Spartan Daily, October 24, 1983

Volume 81, Issue 39https://scholarworks.sjsu.edu/spartandaily/7088/thumbnail.jp

Pooled Energy Budget and Human Life History

Human life history contains a series of paradoxes not easily explained by classical life history theory. While overall reproductive output is higher than in related primates, juvenile growth is slower and age-specific reproductive rates decline faster with age. A simple energetic model would predict that growth and reproductive rates should be positively correlated and that reproductive effort should not decelerate with age. The pattern of negative correlations in humans suggests the presence of trade-offs among peak reproductive rate, childhood growth, and reproductive rate at older ages. To address this puzzle, we propose a synthesis of reproductive ecology and behavioral ecology focused on intra- and inter-somatic energy transfers. This integration includes three concepts: the mother as final common pathway through which energy must pass to result in offspring; a distinction between direct and indirect reproductive effort, proposing the latter as a novel net energy allocation category relative to growth and direct reproductive effort; and a pooled energy budget representing the energetic contributions and withdrawals of all members of a breeding community. Individuals at all reproductive life stages are considered in light of their contributions to the pooled energy budget. This is a preprint of an article accepted for publication in The American Journal of Human Biology © 2009 Peter T. EllisonAnthropologyHuman Evolutionary Biolog

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair

A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.Board of Regents, University of Texas Syste

Micro-RNA family that modulates fibrosis and uses thereof

The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.Board of Regents, University of Texas Syste

Evaluation of services for younger parents at Halton Lodge Children’s Centre

© University of ChesterIn 1999 a report by the Social Exclusion Unit (SEU) identified that the children of younger parents, and indeed younger parents themselves, were more likely to experience poor outcomes. The government’s ten year Teenage Pregnancy Strategy marked a renewed focus on teenage pregnancy as a priority area for intervention. Central to its aims are the reduction of teenage pregnancy rates and; the provision of support which will improve the life chances of teenage parents and their children. Sure Start local programmes are expected to reach certain targets regarding contact with, and registration of, pregnant women in their areas. In acknowledging the ‘apprehensions of teenage parents about taking part in activities with older parents’ (Sure Start Unit, 2005, p.571) the advice for working with teenage parents also highlights the need for centres to adopt a specialised, young person-centred approach to providing services for younger parents. The aim of this commissioned research project was to examine the provision of services for younger parents by Sure Start Jolly Giraffe at Halton Lodge Children’s Centre

Human metabolic adaptations and prolonged expensive neurodevelopment: A review

1.	After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision.
2.	The childhood (pediatric) and the adult human brain takes a very high share of both basal metabolic rate (BMR) (child: 50-70%; adult: ≈20%) and total energy expenditure (TEE) (child: 30-50%; adult: ≈10%).
3.	The pediatric brain for an extended period (≈4-9 years-of-age) consumes roughly 50% more energy than the adult one, and after this, continues during adolescence, at a high but declining rate. Within the brain, childhood cerebral gray matter has an even higher 1.9 to 2.2-fold increased energy consumption. 
4.	This metabolic expensiveness is due to (i) the high cost of synapse activation (74% of brain energy expenditure in humans), combined with (ii), a prolonged period of exuberance in synapse numbers (up to double the number present in adults). Cognitive development during this period associates with volumetric changes in gray matter (expansion and contraction due to metabolic related size alterations in glial cells and capillary vascularization), and in white matter (expansion due to myelination). 
5.	Amongst mammals, anatomically modern humans show an unique pattern in which very slow musculoskeletal body growth is followed by a marked adolescent size/stature spurt. This pattern of growth contrasts with nonhuman primates that have a sustained fast juvenile growth with only a minor period of puberty acceleration. The existence of slow childhood growth in humans has been shown to date back to 160,000 BP. 
6.	Human children physiologically have a limited capacity to protect the brain from plasma glucose fluctuations and other metabolic disruptions. These can arise in adults, during prolonged strenuous exercise when skeletal muscle depletes plasma glucose, and produces other metabolic disruptions upon the brain (hypoxia, hyperthermia, dehydration and hyperammonemia). These are proportional to muscle mass.
7.	Children show specific adaptations to minimize such metabolic disturbances. (i) Due to slow body growth and resulting small body size, they have limited skeletal muscle mass. (ii) They show other adaptations such as an exercise specific preference for free fatty acid metabolism. (iii) While children are generally more active than adolescents and adults, they avoid physically prolonged intense exertion. 
8.	Childhood has a close relationship to high levels of energy provision and metabolic adaptations that support prolonged synaptic neurodevelopment. 
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Micro-RNAS that control myosin expression and myofiber identity

The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.Board of Regents, University of Texas Syste

Review:Herbivory and the power of phytochemical diversity on animal health

Plant secondary compounds (PSCs) were thought to be waste products of plant metabolism when first identified in the mid-1800 s. Since then, many different roles have been recognized for these chemicals. With regard to their function as defense, PSCs can negatively impact different cellular and metabolic processes in the herbivore, causing illness and reductions in feed intake. This penalty on fitness also applies to other trophic levels, like the microorganisms and parasites that infect herbivores and thus, PSCs at certain doses may function as medicines. In turn, herbivores evolved learning mechanisms to cope with the constant variability in their environment and physiological needs. Under this context, foraging can be viewed as the quest for substances in the external environment that provide homeostatic utility to the animal. For instance, herbivores increase preference for PSC-containing feeds that negatively impact infectious agents (i.e., therapeutic self-medication). Given that some classes of PSCs like polyphenols present antioxidant, antiinflammatory, immunomodulatory and prebiotic properties, chronic and sustained consumption of these chemicals results in robust animals that are tolerant to disease (i.e., prophylactic self-medication). Foraging plasticity in terms of the quality and quantity of nutrients ingested in the absence and during sickness may also influence immunocompetence, resistance and resilience to infection, and thus can be interpreted as another form of medication. Finally, self-medicative behaviors can be transmitted through social learning. We suggest that foraging studies will benefit from exploring self-medicative behaviors in chemically diverse plant communities, in particular when considering the vast diversity of PSC structures (more than 200 000) observed in nature. We then lay out a framework for enhancing the medicinal effects of PSCs on grazing herbivores. We propose landscape interventions through the establishment of resource patches or “islands” with a diversity of PSC-containing forages (e.g., legumes, herbs, shrubs) in monotonous rangelands or pasturelands, viewed as a “sea” of low-diversity vegetation devoid of functional biochemicals. Strategies aimed at enhancing the diversity of plant communities lead to heterogeneity in chemical, structural and functional landscape traits that offer options to foragers, and thus allow for balanced diets that maintain and restore health. Beyond animal health, such heterogeneity promotes a broad array of ecosystem services that significantly improve landscape resilience to environmental disturbances.</p

Curtis\u27s botanical magazine.

v.145=ser.4:v.15 (1919) [no.8786-8829