The safety case and the lessons learned for the reliability and maintainability case

This paper examine the safety case and the lessons learned for the reliability and maintainability case

Rejuvenation and the Age of Information

International audienc

Envelhecimento e rejuvenescimento de software: 20 anos (19952014) - panorama e desafios

Although software aging and rejuvenation is a young research held, in its first 20 years a lot of knowledge has been produced. Nowadays, important scientific journals and conferences include SAR-related topics in their scope of interest. This fast growing and wide range of dissemination venues pose a challenge to researchers to keep tracking of the new findings and trends in this area. In this work, we collected and analyzed SAR research data to detect trends, patterns, and thematic gaps, in order to provide a comprehensive view of this research held over its hrst 20 years. Adopted the systematic mapping approach to answer research questions such as: How the main topics investigated in SAR have evolved over time? Which are the most investigated aging effects? Which rejuvenation techniques and strategies are more frequently used?CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDissertação (Mestrado)Embora o envelhecimento e rejuvenescimento de software seja um campo de pesquisa novo, em seus primeiros 20 anos muito conhecimento foi produzido. Hoje em dia, revistas e conferências científicas importantes incluem temas relacionados a SAR no seu âmbito de interesse. Este crescimento rápido e a grande variedade de locais de disseminação representam um desafio para os pesquisadores para manter o acompanhamento das novas descobertas e tendências nesta área. Neste trabalho, foram coletados e analisados dados de pesquisa em SAR para detectar tendências, padrões e lacunas temáticas, a hm de proporcionar uma visão abrangente deste campo de pesquisa em seus primeiros 20 anos. Adotou-se a abordagem de mapeamento sistemático para responder a perguntas de pesquisa, tais como: Como os principais temas investigados em SAR têm evoluído ao longo do tempo? Quais são os efeitos do envelhecimento mais investigados? Quais técnicas e estratégias de rejuvenescimento são mais frequentemente usadas

An Evaluation of Five Years of The California Wellness Foundation's Sabbatical Program

Evaluates the impact of TCWF's program to improve the long-term effectiveness of health-related nonprofits through sabbatical grants to executive directors and support for their nonprofits. Examines benefits for both individuals and organizations

The emergence and development of knowledge intensive mining service suppliers in the late 20th century

During the late 20th Century the mining industry went through an important technological rejuvenation that drove high rates of innovation, productivity growth and organisational change. This process included the emergence of knowledge-intensive mining services (KIMS) suppliers, who performed functions outsourced by mining companies, gradually strengthening their capabilities, enlarging their geographical scope and becoming a globally organised sector. But this was uneven across different mining economies. For instance, while numerous Australian KIMS suppliers emerged and achieved international competitiveness, few did this in Chile. Focusing on Chile, this thesis explores the reasons for the limited development of KIMS suppliers in a developing mining economy. It examines the technological learning that shaped the KIMS sector evolution in Chile by contrasting it with the Australian experience, using a two level learning model that integrates: (1) the interaction between industry-level factors that shaped the potential for learning at the micro-level; and (2) the interaction at the micro-level between accumulated capabilities and learning efforts by firms to exploit the potential for learning. KIMS learning is examined over four stages: (i) Gestation (1940s - early 1970s); (ii) Emergence and Development (mid-1970s to early 1980s); (iii) Internationalisation (late 1980s to late 1990s); and (iv) Consolidation (early 2000s and still going on). Over these stages, KIMS sector learning was much more limited in Chile than Australia, either because there was a lower learning potential and/or because firms carried out limited learning efforts to exploit the potential. At the first stage mining companies in Chile played a weak role as incubators of KIMS capabilities. Consequently, during the second stage there were few KIMS suppliers capable of profiting from the rejuvenation being experienced by the global industry. Also, with limited stimuli from the growth of mining in Chile, suppliers undertook limited learning efforts. So, the third stage found Chilean KIMS suppliers unprepared to exploit the learning potential that came with internationalisation; and the learning opportunities inherent in the significant expansion of Chilean mining production were captured by foreign KIMS suppliers, including Australians. Accordingly, Chilean KIMS suppliers started the Consolidation Stage without the capabilities to overcome the increasing barriers to participation in the industry‟s continuing high learning potential

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on both human (chromosome 17) and murine (chromosome 11) genomes. In human breast and ovarian cancers, the monoallelic deletion of these genes is often co-occurring. To investigate the potential tumor suppressor roles of two of the most commonly deleted autophagy genes in ovarian cancer, BECN1 and MAP1LC3B were knocked-down in atypical (BECN1+/+ and MAP1LC3B+/+) ovarian cancer cells. Ultra-performance liquid chromatography mass-spectrometry metabolomics revealed reduced levels of acetyl-CoA which corresponded with elevated levels of glycerophospholipids and sphingolipids. Migration rates of ovarian cancer cells were increased upon autophagy gene knockdown. Genomic instability was increased, resulting in copy-number alteration patterns which mimicked high grade serous ovarian cancer. We further investigated the causal role of Becn1 haploinsufficiency for oncogenesis in a MISIIR SV40 large T antigen driven spontaneous ovarian cancer mouse model. Tumors were evident earlier among the Becn1+/- mice, and this correlated with an increase in copy-number alterations per chromosome in the Becn1+/- tumors. The results support monoallelic loss of BECN1 as permissive for tumor initiation and potentiating for genomic instability in ovarian cancer

Development of a Wireless Real-Time Productivity Measurement System for Rapid Bridge Replacement

Increased attention has been paid to rapid bridge replacement, one of the critical components of the nation’s transportation network, since the terrorist attacks on September 11, 2001. To enhance the capability of rapid replacement of damaged bridges after extreme events, a prototype wireless real-time productivity measurement system has been developed. The developed system has a potential not only to improve the accuracy of construction schedule but also to strengthen the communication and coordination among parties involved in the replacement process after extreme events by providing accurate productivity information in real time. To validate the developed system, field experiments were conducted at three construction sites. Results of data analyses indicate that it is feasible to use the developed system to measure on-site productivity in real time; and productivity measurements were accurate and could be shared among all parties involved in the replacement process

Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis

Dietary restriction (DR) and rapamycin both increase lifespan across a number of taxa. Despite this positive effect on lifespan and other aspects of health, reductions in some physiological functions have been reported for DR, and rapamycin has been used as an immunosuppressant. Perhaps surprisingly, both interventions have been suggested to improve immune function and delay immunosenescence. The immune system is complex and consists of many components. Therefore, arguably, the most holistic measurement of immune function is survival from an acute pathogenic infection. We reanalysed published post-infection short-term survival data of mice (n = 1223 from 23 studies comprising 46 effect sizes involving DR (n = 17) and rapamycin treatment (n = 29) and analysed these results using meta-analysis. Rapamycin treatment significantly increased post infection survival rate (lnHR =  − 0.72; CI =  − 1.17, -0.28; p = 0.0015). In contrast, DR reduced post-infection survival (lnHR = 0.80; CI = 0.08, 1.52; p = 0.03). Importantly, the overall effect size of rapamycin treatment was significantly lower (p < 0.001) than the estimate from DR studies, suggesting opposite effects on immune function. Our results show that immunomodulation caused by rapamycin treatment is beneficial to the survival from acute infection. For DR, our results are based on a smaller number of studies, but do warrant caution as they indicate possible immune costs of DR. Our quantitative synthesis suggests that the geroprotective effects of rapamycin extend to the immune system and warrants further clinical trials of rapamycin to boost immunity in humans

Predictive Reliability and Fault Management in Exascale Systems: State of the Art and Perspectives

© ACM, 2020. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in ACM Computing Surveys, Vol. 53, No. 5, Article 95. Publication date: September 2020. https://doi.org/10.1145/3403956[EN] Performance and power constraints come together with Complementary Metal Oxide Semiconductor technology scaling in future Exascale systems. Technology scaling makes each individual transistor more prone to faults and, due to the exponential increase in the number of devices per chip, to higher system fault rates. Consequently, High-performance Computing (HPC) systems need to integrate prediction, detection, and recovery mechanisms to cope with faults efficiently. This article reviews fault detection, fault prediction, and recovery techniques in HPC systems, from electronics to system level. We analyze their strengths and limitations. Finally, we identify the promising paths to meet the reliability levels of Exascale systems.This work has received funding from the European Union's Horizon 2020 (H2020) research and innovation program under the FET-HPC Grant Agreement No. 801137 (RECIPE). Jaume Abella was also partially supported by the Ministry of Economy and Competitiveness of Spain under Contract No. TIN2015-65316-P and under Ramon y Cajal Postdoctoral Fellowship No. RYC-2013-14717, as well as by the HiPEAC Network of Excellence. Ramon Canal is partially supported by the Generalitat de Catalunya under Contract No. 2017SGR0962.Canal, R.; Hernández Luz, C.; Tornero-Gavilá, R.; Cilardo, A.; Massari, G.; Reghenzani, F.; Fornaciari, W.... (2020). Predictive Reliability and Fault Management in Exascale Systems: State of the Art and Perspectives. ACM Computing Surveys. 53(5):1-32. https://doi.org/10.1145/3403956S132535Abella, J., Hernandez, C., Quinones, E., Cazorla, F. J., Conmy, P. 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