Computational Inverse Problems

Inverse problem typically deal with the identification of unknown quantities from indirect measurements and appear in many areas in technology, medicine, biology, finance, and econometrics. The computational solution of such problems is a very active, interdisciplinary field with close connections to optimization, control theory, differential equations, asymptotic analysis, statistics, and probability. The focus of this workshop was on hybrid methods, model reduction, regularization in Banach spaces, and statistical approaches

A Reversible Jump MCMC Algorithm for Particle Size Inversion in Multiangle Dynamic Light Scattering

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 201

Modified laplace transform and its properties

In this paper we propose a new definition of the modified Laplace transform La(f(t)) for a piece-wise continuous function of exponential order which further reduces to simple Laplace transform for a = e where a a ≠ 1 and a > 0. Also we prove some basic results of this modified Laplace transform and connection with different functions. © 2020, International Scientific Research Publications. All rights reserved

Advanced data analysis for traction force microscopy and data-driven discovery of physical equations

The plummeting cost of collecting and storing data and the increasingly available computational power in the last decade have led to the emergence of new data analysis approaches in various scientific fields. Frequently, the new statistical methodology is employed for analyzing data involving incomplete or unknown information. In this thesis, new statistical approaches are developed for improving the accuracy of traction force microscopy (TFM) and data-driven discovery of physical equations. TFM is a versatile method for the reconstruction of a spatial image of the traction forces exerted by cells on elastic gel substrates. The traction force field is calculated from a linear mechanical model connecting the measured substrate displacements with the sought-for cell-generated stresses in real or Fourier space, which is an inverse and ill-posed problem. This inverse problem is commonly solved making use of regularization methods. Here, we systematically test the performance of new regularization methods and Bayesian inference for quantifying the parameter uncertainty in TFM. We compare two classical schemes, L1- and L2-regularization with three previously untested schemes, namely Elastic Net regularization, Proximal Gradient Lasso, and Proximal Gradient Elastic Net. We find that Elastic Net regularization, which combines L1 and L2 regularization, outperforms all other methods with regard to accuracy of traction reconstruction. Next, we develop two methods, Bayesian L2 regularization and Advanced Bayesian L2 regularization, for automatic, optimal L2 regularization. We further combine the Bayesian L2 regularization with the computational speed of Fast Fourier Transform algorithms to develop a fully automated method for noise reduction and robust, standardized traction-force reconstruction that we call Bayesian Fourier transform traction cytometry (BFTTC). This method is made freely available as a software package with graphical user-interface for intuitive usage. Using synthetic data and experimental data, we show that these Bayesian methods enable robust reconstruction of traction without requiring a difficult selection of regularization parameters specifically for each data set. Next, we employ our methodology developed for the solution of inverse problems for automated, data-driven discovery of ordinary differential equations (ODEs), partial differential equations (PDEs), and stochastic differential equations (SDEs). To find the equations governing a measured time-dependent process, we construct dictionaries of non-linear candidate equations. These candidate equations are evaluated using the measured data. With this approach, one can construct a likelihood function for the candidate equations. Optimization yields a linear, inverse problem which is to be solved under a sparsity constraint. We combine Bayesian compressive sensing using Laplace priors with automated thresholding to develop a new approach, namely automatic threshold sparse Bayesian learning (ATSBL). ATSBL is a robust method to identify ODEs, PDEs, and SDEs involving Gaussian noise, which is also referred to as type I noise. We extensively test the method with synthetic datasets describing physical processes. For SDEs, we combine data-driven inference using ATSBL with a novel entropy-based heuristic for discarding data points with high uncertainty. Finally, we develop an automatic iterative sampling optimization technique akin to Umbrella sampling. Therewith, we demonstrate that data-driven inference of SDEs can be substantially improved through feedback during the inference process if the stochastic process under investigation can be manipulated either experimentally or in simulations

Robust inversion and detection techniques for improved imaging performance

Thesis (Ph.D.)--Boston UniversityIn this thesis we aim to improve the performance of information extraction from imaging systems through three thrusts. First, we develop improved image formation methods for physics-based, complex-valued sensing problems. We propose a regularized inversion method that incorporates prior information about the underlying field into the inversion framework for ultrasound imaging. We use experimental ultrasound data to compute inversion results with the proposed formulation and compare it with conventional inversion techniques to show the robustness of the proposed technique to loss of data. Second, we propose methods that combine inversion and detection in a unified framework to improve imaging performance. This framework is applicable for cases where the underlying field is label-based such that each pixel of the underlying field can only assume values from a discrete, limited set. We consider this unified framework in the context of combinatorial optimization and propose graph-cut based methods that would result in label-based images, thereby eliminating the need for a separate detection step. Finally, we propose a robust method of object detection from microscopic nanoparticle images. In particular, we focus on a portable, low cost interferometric imaging platform and propose robust detection algorithms using tools from computer vision. We model the electromagnetic image formation process and use this model to create an enhanced detection technique. The effectiveness of the proposed technique is demonstrated using manually labeled ground-truth data. In addition, we extend these tools to develop a detection based autofocusing algorithm tailored for the high numerical aperture interferometric microscope

4-D Tomographic Inference: Application to SPECT and MR-driven PET

Emission tomographic imaging is framed in the Bayesian and information theoretic framework. The first part of the thesis is inspired by the new possibilities offered by PET-MR systems, formulating models and algorithms for 4-D tomography and for the integration of information from multiple imaging modalities. The second part of the thesis extends the models described in the first part, focusing on the imaging hardware. Three key aspects for the design of new imaging systems are investigated: criteria and efficient algorithms for the optimisation and real-time adaptation of the parameters of the imaging hardware; learning the characteristics of the imaging hardware; exploiting the rich information provided by depthof- interaction (DOI) and energy resolving devices. The document concludes with the description of the NiftyRec software toolkit, developed to enable 4-D multi-modal tomographic inference

From Dark Matter to the Earth's Deep Interior: There and Back Again

This thesis is a two-way transfer of knowledge between cosmology and seismology, aiming to substantially advance imaging methods and uncertainty quantification in both fields. I develop a method using wavelets to simulate the uncertainty in a set of existing global seismic tomography images to assess the robustness of mantle plume-like structures. Several plumes are identified, including one that is rarely discussed in the seismological literature. I present a new classification of the most likely deep mantle plumes from my automated method, potentially resolving past discrepancies between deep mantle plumes inferred by visual analysis of tomography models and other geophysical data. Following on from this, I create new images of the upper-most mantle and their associated uncertainties using a sparsity-promoting wavelet prior and an advanced probabilistic inversion scheme. These new images exhibit the expected tectonic features such as plate boundaries and continental cratons. Importantly, the uncertainties obtained are physically reasonable and informative, in that they reflect the heterogenous data distribution and also highlight artefacts due to an incomplete forward model. These inversions are a first step towards building a fully probabilistic upper-mantle model in a sparse wavelet basis. I then apply the same advanced probabilistic method to the problem of full-sky cosmological mass-mapping. However, this is severely limited by the computational complexity of high-resolution spherical harmonic transforms. In response to this, I use, for the first time in cosmology, a trans-dimensional algorithm to build galaxy cluster-scale mass-maps. This new approach performs better than the standard mass-mapping method, with the added benefit that uncertainties are naturally recovered. With more accurate mass-maps and uncertainties, this method will be a valuable tool for cosmological inference with the new high-resolution data expected from upcoming galaxy surveys, potentially providing new insights into the interactions of dark matter particles in colliding galaxy cluster systems