820 research outputs found
Analyzing and clustering neural data
This thesis aims to analyze neural data in an overall effort by the Charles Stark
Draper Laboratory to determine an underlying pattern in brain activity in healthy
individuals versus patients with a brain degenerative disorder. The neural data comes from ECoG (electrocorticography) applied to either humans or primates. Each ECoG array has electrodes that measure voltage variations which neuroscientists claim correlates to neurons transmitting signals to one another. ECoG differs from the less invasive technique of EEG (electroencephalography) in that EEG electrodes are placed above a patients scalp while ECoG involves drilling small holes in the skull to allow electrodes to be closer to the brain. Because of this ECoG boasts an exceptionally high signal-to-noise ratio and less susceptibility to artifacts than EEG [6]. While wearing the ECoG caps, the patients are asked to perform a range of different tasks.
The tasks performed by patients are partitioned into different levels of mental stress
i.e. how much concentration is presumably required. The specific dataset used in
this thesis is derived from cognitive behavior experiments performed on primates at
MGH (Massachusetts General Hospital).
The content of this thesis can be thought of as a pipelined process. First the
data is collected from the ECoG electrodes, then the data is pre-processed via signal processing techniques and finally the data is clustered via unsupervised learning techniques. For both the pre-processing and the clustering steps, different techniques are applied and then compared against one another. The focus of this thesis is to evaluate clustering techniques when applied to neural data.
For the pre-processing step, two types of bandpass filters, a Butterworth Filter
and a Chebyshev Filter were applied. For the clustering step three techniques were
applied to the data, K-means Clustering, Spectral Clustering and Self-Tuning Spectral Clustering. We conclude that for pre-processing the results from both filters are very similar and thus either filter is sufficient. For clustering we conclude that K- means has the lowest amount of overlap between clusters. K-means is also the most time-efficient of the three techniques and is thus the ideal choice for this application.2016-10-27T00:00:00
Bayesian Structure Learning for Markov Random Fields with a Spike and Slab Prior
In recent years a number of methods have been developed for automatically
learning the (sparse) connectivity structure of Markov Random Fields. These
methods are mostly based on L1-regularized optimization which has a number of
disadvantages such as the inability to assess model uncertainty and expensive
cross-validation to find the optimal regularization parameter. Moreover, the
model's predictive performance may degrade dramatically with a suboptimal value
of the regularization parameter (which is sometimes desirable to induce
sparseness). We propose a fully Bayesian approach based on a "spike and slab"
prior (similar to L0 regularization) that does not suffer from these
shortcomings. We develop an approximate MCMC method combining Langevin dynamics
and reversible jump MCMC to conduct inference in this model. Experiments show
that the proposed model learns a good combination of the structure and
parameter values without the need for separate hyper-parameter tuning.
Moreover, the model's predictive performance is much more robust than L1-based
methods with hyper-parameter settings that induce highly sparse model
structures.Comment: Accepted in the Conference on Uncertainty in Artificial Intelligence
(UAI), 201
A hierarchical anti-Hebbian network model for the formation of spatial cells in three-dimensional space.
Three-dimensional (3D) spatial cells in the mammalian hippocampal formation are believed to support the existence of 3D cognitive maps. Modeling studies are crucial to comprehend the neural principles governing the formation of these maps, yet to date very few have addressed this topic in 3D space. Here we present a hierarchical network model for the formation of 3D spatial cells using anti-Hebbian network. Built on empirical data, the model accounts for the natural emergence of 3D place, border, and grid cells, as well as a new type of previously undescribed spatial cell type which we call plane cells. It further explains the plausible reason behind the place and grid-cell anisotropic coding that has been observed in rodents and the potential discrepancy with the predicted periodic coding during 3D volumetric navigation. Lastly, it provides evidence for the importance of unsupervised learning rules in guiding the formation of higher-dimensional cognitive maps
A Model of the Ventral Visual System Based on Temporal Stability and Local Memory
The cerebral cortex is a remarkably homogeneous structure suggesting a rather generic computational machinery. Indeed, under a variety of conditions, functions attributed to specialized areas can be supported by other regions. However, a host of studies have laid out an ever more detailed map of functional cortical areas. This leaves us with the puzzle of whether different cortical areas are intrinsically specialized, or whether they differ mostly by their position in the processing hierarchy and their inputs but apply the same computational principles. Here we show that the computational principle of optimal stability of sensory representations combined with local memory gives rise to a hierarchy of processing stages resembling the ventral visual pathway when it is exposed to continuous natural stimuli. Early processing stages show receptive fields similar to those observed in the primary visual cortex. Subsequent stages are selective for increasingly complex configurations of local features, as observed in higher visual areas. The last stage of the model displays place fields as observed in entorhinal cortex and hippocampus. The results suggest that functionally heterogeneous cortical areas can be generated by only a few computational principles and highlight the importance of the variability of the input signals in forming functional specialization
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