2,278 research outputs found
Explainable cardiac pathology classification on cine MRI with motion characterization by semi-supervised learning of apparent flow
We propose a method to classify cardiac pathology based on a novel approach
to extract image derived features to characterize the shape and motion of the
heart. An original semi-supervised learning procedure, which makes efficient
use of a large amount of non-segmented images and a small amount of images
segmented manually by experts, is developed to generate pixel-wise apparent
flow between two time points of a 2D+t cine MRI image sequence. Combining the
apparent flow maps and cardiac segmentation masks, we obtain a local apparent
flow corresponding to the 2D motion of myocardium and ventricular cavities.
This leads to the generation of time series of the radius and thickness of
myocardial segments to represent cardiac motion. These time series of motion
features are reliable and explainable characteristics of pathological cardiac
motion. Furthermore, they are combined with shape-related features to classify
cardiac pathologies. Using only nine feature values as input, we propose an
explainable, simple and flexible model for pathology classification. On ACDC
training set and testing set, the model achieves 95% and 94% respectively as
classification accuracy. Its performance is hence comparable to that of the
state-of-the-art. Comparison with various other models is performed to outline
some advantages of our model
Single- and Multiple-Shell Uniform Sampling Schemes for Diffusion MRI Using Spherical Codes
In diffusion MRI (dMRI), a good sampling scheme is important for efficient
acquisition and robust reconstruction. Diffusion weighted signal is normally
acquired on single or multiple shells in q-space. Signal samples are typically
distributed uniformly on different shells to make them invariant to the
orientation of structures within tissue, or the laboratory coordinate frame.
The Electrostatic Energy Minimization (EEM) method, originally proposed for
single shell sampling scheme in dMRI, was recently generalized to multi-shell
schemes, called Generalized EEM (GEEM). GEEM has been successfully used in the
Human Connectome Project (HCP). However, EEM does not directly address the goal
of optimal sampling, i.e., achieving large angular separation between sampling
points. In this paper, we propose a more natural formulation, called Spherical
Code (SC), to directly maximize the minimal angle between different samples in
single or multiple shells. We consider not only continuous problems to design
single or multiple shell sampling schemes, but also discrete problems to
uniformly extract sub-sampled schemes from an existing single or multiple shell
scheme, and to order samples in an existing scheme. We propose five algorithms
to solve the above problems, including an incremental SC (ISC), a sophisticated
greedy algorithm called Iterative Maximum Overlap Construction (IMOC), an 1-Opt
greedy method, a Mixed Integer Linear Programming (MILP) method, and a
Constrained Non-Linear Optimization (CNLO) method. To our knowledge, this is
the first work to use the SC formulation for single or multiple shell sampling
schemes in dMRI. Experimental results indicate that SC methods obtain larger
angular separation and better rotational invariance than the state-of-the-art
EEM and GEEM. The related codes and a tutorial have been released in DMRITool.Comment: Accepted by IEEE transactions on Medical Imaging. Codes have been
released in dmritool
https://diffusionmritool.github.io/tutorial_qspacesampling.htm
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