2,225 research outputs found
Multidisciplinary perspectives on Artificial Intelligence and the law
This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio
Flow characterization of compressible particulate biomass materials
Biomass materials like trees and crops can be converted to biochemical products and have been considered as one of the most promising alternatives for energy and fuels due to their abundance and easy access. However, the commercialization of bioenergy has been significantly constrained by severe issues during the handling of particulate biomass materials, manifested as unstable flow and jamming in handling equipment such as hoppers, feeders, or conveyors. Solving these issues centers on the mechanistic understanding of the flowability of milled biomass materials and their rheological and constitutive behaviors in various industrial equipment.
This thesis investigates the flow behavior of milled woody biomass across multiple scales and flow regimes. The study experimentally quantifies the mechanical and rheological properties of particulate biomass at particle, meso, and industrial scales, complemented by FEM simulations of biomass flow through hoppers and inclined planes at meso and industrial scales. The jamming physics of woody particles in wedge-shaped hoppers is analyzed in consideration of hopper geometry, particle density, packing, and surcharge. With these results, parameters governing the arching, mass flow, and funnel flow of milled biomass through industry hoppers are identified. These findings enable the design and optimization of industry hoppers for the efficient handling of milled woody biomass. In addition, the constitutive model characterizing the flow of milled woody biomass at both quasi-static and dynamic flow regimes is formulated and validated against laboratory data. In the end, the impacts of moisture content on the mechanical and flow behavior of milled woody biomass are evaluated. This study promotes the fundamental understanding of the flow physics of milled biomass materials across various scales, fosters high-fidelity numerical prediction models of the constitutive responses of compressible particulate biomass, and enables the development of the next-generation high-efficiency biomass handling equipment to reduce the cost and increase the safety of feedstock processing.Ph.D
Kinetic energy fluctuation-driven locomotor transitions on potential energy landscapes of beam obstacle traversal and self-righting
Despite contending with constraints imposed by the environment, morphology,
and physiology, animals move well by physically interactingwith the environment
to use and transition between modes such as running, climbing, and
self-righting. By contrast, robots struggle to do so in real world.
Understanding the principles of how locomotor transitions emerge from
constrained physical interaction is necessary for robots to move robustly using
similar strategies. Recent studies discovered that discoid cockroaches use and
transition between diverse locomotor modes to traverse beams and self-right on
ground. For both systems, animals probabilistically transitioned between modes
via multiple pathways, while its self-propulsion created kinetic energy
fluctuation. Here, we seek mechanistic explanations for these observations by
adopting a physics-based approach that integrates biological and robotic
studies.
We discovered that animal and robot locomotor transitions during beam
obstacle traversal and ground self-righting are barrier-crossing transitions on
potential energy landscapes. Whereas animals and robot traversed stiff beams by
rolling their body betweenbeam, they pushed across flimsy beams, suggesting a
concept of terradynamic favorability where modes with easier physical
interaction are more likely to occur. Robotic beam traversal revealed that,
system state either remains in a favorable mode or transitions to one when
energy fluctuation is comparable to the transition barrier. Robotic
self-righting transitions occurred similarly and revealed that changing system
parameters lowers barriers over which comparable fluctuation can induce
transitions. Thetransitionsof animalsin both systems mostly occurred similarly,
but sensory feedback may facilitate its beam traversal. Finally, we developed a
method to measure animal movement across large spatiotemporal scales in a
terrain treadmill.Comment: arXiv admin note: substantial text overlap with arXiv:2006.1271
Detecting anomalies from liquid transfer videos in automated laboratory setting
In this work, we address the problem of detecting anomalies in a certain laboratory automation setting. At first, we collect video images of liquid transfer in automated laboratory experiments. We mimic the real-world challenges of developing an anomaly detection model by considering two points. First, the size of the collected dataset is set to be relatively small compared to large-scale video datasets. Second, the dataset has a class imbalance problem where the majority of the collected videos are from abnormal events. Consequently, the existing learning-based video anomaly detection methods do not perform well. To this end, we develop a practical human-engineered feature extraction method to detect anomalies from the liquid transfer video images. Our simple yet effective method outperforms state-of-the-art anomaly detection methods with a notable margin. In particular, the proposed method provides 19% and 76% average improvement in AUC and Equal Error Rate, respectively. Our method also quantifies the anomalies and provides significant benefits for deployment in the real-world experimental setting
Automated identification and behaviour classification for modelling social dynamics in group-housed mice
Mice are often used in biology as exploratory models of human conditions, due to their similar genetics and physiology. Unfortunately, research on behaviour has traditionally been limited to studying individuals in isolated environments and over short periods of time. This can miss critical time-effects, and, since mice are social creatures, bias results.
This work addresses this gap in research by developing tools to analyse the individual behaviour of group-housed mice in the home-cage over several days and with minimal disruption. Using data provided by the Mary Lyon Centre at MRC Harwell we designed an end-to-end system that (a) tracks and identifies mice in a cage, (b) infers their behaviour, and subsequently (c) models the group dynamics as functions of individual activities. In support of the above, we also curated and made available a large dataset of mouse localisation and behaviour classifications (IMADGE), as well as two smaller annotated datasets for training/evaluating the identification (TIDe) and behaviour inference (ABODe) systems. This research constitutes the first of its kind in terms of the scale and challenges addressed. The data source (side-view single-channel video with clutter and no identification markers for mice) presents challenging conditions for analysis, but has the potential to give richer information while using industry standard housing.
A Tracking and Identification module was developed to automatically detect, track and identify the (visually similar) mice in the cluttered home-cage using only single-channel IR video and coarse position from RFID readings. Existing detectors and trackers were combined with a novel Integer Linear Programming formulation to assign anonymous tracks to mouse identities. This utilised a probabilistic weight model of affinity between detections and RFID pickups.
The next task necessitated the implementation of the Activity Labelling module that classifies the behaviour of each mouse, handling occlusion to avoid giving unreliable classifications when the mice cannot be observed. Two key aspects of this were (a) careful feature-selection, and (b) judicious balancing of the errors of the system in line with the repercussions for our setup.
Given these sequences of individual behaviours, we analysed the interaction dynamics between mice in the same cage by collapsing the group behaviour into a sequence of interpretable latent regimes using both static and temporal (Markov) models. Using a permutation matrix, we were able to automatically assign mice to roles in the HMM, fit a global model to a group of cages and analyse abnormalities in data from a different demographic
Unveiling the frontiers of deep learning: innovations shaping diverse domains
Deep learning (DL) enables the development of computer models that are
capable of learning, visualizing, optimizing, refining, and predicting data. In
recent years, DL has been applied in a range of fields, including audio-visual
data processing, agriculture, transportation prediction, natural language,
biomedicine, disaster management, bioinformatics, drug design, genomics, face
recognition, and ecology. To explore the current state of deep learning, it is
necessary to investigate the latest developments and applications of deep
learning in these disciplines. However, the literature is lacking in exploring
the applications of deep learning in all potential sectors. This paper thus
extensively investigates the potential applications of deep learning across all
major fields of study as well as the associated benefits and challenges. As
evidenced in the literature, DL exhibits accuracy in prediction and analysis,
makes it a powerful computational tool, and has the ability to articulate
itself and optimize, making it effective in processing data with no prior
training. Given its independence from training data, deep learning necessitates
massive amounts of data for effective analysis and processing, much like data
volume. To handle the challenge of compiling huge amounts of medical,
scientific, healthcare, and environmental data for use in deep learning, gated
architectures like LSTMs and GRUs can be utilized. For multimodal learning,
shared neurons in the neural network for all activities and specialized neurons
for particular tasks are necessary.Comment: 64 pages, 3 figures, 3 table
AN UNUSUAL SUSPECT IN CYTOKINESIS, DISCOIDIN I, HELPS ASSEMBLE THE CONTRACTILE MACHINERY IN THE CYTOPLASM AND IMPLICATIONS OF THIS SYSTEM IN CANCER
Many biological processes entail the ability of cells to sense and adapt to its physical surroundings. This ability, in turn, requires cells to exert robust cell shape changes. Processes ranging from cytokinesis and migration to more complex events such as multi-cellular development require robust and constant integration of internal and external mechanical cues to exert these physical modifications. To complete such modifications, cells need to integrate internal and external cues through a contractility machinery that includes actin filaments, myosin II (MyoII) motors, crosslinkers, and other scaffolding proteins. These proteins compose a mechanoresponsive system that allows cells to receive as well as respond to chemical and mechanical signals through accumulation to direct cell shape change events. We define this extensive network as the contractile machinery.
Several key proteins of the mechanosensory system preassemble in the cytoplasm, forming mechanoresponsive and non-mechanoresponsive contractility kits (CKs). This network of proteins includes several other proteins, including the Discoidin 1 (Dsc1) proteins. Discoidin 1 belongs to the N-acetylgalactosamine (GalNAc)-binding lectins found in the amoeba Dictyostelium discoideum. How it functions intracellularly in vegetative cells has been elusive.
Here, we find that DscI ensures robust cytokinesis through regulating intracellular components of the contractile machinery. Specifically, DscI is necessary for normal cytokinesis, cortical tension, membrane-cortex connections, and cortical distribution and mechanoresponsiveness of cortexillin I. We also find that absence of DscI weakens the interactions within the CK complex. Furthermore, the activity of DscI inside cell is tightly governed by components of the non-mechanoresponsive CKs, providing a layer of feedback regulation that ensures balance in the contractility system.
Overall, this work re-emphasizes the point that many proteins contribute in multiple diverse ways to the function of the cell, and it is increasingly apparent that proteins may not be described as providing a single function for the cell. Since many important cellular processes are under the regulation of this system, elucidation of the molecular network that drives this system helps provide great insights into normal cell behaviors as well as any diseases that might stem from malfunctioning of the system
Meta-Transformer: A Unified Framework for Multimodal Learning
Multimodal learning aims to build models that can process and relate
information from multiple modalities. Despite years of development in this
field, it still remains challenging to design a unified network for processing
various modalities ( natural language, 2D images, 3D point
clouds, audio, video, time series, tabular data) due to the inherent gaps among
them. In this work, we propose a framework, named Meta-Transformer, that
leverages a encoder to perform multimodal perception without
any paired multimodal training data. In Meta-Transformer, the raw input data
from various modalities are mapped into a shared token space, allowing a
subsequent encoder with frozen parameters to extract high-level semantic
features of the input data. Composed of three main components: a unified data
tokenizer, a modality-shared encoder, and task-specific heads for downstream
tasks, Meta-Transformer is the first framework to perform unified learning
across 12 modalities with unpaired data. Experiments on different benchmarks
reveal that Meta-Transformer can handle a wide range of tasks including
fundamental perception (text, image, point cloud, audio, video), practical
application (X-Ray, infrared, hyperspectral, and IMU), and data mining (graph,
tabular, and time-series). Meta-Transformer indicates a promising future for
developing unified multimodal intelligence with transformers. Code will be
available at https://github.com/invictus717/MetaTransformerComment: Project website: https://kxgong.github.io/meta_transformer
Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics
Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are
often assumed to respond elastically for simplicity; the viscoelastic response is quite
commonly ignored. Extracellular matrix mechanics including the viscoelasticity has turned
out to be a key feature of cellular behavior and the entire shape and function of healthy and
diseased tissues, such as cancer. The interference of cells with their local
microenvironment and the interaction among different cell types relies both on the
mechanical phenotype of each involved element. However, there is still not yet clearly
understood how viscoelasticity alters the functional phenotype of the tumor extracellular
matrix environment. Especially the biophysical technologies are still under ongoing
improvement and further development. In addition, the effect of matrix mechanics in
the progression of cancer is the subject of discussion. Hence, the topic of this review is
especially attractive to collect the existing endeavors to characterize the viscoelastic
features of tumor extracellular matrices and to briefly highlight the present frontiers in
cancer progression and escape of cancers from therapy. Finally, this review article
illustrates the importance of the tumor extracellular matrix mechano-phenotype,
including the phenomenon viscoelasticity in identifying, characterizing, and treating
specific cancer types
Human Activity Recognition and Fall Detection Using Unobtrusive Technologies
As the population ages, health issues like injurious falls demand more attention. Wearable devices can be used to detect falls. However, despite their commercial success, most wearable devices are obtrusive, and patients generally do not like or may forget to wear them. In this thesis, a monitoring system consisting of two 24×32 thermal array sensors and a millimetre-wave (mmWave) radar sensor was developed to unobtrusively detect locations and recognise human activities such as sitting, standing, walking, lying, and falling. Data were collected by observing healthy young volunteers simulate ten different scenarios. The optimal installation position of the sensors was initially unknown. Therefore, the sensors were mounted on a side wall, a corner, and on the ceiling of the experimental room to allow performance comparison between these sensor placements. Every thermal frame was converted into an image and a set of features was manually extracted or convolutional neural networks (CNNs) were used to automatically extract features. Applying a CNN model on the infrared stereo dataset to recognise five activities (falling plus lying on the floor, lying in bed, sitting on chair, sitting in bed, standing plus walking), overall average accuracy and F1-score were 97.6%, and 0.935, respectively. The scores for detecting falling plus lying on the floor from the remaining activities were 97.9%, and 0.945, respectively. When using radar technology, the generated point clouds were converted into an occupancy grid and a CNN model was used to automatically extract features, or a set of features was manually extracted. Applying several classifiers on the manually extracted features to detect falling plus lying on the floor from the remaining activities, Random Forest (RF) classifier achieved the best results in overhead position (an accuracy of 92.2%, a recall of 0.881, a precision of 0.805, and an F1-score of 0.841). Additionally, the CNN model achieved the best results (an accuracy of 92.3%, a recall of 0.891, a precision of 0.801, and an F1-score of 0.844), in overhead position and slightly outperformed the RF method. Data fusion was performed at a feature level, combining both infrared and radar technologies, however the benefit was not significant. The proposed system was cost, processing time, and space efficient. The system with further development can be utilised as a real-time fall detection system in aged care facilities or at homes of older people
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