Supporting the clinical trial recruitment process through the grid

Patient recruitment for clinical trials and studies is a large-scale task. To test a given drug for example, it is desirable that as large a pool of suitable candidates is used as possible to support reliable assessment of often moderate effects of the drugs. To make such a recruitment campaign successful, it is necessary to efficiently target the petitioning of these potential subjects. Because of the necessarily large numbers involved in such campaigns, this is a problem that naturally lends itself to the paradigm of Grid technology. However the accumulation and linkage of data sets across clinical domain boundaries poses challenges due to the sensitivity of the data involved that are atypical of other Grid domains. This includes handling the privacy and integrity of data, and importantly the process by which data can be collected and used, and ensuring for example that patient involvement and consent is dealt with appropriately throughout the clinical trials process. This paper describes a Grid infrastructure developed as part of the MRC funded VOTES project (Virtual Organisations for Trials and Epidemiological Studies) at the National e-Science Centre in Glasgow that supports these processes and the different security requirements specific to this domain

Framework Programmable Platform for the advanced software development workstation: Framework processor design document

The design of the Framework Processor (FP) component of the Framework Programmable Software Development Platform (FFP) is described. The FFP is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software development environment. Guided by the model, this Framework Processor will take advantage of an integrated operating environment to provide automated support for the management and control of the software development process so that costly mistakes during the development phase can be eliminated

Experiences in teaching grid computing to advanced level students

The development of teaching materials for future software engineers is critical to the long term success of the grid. At present however there is considerable turmoil in the grid community both within the standards and the technology base underpinning these standards. In this context, it is especially challenging to develop teaching materials that have some sort of lifetime beyond the next wave of grid middleware and standards. In addition, the current way in which grid security is supported and delivered has two key problems. Firstly in the case of the UK e-Science community, scalability issues arise from a central certificate authority. Secondly, the current security mechanisms used by the grid community are not line grained enough. In this paper we outline how these issues are being addressed through the development of a grid computing module supported by an advanced authorisation infrastructure at the University of Glasgow

The PERMIS X.509 Based Privilege Management Infrastructure

This document describes the PERMIS X.509 Based Privilege Management Infrastructure, which is a trust management system as described in RFC 2704 [2]. The PERMIS Infrastructure is compared with the AAA Authorisation Framework described in RFC 2904 [4], and is shown to be compatible with it