Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development

The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage. Abnormalities of several neurohormonal mechanisms controlling blood pressure homeostasis and cardiovascular remodeling can contribute to these pathological conditions. The natriuretic peptide (NP) family (including ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide), and CNP (C-type natriuretic peptide)), the NP receptors (NPRA, NPRB, and NPRC), and the related protease convertases (furin, corin, and PCSK6) constitute the NP system and represent relevant protective mechanisms toward the development of hypertension and associated conditions, such as atherosclerosis, stroke, myocardial infarction, heart failure, and renal injury. Initially, several experimental studies performed in different animal models demonstrated a key role of the NP system in the development of hypertension. Importantly, these studies provided relevant insights for a better comprehension of the pathogenesis of hypertension and related cardiovascular phenotypes in humans. Thus, investigation of the role of NPs in hypertension offers an excellent example in translational medicine. In this review article, we will summarize the most compelling evidence regarding the molecular mechanisms underlying the physiological and pathological impact of NPs on blood pressure regulation and on hypertension development. We will also discuss the protective effect of NPs toward the increased susceptibility to hypertensive target organ damage

Efficient protection schemes for hybrid WDM/TDM passive optical networks

Hybrid WDM/TDM Passive Optical Network (PON) is a promising candidate for next-generation optical access (NGOA) solutions as it is able to offer a high splitting ratio and consequently achieves a relatively low cost and power consumption on a per-user basis compared with other NGOA architectures. On the other hand, the end users require a certain level of connection availability while the operators need to reduce the failure impact (i.e. to avoid a huge number of end users being affected by any single failure). Therefore, by evaluating the connection availability and failure impact robustness we identify the most efficient parts to provide resilience in a hybrid WDM/TDM PON from an operator and an end-user perspective. Then, we select the appropriate protection schemes to construct some novel reliable architectures and analyze their reliability performance in urban and rural scenarios. In this way, this paper provides a comprehensive insight into the most relevant protection mechanisms for hybrid WDM/TDM PONs

Genome-wide association studies of the self-rating of effects of ethanol (SRE).

The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h2 : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (rg : 0.35-0.76). Genome-wide significant associations were observed (SRE-T: chromosomes 6, rs140154945, COGA-EA P = 3.30E-08 and 11, rs10647170, COGA-AA+EA P = 3.53E-09; SRE-5: chromosome13, rs4770359, COGA-AA P = 2.92E-08). Chromosome 11 was replicated in an EA dataset from the National Institute on Alcohol Abuse and Alcoholism intramural program. In silico functional analyses and RNA expression analyses suggest that the chromosome 6 locus is an eQTL for KIF25. Polygenic risk scores derived using the COGA SRE-T and SRE-5 GWAS predicted 0.47% to 2.48% of variances in AD and DSM-IV AD criterion count in independent datasets. This study highlights the genetic contribution of alcohol response phenotypes to the etiology of alcohol use disorders

Trade-off between end-to-end reliable and cost-effective TDMA/WDM passive optical networks

Hybrid TDMA/VVDM (TWDM) Passive Optical Network (PON) is a promising candidate for Next-Generation PON (NG-PON) solutions. We propose end-to end reliable architectures for business users and a cost-effective network for residential users. We evaluate the proposed reliable architectures in terms of protection coverage, connection availability, impact of failure (i.e. to avoid a huge number of end users being affected by any single failure) and cost in different populated scenarios

Incentives for nature conservation in urban landscapes

The aim of this article is to contribute to the development of ecological-economic incentives in conservation policy. Our approach uses strategies for establishing habitat networks as an example to develop spatially-oriented incentives in urban landscapes. The incentives should ideally consider aspects both of ecological effectiveness and economic efficiency. Our understanding of ecological-economic incentives reaches beyond this stage: not only must economic incentives in environmental policy be based on ecological knowledge, but also, they have to consider social aspects of implementation and acceptance. The ecological analysis of strategies for species protection in urban landscapes leads to management recommendations as a basis for the specification of environmental policy goals. Based on ecological knowledge, which shows where to invest scarce resources, the economic perspective aims at analysing and evaluating environmental policy instruments for their suitability and efficiency. The ecological and economic research is to be combined with a sociological approach, which investigates the choice and application of environmental policy measures as a system of social action. The analysis of problems of implementation and acceptance will be used to support the introduction of new instruments or to improve existing incentive systems related to nature conservation in urban landscapes. For this purpose, a survey was carried out on the use of environmental policy instruments (regulation, planning, economic incentives, communication, information) in German cities in 1997. Furthermore, two existing economic instruments in German nature protection policy are analysed in detail: the compensation charge as part of the impact regulation and incentive programmes on the level of the German federal states that offer financial incentive measures for nature protection. --