1,093 research outputs found
Spectral Graph Convolutions for Population-based Disease Prediction
Exploiting the wealth of imaging and non-imaging information for disease
prediction tasks requires models capable of representing, at the same time,
individual features as well as data associations between subjects from
potentially large populations. Graphs provide a natural framework for such
tasks, yet previous graph-based approaches focus on pairwise similarities
without modelling the subjects' individual characteristics and features. On the
other hand, relying solely on subject-specific imaging feature vectors fails to
model the interaction and similarity between subjects, which can reduce
performance. In this paper, we introduce the novel concept of Graph
Convolutional Networks (GCN) for brain analysis in populations, combining
imaging and non-imaging data. We represent populations as a sparse graph where
its vertices are associated with image-based feature vectors and the edges
encode phenotypic information. This structure was used to train a GCN model on
partially labelled graphs, aiming to infer the classes of unlabelled nodes from
the node features and pairwise associations between subjects. We demonstrate
the potential of the method on the challenging ADNI and ABIDE databases, as a
proof of concept of the benefit from integrating contextual information in
classification tasks. This has a clear impact on the quality of the
predictions, leading to 69.5% accuracy for ABIDE (outperforming the current
state of the art of 66.8%) and 77% for ADNI for prediction of MCI conversion,
significantly outperforming standard linear classifiers where only individual
features are considered.Comment: International Conference on Medical Image Computing and
Computer-Assisted Interventions (MICCAI) 201
Multi-GCN: Graph Convolutional Networks for Multi-View Networks, with Applications to Global Poverty
With the rapid expansion of mobile phone networks in developing countries,
large-scale graph machine learning has gained sudden relevance in the study of
global poverty. Recent applications range from humanitarian response and
poverty estimation to urban planning and epidemic containment. Yet the vast
majority of computational tools and algorithms used in these applications do
not account for the multi-view nature of social networks: people are related in
myriad ways, but most graph learning models treat relations as binary. In this
paper, we develop a graph-based convolutional network for learning on
multi-view networks. We show that this method outperforms state-of-the-art
semi-supervised learning algorithms on three different prediction tasks using
mobile phone datasets from three different developing countries. We also show
that, while designed specifically for use in poverty research, the algorithm
also outperforms existing benchmarks on a broader set of learning tasks on
multi-view networks, including node labelling in citation networks
Edge-variational Graph Convolutional Networks for Uncertainty-aware Disease Prediction
There is a rising need for computational models that can complementarily
leverage data of different modalities while investigating associations between
subjects for population-based disease analysis. Despite the success of
convolutional neural networks in representation learning for imaging data, it
is still a very challenging task. In this paper, we propose a generalizable
framework that can automatically integrate imaging data with non-imaging data
in populations for uncertainty-aware disease prediction. At its core is a
learnable adaptive population graph with variational edges, which we
mathematically prove that it is optimizable in conjunction with graph
convolutional neural networks. To estimate the predictive uncertainty related
to the graph topology, we propose the novel concept of Monte-Carlo edge
dropout. Experimental results on four databases show that our method can
consistently and significantly improve the diagnostic accuracy for Autism
spectrum disorder, Alzheimer's disease, and ocular diseases, indicating its
generalizability in leveraging multimodal data for computer-aided diagnosis.Comment: Accepted to MICCAI 202
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