15,002 research outputs found
Low-Rank Matrices on Graphs: Generalized Recovery & Applications
Many real world datasets subsume a linear or non-linear low-rank structure in
a very low-dimensional space. Unfortunately, one often has very little or no
information about the geometry of the space, resulting in a highly
under-determined recovery problem. Under certain circumstances,
state-of-the-art algorithms provide an exact recovery for linear low-rank
structures but at the expense of highly inscalable algorithms which use nuclear
norm. However, the case of non-linear structures remains unresolved. We revisit
the problem of low-rank recovery from a totally different perspective,
involving graphs which encode pairwise similarity between the data samples and
features. Surprisingly, our analysis confirms that it is possible to recover
many approximate linear and non-linear low-rank structures with recovery
guarantees with a set of highly scalable and efficient algorithms. We call such
data matrices as \textit{Low-Rank matrices on graphs} and show that many real
world datasets satisfy this assumption approximately due to underlying
stationarity. Our detailed theoretical and experimental analysis unveils the
power of the simple, yet very novel recovery framework \textit{Fast Robust PCA
on Graphs
Optimal Data Collection For Informative Rankings Expose Well-Connected Graphs
Given a graph where vertices represent alternatives and arcs represent
pairwise comparison data, the statistical ranking problem is to find a
potential function, defined on the vertices, such that the gradient of the
potential function agrees with the pairwise comparisons. Our goal in this paper
is to develop a method for collecting data for which the least squares
estimator for the ranking problem has maximal Fisher information. Our approach,
based on experimental design, is to view data collection as a bi-level
optimization problem where the inner problem is the ranking problem and the
outer problem is to identify data which maximizes the informativeness of the
ranking. Under certain assumptions, the data collection problem decouples,
reducing to a problem of finding multigraphs with large algebraic connectivity.
This reduction of the data collection problem to graph-theoretic questions is
one of the primary contributions of this work. As an application, we study the
Yahoo! Movie user rating dataset and demonstrate that the addition of a small
number of well-chosen pairwise comparisons can significantly increase the
Fisher informativeness of the ranking. As another application, we study the
2011-12 NCAA football schedule and propose schedules with the same number of
games which are significantly more informative. Using spectral clustering
methods to identify highly-connected communities within the division, we argue
that the NCAA could improve its notoriously poor rankings by simply scheduling
more out-of-conference games.Comment: 31 pages, 10 figures, 3 table
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Neural reactivations during sleep determine network credit assignment.
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem. Using neuroprosthetic learning, in which we could control the causal relationship between neurons and behavior, we found that sleep-dependent processing was required for credit assignment and the establishment of task-related functional connectivity reflecting the casual neuron-behavior relationship. Notably, we observed a strong link between the microstructure of sleep reactivations and credit assignment, with downscaling of non-causal activity. Decoupling of spiking to slow oscillations using optogenetic methods eliminated rescaling. Thus, our results suggest that coordinated firing during sleep is essential for establishing sparse activation patterns that reflect the causal neuron-behavior relationship
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterising molecular receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its neighbouring glomeruli. We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbours. Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the dOB. Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.Peer reviewe
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