4,586 research outputs found
A Generative-Discriminative Basis Learning Framework to Predict Clinical Severity from Resting State Functional MRI Data
We propose a matrix factorization technique that decomposes the resting state
fMRI (rs-fMRI) correlation matrices for a patient population into a sparse set
of representative subnetworks, as modeled by rank one outer products. The
subnetworks are combined using patient specific non-negative coefficients;
these coefficients are also used to model, and subsequently predict the
clinical severity of a given patient via a linear regression. Our
generative-discriminative framework is able to exploit the structure of rs-fMRI
correlation matrices to capture group level effects, while simultaneously
accounting for patient variability. We employ ten fold cross validation to
demonstrate the predictive power of our model on a cohort of fifty eight
patients diagnosed with Autism Spectrum Disorder. Our method outperforms
classical semi-supervised frameworks, which perform dimensionality reduction on
the correlation features followed by non-linear regression to predict the
clinical scores
Sparse Multivariate Autoregressive Modeling for Mild Cognitive Impairment Classification
Brain connectivity network derived from functional magnetic resonance imaging (fMRI) is becoming increasingly prevalent in the researches related to cognitive and perceptual processes. The capability to detect causal or effective connectivity is highly desirable for understanding the cooperative nature of brain network, particularly when the ultimate goal is to obtain good performance of control-patient classification with biological meaningful interpretations. Understanding directed functional interactions between brain regions via brain connectivity network is a challenging task. Since many genetic and biomedical networks are intrinsically sparse, incorporating sparsity property into connectivity modeling can make the derived models more biologically plausible. Accordingly, we propose an effective connectivity modeling of resting-state fMRI data based on the multivariate autoregressive (MAR) modeling technique, which is widely used to characterize temporal information of dynamic systems. This MAR modeling technique allows for the identification of effective connectivity using the Granger causality concept and reducing the spurious causality connectivity in assessment of directed functional interaction from fMRI data. A forward orthogonal least squares (OLS) regression algorithm is further used to construct a sparse MAR model. By applying the proposed modeling to mild cognitive impairment (MCI) classification, we identify several most discriminative regions, including middle cingulate gyrus, posterior cingulate gyrus, lingual gyrus and caudate regions, in line with results reported in previous findings. A relatively high classification accuracy of 91.89 % is also achieved, with an increment of 5.4 % compared to the fully-connected, non-directional Pearson-correlation-based functional connectivity approach
Spectral Graph Convolutions for Population-based Disease Prediction
Exploiting the wealth of imaging and non-imaging information for disease
prediction tasks requires models capable of representing, at the same time,
individual features as well as data associations between subjects from
potentially large populations. Graphs provide a natural framework for such
tasks, yet previous graph-based approaches focus on pairwise similarities
without modelling the subjects' individual characteristics and features. On the
other hand, relying solely on subject-specific imaging feature vectors fails to
model the interaction and similarity between subjects, which can reduce
performance. In this paper, we introduce the novel concept of Graph
Convolutional Networks (GCN) for brain analysis in populations, combining
imaging and non-imaging data. We represent populations as a sparse graph where
its vertices are associated with image-based feature vectors and the edges
encode phenotypic information. This structure was used to train a GCN model on
partially labelled graphs, aiming to infer the classes of unlabelled nodes from
the node features and pairwise associations between subjects. We demonstrate
the potential of the method on the challenging ADNI and ABIDE databases, as a
proof of concept of the benefit from integrating contextual information in
classification tasks. This has a clear impact on the quality of the
predictions, leading to 69.5% accuracy for ABIDE (outperforming the current
state of the art of 66.8%) and 77% for ADNI for prediction of MCI conversion,
significantly outperforming standard linear classifiers where only individual
features are considered.Comment: International Conference on Medical Image Computing and
Computer-Assisted Interventions (MICCAI) 201
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