Brain–computer interface game applications for combined neurofeedback and biofeedback treatment for children on the autism spectrum

Individuals with Autism Spectrum Disorder (ASD) show deficits in social and communicative skills, including imitation, empathy, and shared attention, as well as restricted interests and repetitive patterns of behaviors. Evidence for and against the idea that dysfunctions in the mirror neuron system are involved in imitation and could be one underlying cause for ASD is discussed in this review. Neurofeedback interventions have reduced symptoms in children with ASD by self-regulation of brain rhythms. However, cortical deficiencies are not the only cause of these symptoms. Peripheral physiological activity, such as the heart rate, is closely linked to neurophysiological signals and associated with social engagement. Therefore, a combined approach targeting the interplay between brain, body and behavior could be more effective. Brain-computer interface applications for combined neurofeedback and biofeedback treatment for children with ASD are currently nonexistent. To facilitate their use, we have designed an innovative game that includes social interactions and provides neural- and body-based feedback that corresponds directly to the underlying significance of the trained signals as well as to the behavior that is reinforced

Human summating potential using continuous loop averaging deconvolution: Response amplitudes vary with tone burst repetition rate and duration

Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimulus repetition rates. To allow for the analysis of the complex ECochG responses to high rates, we deconvolved responses using the Continuous Loop Averaging Deconvolution (CLAD) technique. We examined the effect of high stimulus repetition rate and stimulus duration on SP amplitude measurements made with extratympanic ECochG to tone bursts in 20 adult females with normal hearing. We used 500 and 2,000 Hz tone bursts of various stimulus durations (12, 6, 3 ms) and repetition rates (five rates ranging from 7.1 to 234.38/s). A within-subject repeated measures (rate x duration) analysis of variance was conducted. We found that, for both 500 and 2,000 Hz stimuli, the mean deconvolved SP amplitudes were larger at faster repetition rates (58.59 and 97.66/s) compared to slower repetition rates (7.1 and 19.53/s), and larger at shorter stimulus duration compared longer stimulus duration. Our concluding hypothesis is that large SP amplitude to short duration stimuli may originate primarily from neural excitation, and large SP amplitudes to long duration, fast repetition rate stimuli may originate from hair cell responses. While the hair cell or neural origins of the SP to various stimulus parameters remains to be validated, our results nevertheless provide normative data as a step toward applying the CLAD technique to understanding diseased ears

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions

No abstract available

Smart Embedded Passive Acoustic Devices for Real-Time Hydroacoustic Surveys

This paper describes cost-efficient, innovative and interoperable ocean passive acoustics sensors systems, developed within the European FP7 project NeXOS (Next generation Low-Cost Multifunctional Web Enabled Ocean Sensor Systems Empowering Marine, Maritime and Fisheries Management) These passive acoustic sensors consist of two low power, innovative digital hydrophone systems with embedded processing of acoustic data, A1 and A2, enabling real-time measurement of the underwater soundscape. An important part of the effort is focused on achieving greater dynamic range and effortless integration on autonomous platforms, such as gliders and profilers. A1 is a small standalone, compact, low power, low consumption digital hydrophone with embedded pre-processing of acoustic data, suitable for mobile platforms with limited autonomy and communication capability. A2 consists of four A1 digital hydrophones with Ethernet interface and one master unit for data processing, enabling real-time measurement of underwater noise and soundscape sources. In this work the real-time acoustic processing algorithms implemented for A1 and A2 are described, including computational load evaluations of the algorithms. The results obtained from the real time test done with the A2 assembly at OBSEA observatory collected during the verification phase of the project are presented.Postprint (author's final draft

Diverse Aging and Health Inequality by Race and Ethnicity

Although gerontologists have long embraced the concept of heterogeneity in theories and models of aging, recent research reveals the importance of racial and ethnic diversity on life course processes leading to health inequality. This article examines research on health inequality by race and ethnicity and identifies theoretical and methodological innovations that are transforming the study of health disparities. Drawing from cumulative inequality theory, we propose greater use of life course analysis, more attention to variability within racial and ethnic groups, and better integration of environmental context into the study of accumulation processes leading to health disparities

US Army remotely piloted vehicle supporting technology program

Essential technology programs that lead to the full scale engineering development of the Aquila Remotely Piloted Vehicle system for U.S. Army are described. The Aquila system uses a small recoverable and reusable RPV to provide target acquisition, designation, and aerial reconnaissance mission support for artillery and smart munitions. Developments that will provide growth capabilities to the Aquila RPV system, as well as future RPV mission concepts being considered by the U.S. Army are presented

The story of Oh: the aesthetics and rhetoric of a common vowel sound

Studies in Musical Theatre is the only peer-reviewed journal dedicated to musical theatre. It was launched in 2007 and is now in its seventh volume. It has an extensive international readership and is edited by Dominic Symonds and George Burrows. This article investigates the use of the ‘word’ ‘Oh’ in a variety of different performance idioms. Despite its lack of ‘meaning’, the sound is used in both conversation and poetic discourse, and I discuss how it operates communicatively and expressively through contextual resonances, aesthetic manipulation and rhetorical signification. The article first considers the aesthetically modernist work of Cathy Berberian in Bussotti’s La Passion Selon Sade; then it considers the rhetorically inflected use of ‘Oh’ to construct social resonance in popular song;finally, it discusses two important uses of the sound ‘Oh’ which bookend the Broadway musical Oklahoma!, serving to consolidate the allegorical and musico-dramatic narrative of the show