On optimal designs for clinical trials: An updated review

Optimization of clinical trial designs can help investigators achieve higher qualityresults for the given resource constraints. The present paper gives an overviewof optimal designs for various important problems that arise in different stages ofclinical drug development, including phase I dose–toxicity studies; phase I/II studiesthat consider early efficacy and toxicity outcomes simultaneously; phase IIdose–response studies driven by multiple comparisons (MCP), modeling techniques(Mod), or their combination (MCP–Mod); phase III randomized controlled multiarmmulti-objective clinical trials to test difference among several treatment groups;and population pharmacokinetics–pharmacodynamics experiments. We find thatmodern literature is very rich with optimal design methodologies that can be utilizedby clinical researchers to improve efficiency of drug development

Sum Throughput Maximization in Multi-Tag Backscattering to Multiantenna Reader

Backscatter communication (BSC) is being realized as the core technology for pervasive sustainable Internet-of-Things applications. However, owing to the resource-limitations of passive tags, the efficient usage of multiple antennas at the reader is essential for both downlink excitation and uplink detection. This work targets at maximizing the achievable sum-backscattered-throughput by jointly optimizing the transceiver (TRX) design at the reader and backscattering coefficients (BC) at the tags. Since, this joint problem is nonconvex, we first present individually-optimal designs for the TRX and BC. We show that with precoder and {combiner} designs at the reader respectively targeting downlink energy beamforming and uplink Wiener filtering operations, the BC optimization at tags can be reduced to a binary power control problem. Next, the asymptotically-optimal joint-TRX-BC designs are proposed for both low and high signal-to-noise-ratio regimes. Based on these developments, an iterative low-complexity algorithm is proposed to yield an efficient jointly-suboptimal design. Thereafter, we discuss the practical utility of the proposed designs to other application settings like wireless powered communication networks and BSC with imperfect channel state information. Lastly, selected numerical results, validating the analysis and shedding novel insights, demonstrate that the proposed designs can yield significant enhancement in the sum-backscattered throughput over existing benchmarks.Comment: 17 pages, 5 figures, accepted for publication in IEEE Transactions on Communication

Coordinated Multicast Beamforming in Multicell Networks

We study physical layer multicasting in multicell networks where each base station, equipped with multiple antennas, transmits a common message using a single beamformer to multiple users in the same cell. We investigate two coordinated beamforming designs: the quality-of-service (QoS) beamforming and the max-min SINR (signal-to-interference-plus-noise ratio) beamforming. The goal of the QoS beamforming is to minimize the total power consumption while guaranteeing that received SINR at each user is above a predetermined threshold. We present a necessary condition for the optimization problem to be feasible. Then, based on the decomposition theory, we propose a novel decentralized algorithm to implement the coordinated beamforming with limited information sharing among different base stations. The algorithm is guaranteed to converge and in most cases it converges to the optimal solution. The max-min SINR (MMS) beamforming is to maximize the minimum received SINR among all users under per-base station power constraints. We show that the MMS problem and a weighted peak-power minimization (WPPM) problem are inverse problems. Based on this inversion relationship, we then propose an efficient algorithm to solve the MMS problem in an approximate manner. Simulation results demonstrate significant advantages of the proposed multicast beamforming algorithms over conventional multicasting schemes.Comment: 10pages, 9 figure

Ergodic Randomized Algorithms and Dynamics over Networks

Algorithms and dynamics over networks often involve randomization, and randomization may result in oscillating dynamics which fail to converge in a deterministic sense. In this paper, we observe this undesired feature in three applications, in which the dynamics is the randomized asynchronous counterpart of a well-behaved synchronous one. These three applications are network localization, PageRank computation, and opinion dynamics. Motivated by their formal similarity, we show the following general fact, under the assumptions of independence across time and linearities of the updates: if the expected dynamics is stable and converges to the same limit of the original synchronous dynamics, then the oscillations are ergodic and the desired limit can be locally recovered via time-averaging.Comment: 11 pages; submitted for publication. revised version with fixed technical flaw and updated reference