orientation

    A Molecular Approach to the Diagnosis, Assessment, Monitoring and Treatment of Pulmonary Non-Tuberculous Mycobacterial Disease

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    Introduction: Non-Tuberculous Mycobacteria (NTM) can cause disease of the lungs and sinuses, lymph nodes, joints and central nervous system as well as disseminated infections in immunocompromised individuals. Efforts to tackle infections in NTM are hampered by a lack of reliable biomarkers for diagnosis, assessment of disease activity, and prognostication. Aims: The broad aims of this thesis are: 1. to develop molecular assays capable of quantifying the 6 most common pathogenic mycobacteria (M. abscessus, M. avium, M. intracellulare, M. malmoense, M. kansasii, M. xenopi) and calculate comparative sensitivities and specificities for each assay. 2. to assess patients’ clinical course over 12 – 18 months by performing the developed molecular assays against DNA extracted from sputum from patients with NTM infection. 3. to assess dynamic bacterial changes of the lung microbiome in patients on treatment for NTM disease and those who are treatment na ve. Methods: DNA was extracted from a total of 410 sputum samples obtained from 38 patients who were either: • commencing treatment for either M. abscessus or Mycobacterium avium complex. • considered colonised with M. abscessus or Mycobacterium avium complex (i.e. cultured NTM but were not deemed to have infection as they did not meet ATS or BTS criteria for disease). • Diagnosed with cystic fibrosis (CF) or non-CF bronchiectasis but had never cultured NTM. For the development of quantitative molecular assays, NTM hsp65 gene sequences were aligned and interrogated for areas of variability. These variable regions enabled the creation of species specific probes. In vitro sensitivity and specificity for each probe was determined by testing each probe against a panel of plasmids containing hsp65 gene inserts from different NTM species. Quantification accuracy was determined by using each assay against a mock community containing serial dilutions of target DNA. Each sample was tested with the probes targeting: M. abscessus, M. avium and M. intracellulare producing a longitudinal assessment of NTM copy number during each patient’s clinical course. In addition, a total of 64 samples from 16 patients underwent 16S rRNA gene sequencing to characterise longitudinal changes in the microbiome of both NTM disease and controls. Results: In vitro sensitivity for the custom assays were 100% and specificity ranged from 91.6% to 100%. In terms of quantification accuracy, there was no significant difference between the measured results of each assay and the expected values when performed in singleplex. The assays were able to accurately determine NTM copy number to a theoretical limit of 10 copies/μl. When used against samples derived from human sputum and using culture results as a gold standard, the sensitivity of the assay for M. abscessus was found to be 0.87 and 0.86 for MAC. The specificity of the assay for M. abscessus was 0.95 and 0.62 for MAC. The negative predictive value of the assay for M. abscessus was 0.98 and 0.95 for MAC. This resulted in an AUC of 0.92 for M. abscessus and 0.74 for MAC. Longitudinal analysis of the lung microbiome using 16SrRNA gene sequencing showed that bacterial burden initially decreases after initiation of antibiotic therapy but begins to return to normal levels over several months of antibiotic therapy. This effect is mirrored by changes in alpha diversity. The decrease in bacterial burden and loss of alpha diversity was found to be secondary to significant changes in specific genera such as Veillonella and Streptococcus. The abundance of other Proteobacteria such as Pseudomonas remain relatively constant. Conclusion: The molecular assay has shown high in vitro sensitivity and specificity for the detection and accurate quantification of the 6 most commonly pathogenic NTM species. The assays successfully identified NTM DNA from human sputum samples. A notable association between NTM copy number and the cessation of one or more antibiotics existed (i.e. when one antibiotic was stopped because of patient intolerance, NTM copy number increased, often having been unrecordable prior to this). The qPCR assays developed in this thesis provide an affordable, real time and rapid measurement of NTM burden allowing clinicians to act on problematic results sooner than currently possible. There was no significant difference between the microbiome in bronchiectasis and cystic fibrosis nor was there a significant difference between the microbiome in patients requiring treatment for NTM and those who did not. Patients receiving treatment experienced an initial decrease in bacterial burden over the first weeks of treatment followed by a gradual increase towards baseline over the next weeks to months. This change was mirrored in measures of alpha diversity. Changes in abundance and diversity were accounted for by decreases in specific bacteria whilst the abundance of other bacteria increased, occupying the microbial niche created. These bacteria (for example Pseudomonas spp) are often associated with morbidity.Open Acces

    Towards a non-equilibrium thermodynamic theory of ecosystem assembly and development

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    Non-equilibrium thermodynamics has had a significant historic influence on the development of theoretical ecology, even informing the very concept of an ecosystem. Much of this influence has manifested as proposed extremal principles. These principles hold that systems will tend to maximise certain thermodynamic quantities, subject to the other constraints they operate under. A particularly notable extremal principle is the maximum entropy production principle (MaxEPP); that systems maximise their rate of entropy production. However, these principles are not robustly based in physical theory, and suffer from treating complex ecosystems in an extremely coarse manner. To address this gap, this thesis derives a limited but physically justified extremal principle, as well as carrying out a detailed investigation of the impact of non-equilibrium thermodynamic constraints on the assembly of microbial communities. The extremal principle we obtain pertains to the switching between states in simple bistable systems, with switching paths that generate more entropy being favoured. Our detailed investigation into microbial communities involved developing a novel thermodynamic microbial community model, using which we found the rate of ecosystem development to be set by the availability of free-energy. Further investigation was carried out using this model, demonstrating the way that trade-offs emerging from fundamental thermodynamic constraints impact the dynamics of assembling microbial communities. Taken together our results demonstrate that theory can be developed from non-equilibrium thermodynamics, that is both ecologically relevant and physically well grounded. We find that broad extremal principles are unlikely to be obtained, absent significant advances in the field of stochastic thermodynamics, limiting their applicability to ecology. However, we find that detailed consideration of the non-equilibrium thermodynamic mechanisms that impact microbial communities can broaden our understanding of their assembly and functioning.Open Acces
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