Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data

In systems biomedicine, an experimenter encounters different potential sources of variation in data such as individual samples, multiple experimental conditions, and multi-variable network-level responses. In multiparametric cytometry, which is often used for analyzing patient samples, such issues are critical. While computational methods can identify cell populations in individual samples, without the ability to automatically match them across samples, it is difficult to compare and characterize the populations in typical experiments, such as those responding to various stimulations or distinctive of particular patients or time-points, especially when there are many samples. Joint Clustering and Matching (JCM) is a multi-level framework for simultaneous modeling and registration of populations across a cohort. JCM models every population with a robust multivariate probability distribution. Simultaneously, JCM fits a random-effects model to construct an overall batch template -- used for registering populations across samples, and classifying new samples. By tackling systems-level variation, JCM supports practical biomedical applications involving large cohorts

Bayesian Learning of Asymmetric Gaussian-Based Statistical Models using Markov Chain Monte Carlo Techniques

A novel unsupervised Bayesian learning framework based on asymmetric Gaussian mixture (AGM) statistical model is proposed since AGM is shown to be more effective compared to the classic Gaussian mixture. The Bayesian learning framework is developed by adopting sampling-based Markov chain Monte Carlo (MCMC) methodology. More precisely, the fundamental learning algorithm is a hybrid Metropolis-Hastings within Gibbs sampling solution which is integrated within a reversible jump MCMC (RJMCMC) learning framework, a self-adapted sampling-based MCMC implementation, that enables model transfer throughout the mixture parameters learning process, therefore, automatically converges to the optimal number of data groups. Furthermore, a feature selection technique is included to tackle the irrelevant and unneeded information from datasets. The performance comparison between AGM and other popular solutions is given and both synthetic and real data sets extracted from challenging applications such as intrusion detection, spam filtering and image categorization are evaluated to show the merits of the proposed approach

Finite Bivariate and Multivariate Beta Mixture Models Learning and Applications

Finite mixture models have been revealed to provide flexibility for data clustering. They have demonstrated high competence and potential to capture hidden structure in data. Modern technological progresses, growing volumes and varieties of generated data, revolutionized computers and other related factors are contributing to produce large scale data. This fact enhances the significance of finding reliable and adaptable models which can analyze bigger, more complex data to identify latent patterns, deliver faster and more accurate results and make decisions with minimal human interaction. Adopting the finest and most accurate distribution that appropriately represents the mixture components is critical. The most widely adopted generative model has been the Gaussian mixture. In numerous real-world applications, however, when the nature and structure of data are non-Gaussian, this modelling fails. One of the other crucial issues when using mixtures is determination of the model complexity or number of mixture components. Minimum message length (MML) is one of the main techniques in frequentist frameworks to tackle this challenging issue. In this work, we have designed and implemented a finite mixture model, using the bivariate and multivariate Beta distributions for cluster analysis and demonstrated its flexibility in describing the intrinsic characteristics of the observed data. In addition, we have applied our estimation and model selection algorithms to synthetic and real datasets. Most importantly, we considered interesting applications such as in image segmentation, software modules defect prediction, spam detection and occupancy estimation in smart buildings