Could Public Restrooms Be an Environment for Bacterial Resistomes?

PMCID: PMC3547874This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

ASAP: A Source Code Authorship Program

Source code authorship attribution is the task of determining who wrote a computer program, based on its source code, usually when the author is either unknown or under dispute. Areas where this can be applied include software forensics, cases of software copyright infringement, and detecting plagiarism. Numerous methods of source code authorship attribution have been proposed and studied. However, there are no known easily accessible and user-friendly programs that perform this task. Instead, researchers typically develop software in an ad hoc manner for use in their studies, and the software is rarely made publicly available. In this paper, we present a software tool called A Source Code Authorship Program (ASAP), which is suitable to be used by either the layperson or the expert. An author can be attributed to individual documents one at a time, or complex authorship attribution experiments can easily be performed on large datasets. In this paper, the interface and implementation of the ASAP tool is presented, and the tool is validated by using it to replicate previously published authorship attribution experiments

Listening between the Lines: Learning Personal Attributes from Conversations

Open-domain dialogue agents must be able to converse about many topics while incorporating knowledge about the user into the conversation. In this work we address the acquisition of such knowledge, for personalization in downstream Web applications, by extracting personal attributes from conversations. This problem is more challenging than the established task of information extraction from scientific publications or Wikipedia articles, because dialogues often give merely implicit cues about the speaker. We propose methods for inferring personal attributes, such as profession, age or family status, from conversations using deep learning. Specifically, we propose several Hidden Attribute Models, which are neural networks leveraging attention mechanisms and embeddings. Our methods are trained on a per-predicate basis to output rankings of object values for a given subject-predicate combination (e.g., ranking the doctor and nurse professions high when speakers talk about patients, emergency rooms, etc). Experiments with various conversational texts including Reddit discussions, movie scripts and a collection of crowdsourced personal dialogues demonstrate the viability of our methods and their superior performance compared to state-of-the-art baselines.Comment: published in WWW'1

Clades of huge phages from across Earth's ecosystems.

Bacteriophages typically have small genomes1 and depend on their bacterial hosts for replication2. Here we sequenced DNA from diverse ecosystems and found hundreds of phage genomes with lengths of more than 200 kilobases (kb), including a genome of 735 kb, which is-to our knowledge-the largest phage genome to be described to date. Thirty-five genomes were manually curated to completion (circular and no gaps). Expanded genetic repertoires include diverse and previously undescribed CRISPR-Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribosomal proteins. The CRISPR-Cas systems of phages have the capacity to silence host transcription factors and translational genes, potentially as part of a larger interaction network that intercepts translation to redirect biosynthesis to phage-encoded functions. In addition, some phages may repurpose bacterial CRISPR-Cas systems to eliminate competing phages. We phylogenetically define the major clades of huge phages from human and other animal microbiomes, as well as from oceans, lakes, sediments, soils and the built environment. We conclude that the large gene inventories of huge phages reflect a conserved biological strategy, and that the phages are distributed across a broad bacterial host range and across Earth's ecosystems

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia.

ObjectiveInflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.Study designA sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios.ResultsHigher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia.ConclusionsAmong women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth