From Micro to Nano Biphasic Calciumphosphate/Poly-Dl-Lactide-Co- Glycolide Composite Biomaterials for Hard Tissue Reconstruction

Poster presented at the Pittcon 2007 - Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, February 25 – March 2, 2007

Анализ органических загрязнителей воды методами газовой хроматографии с различными видами детектирования

Повышение требований к качеству питьевой воды определяет необходимость разработки новых методов и методик анализа, позволяющих надежно определять качественный и количественный состав присутствующих в воде техногенных и природных соединений. Широкие перспективы связаны в этом плане с хроматографией с использованием высокоэффективных капиллярных колонок и универсальных селективных детекторов или их комбинаций В обзоре обсуждаются достижений возможностей газовой хроматографии с различным детектированием при анализе воды за последние годы и перспективы атомно-эмиссионного детектирования в этой области

Conductivity in Jurkat cell suspension after ultrashort electric pulsing

Ultrashort electric pulses applied to similar cell lines such as Jurkat and HL-60 cells can produce markedly different results , which have been documented extensively over the last few years. We now report changes in electrical conductivity of Jurkat cells subjected to traditional electroporation pulses (50 ms pulse length) and ultrashort pulses (10 ns pulse length) using time domain dielectric spectroscopy (TDS). A single 10 ns, 150 kV/cm pulse did not noticeably alter suspension conductivity while a 50 ms, 2.12 kV/cm pulse with the same energy caused an appreciable conductivity rise. These results support the hypothesis that electroporation pulses primarily interact with the cell membrane and cause conductivity rises due to ion transport from the cell to the external media, while pulses with nanosecond duration primarily interact with the membranes of intracellular organelles. However, multiple ultrashort pulses have a cumulative effect on the plasma membrane, with five pulses causing a gradual rise in conductivity up to ten minutes post-pulsing

К вопросу расширения возможностей аналитического оборудования

Рассмотрены возможности современной материально-технической аналитической базы для обеспечения надлежащего уровня качества лекарственных средств и биологически активных соединений. Исследование проводили посредством контент-анализа литературных данных с элементами структурного анализа. Объектом служили данные о современном аналитическом оборудовании и возможностях его использования в анализе лекарственных средств и биологически активных соединени

General Information

General Informatio

Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets

The density, porosity, breaking force, viscoelastic properties, and the presence or absence of any structural defects or irregularities are important physical-mechanical quality attributes of popular solid dosage forms like tablets. The irregularities associated with these attributes may influence the drug product functionality. Thus, an accurate and efficient characterization of these properties is critical for successful development and manufacturing of a robust tablets. These properties are mainly analyzed and monitored with traditional pharmacopeial and non-pharmacopeial methods. Such methods are associated with several challenges such as lack of spatial resolution, efficiency, or sample-sparing attributes. Recent advances in technology, design, instrumentation, and software have led to the emergence of newer techniques for non-invasive characterization of physical-mechanical properties of tablets. These techniques include near infrared spectroscopy, Raman spectroscopy, X-ray microtomography, nuclear magnetic resonance (NMR) imaging, terahertz pulsed imaging, laser-induced breakdown spectroscopy, and various acoustic- and thermal-based techniques. Such state-of-the-art techniques are currently applied at various stages of development and manufacturing of tablets at industrial scale. Each technique has specific advantages or challenges with respect to operational efficiency and cost, compared to traditional analytical methods. Currently, most of these techniques are used as secondary analytical tools to support the traditional methods in characterizing or monitoring tablet quality attributes. Therefore, further development in the instrumentation and software, and studies on the applications are necessary for their adoption in routine analysis and monitoring of tablet physical-mechanical properties