176 research outputs found
Hybrid-space reconstruction with add-on distortion correction for simultaneous multi-slab diffusion MRI
Purpose: This study aims to propose a model-based reconstruction algorithm
for simultaneous multi-slab diffusion MRI acquired with blipped-CAIPI gradients
(blipped-SMSlab), which can also incorporate distortion correction.
Methods: We formulate blipped-SMSlab in a 4D k-space with kz gradients for
the intra-slab slice encoding and km (blipped-CAIPI) gradients for the
inter-slab encoding. Because kz and km gradients share the same physical axis,
the blipped-CAIPI gradients introduce phase interference in the z-km domain
while motion induces phase variations in the kz-m domain. Thus, our previous
k-space-based reconstruction would need multiple steps to transform data back
and forth between k-space and image space for phase correction. Here we propose
a model-based hybrid-space reconstruction algorithm to correct the phase errors
simultaneously. Moreover, the proposed algorithm is combined with distortion
correction, and jointly reconstructs data acquired with the blip-up/down
acquisition to reduce the g-factor penalty.
Results: The blipped-CAIPI-induced phase interference is corrected by the
hybrid-space reconstruction. Blipped-CAIPI can reduce the g-factor penalty
compared to the non-blipped acquisition in the basic reconstruction.
Additionally, the joint reconstruction simultaneously corrects the image
distortions and improves the 1/g-factors by around 50%. Furthermore, through
the joint reconstruction, SMSlab acquisitions without the blipped-CAIPI
gradients also show comparable correction performance with blipped-SMSlab.
Conclusion: The proposed model-based hybrid-space reconstruction can
reconstruct blipped-SMSlab diffusion MRI successfully. Its extension to a joint
reconstruction of the blip-up/down acquisition can correct EPI distortions and
further reduce the g-factor penalty compared with the separate reconstruction.Comment: 10 figures+tables, 8 supplementary figure
Accelerated mapping of magnetic susceptibility using 3D planes-on-a-paddlewheel (POP) EPI at ultra-high field strength
With the advent of ultra-high field MRI scanners in clinical research, susceptibility based MRI has recently gained increasing interest because of its potential to assess subtle tissue changes underlying neurological pathologies/disorders. Conventional, but rather slow, three-dimensional (3D) spoiled gradient-echo (GRE) sequences are typically employed to assess the susceptibility of tissue. 3D echo-planar imaging (EPI) represents a fast alternative but generally comes with echo-time restrictions, geometrical distortions and signal dropouts that can become severe at ultra-high fields. In this work we assess quantitative susceptibility mapping (QSM) at 7T using non-Cartesian 3D EPI with a planes-on-a-paddlewheel (POP) trajectory, which is created by rotating a standard EPI readout train around its own phase encoding axis. We show that the threefold accelerated non-Cartesian 3D POP EPI sequence enables very fast, whole brain susceptibility mapping at an isotropic resolution of 1mm and that the high image quality has sufficient signal-to-noise ratio in the phase data for reliable QSM processing. The susceptibility maps obtained were comparable with regard to QSM values and geometric distortions to those calculated from a conventional 4min 3D GRE scan using the same QSM processing pipeline
SMS MUSSELS: A Navigator-free Reconstruction for Simultaneous MultiSlice Accelerated MultiShot Diffusion Weighted Imaging
Purpose: To introduce a novel reconstruction method for simultaneous
multi-slice (SMS) accelerated multi shot diffusion weighted imaging (ms-DWI).
Methods: SMS acceleration using blipped CAIPI schemes have been proposed to
speed up the acquisition of ms-DWIs. The reconstruction of the above data
requires (i) phase compensation to combine data from different shots and (ii)
slice unfolding to separate the data of different slices. The traditional
approach is to first estimate the phase maps corresponding to each shot from a
navigator or from the slice-aliased individual shot data. The phase maps are
subsequently fed to a iterative reconstruction scheme to recover the slice
unfolded DWIs. We propose a novel reconstruction method to jointly recover the
slice-unfolded k-space data of the multiple shots. The proposed reconstruction
is enabled by the low-rank property inherent in the k-space samples of a ms-DW
acquisition. Specifically, we recover the missing samples of the multi-shot
acquisition by enforcing a low-rank penalty on the block-Hankel matrix formed
by the k-space data of each shot for each slice. The joint recovery of the
slice-unfolded k-space data is then performed using a SENSE-based
slice-unfolding subject to the low-rank constraint. The proposed joint recovery
scheme is tested on simulated and in-vivo data and compared to similar
un-navigated methods at slice acceleration factors of 2 and 3. Results: Our
experiments show effective slice unaliasing and successful recovery of DWIs
with minimal phase artifacts using the proposed method. The performance is
comparable to existing methods at low acceleration factors and better than
existing methods as the acceleration factor increase. Conclusion: For the slice
acceleration factors considered in this study, the proposed method can
successfully recover DWIs from SMS-accelerated ms-DWI acquisitions
Highly efficient MRI through multi-shot echo planar imaging
Multi-shot echo planar imaging (msEPI) is a promising approach to achieve
high in-plane resolution with high sampling efficiency and low T2* blurring.
However, due to the geometric distortion, shot-to-shot phase variations and
potential subject motion, msEPI continues to be a challenge in MRI. In this
work, we introduce acquisition and reconstruction strategies for robust,
high-quality msEPI without phase navigators. We propose Blip Up-Down
Acquisition (BUDA) using interleaved blip-up and -down phase encoding, and
incorporate B0 forward-modeling into Hankel structured low-rank model to enable
distortion- and navigator-free msEPI. We improve the acquisition efficiency and
reconstruction quality by incorporating simultaneous multi-slice acquisition
and virtual-coil reconstruction into the BUDA technique. We further combine
BUDA with the novel RF-encoded gSlider acquisition, dubbed BUDA-gSlider, to
achieve rapid high isotropic-resolution MRI. Deploying BUDA-gSlider with
model-based reconstruction allows for distortion-free whole-brain 1mm isotropic
T2 mapping in about 1 minute. It also provides whole-brain 1mm isotropic
diffusion imaging with high geometric fidelity and SNR efficiency. We finally
incorporate sinusoidal wave gradients during the EPI readout to better use coil
sensitivity encoding with controlled aliasing.Comment: 13 pages, 10 figure
Navigator-free EPI Ghost Correction with Structured Low-Rank Matrix Models: New Theory and Methods
Structured low-rank matrix models have previously been introduced to enable
calibrationless MR image reconstruction from sub-Nyquist data, and such ideas
have recently been extended to enable navigator-free echo-planar imaging (EPI)
ghost correction. This paper presents novel theoretical analysis which shows
that, because of uniform subsampling, the structured low-rank matrix
optimization problems for EPI data will always have either undesirable or
non-unique solutions in the absence of additional constraints. This theory
leads us to recommend and investigate problem formulations for navigator-free
EPI that incorporate side information from either image-domain or k-space
domain parallel imaging methods. The importance of using nonconvex low-rank
matrix regularization is also identified. We demonstrate using phantom and
\emph{in vivo} data that the proposed methods are able to eliminate ghost
artifacts for several navigator-free EPI acquisition schemes, obtaining better
performance in comparison to state-of-the-art methods across a range of
different scenarios. Results are shown for both single-channel acquisition and
highly accelerated multi-channel acquisition.Comment: 13 pages, 9 figures ; Submitted to IEEE Transactions on Medical
Imagin
Robust Autocalibrated Structured Low-Rank EPI Ghost Correction
Purpose: We propose and evaluate a new structured low-rank method for EPI
ghost correction called Robust Autocalibrated LORAKS (RAC-LORAKS). The method
can be used to suppress EPI ghosts arising from the differences between
different readout gradient polarities and/or the differences between different
shots. It does not require conventional EPI navigator signals, and is robust to
imperfect autocalibration data.
Methods: Autocalibrated LORAKS is a previous structured low-rank method for
EPI ghost correction that uses GRAPPA-type autocalibration data to enable
high-quality ghost correction. This method works well when the autocalibration
data is pristine, but performance degrades substantially when the
autocalibration information is imperfect. RAC-LORAKS generalizes Autocalibrated
LORAKS in two ways. First, it does not completely trust the information from
autocalibration data, and instead considers the autocalibration and EPI data
simultaneously when estimating low-rank matrix structure. And second, it uses
complementary information from the autocalibration data to improve EPI
reconstruction in a multi-contrast joint reconstruction framework. RAC-LORAKS
is evaluated using simulations and in vivo data, including comparisons to
state-of-the-art methods.
Results: RAC-LORAKS is demonstrated to have good ghost elimination
performance compared to state-of-the-art methods in several complicated EPI
acquisition scenarios (including gradient-echo brain imaging, diffusion-encoded
brain imaging, and cardiac imaging).
Conclusion: RAC-LORAKS provides effective suppression of EPI ghosts and is
robust to imperfect autocalibration data
Distortion and Signal Loss in Medial Temporal Lobe
Background: The medial temporal lobe (MTL) contains subregions that are subject to severe distortion and signal loss in functional MRI. Air/tissue and bone/tissue interfaces in the vicinity of the MTL distort the local magnetic field due to differences in magnetic susceptibility. Fast image acquisition and thin slices can reduce the amount of distortion and signal loss, but at the cost of image signal-to-noise ratio (SNR). Methodology/Principal Findings: In this paper, we quantify the severity of distortion and signal loss in MTL subregions for three different echo planar imaging (EPI) acquisitions at 3 Tesla: a conventional moderate-resolution EPI (36363 mm), a conventional high-resolution EPI (1.561.562 mm), and a zoomed high-resolution EPI. We also demonstrate the advantage of reversing the phase encode direction to control the direction of distortion and to maximize efficacy of distortion compensation during data post-processing. With the high-resolution zoomed acquisition, distortion is not significant and signal loss is present only in the most anterior regions of the parahippocampal gyrus. Furthermore, we find that the severity of signal loss is variable across subjects, with some subjects showing negligible loss and others showing more dramatic loss. Conclusions/Significance: Although both distortion and signal loss are minimized in a zoomed field of view acquisition with thin slices, this improvement in accuracy comes at the cost of reduced SNR. We quantify this trade-off between distortion and SNR in order to provide a decision tree for design of high-resolution experiments investigating the functio
What's new and what's next in diffusion MRI preprocessing
Diffusion MRI (dMRI) provides invaluable information for the study of tissue microstructure and brain connectivity, but suffers from a range of imaging artifacts that greatly challenge the analysis of results and their interpretability if not appropriately accounted for. This review will cover dMRI artifacts and preprocessing steps, some of which have not typically been considered in existing pipelines or reviews, or have only gained attention in recent years: brain/skull extraction, B-matrix incompatibilities w.r.t the imaging data, signal drift, Gibbs ringing, noise distribution bias, denoising, between- and within-volumes motion, eddy currents, outliers, susceptibility distortions, EPI Nyquist ghosts, gradient deviations, bias fields, and spatial normalization. The focus will be on “what’s new” since the notable advances prior to and brought by the Human Connectome Project (HCP), as presented in the predecessing issue on “Mapping the Connectome” in 2013. In addition to the development of novel strategies for dMRI preprocessing, exciting progress has been made in the availability of open source tools and reproducible pipelines, databases and simulation tools for the evaluation of preprocessing steps, and automated quality control frameworks, amongst others. Finally, this review will consider practical considerations and our view on “what’s next” in dMRI preprocessing
Motion robust acquisition and reconstruction of quantitative T2* maps in the developing brain
The goal of the research presented in this thesis was to develop methods for quantitative T2* mapping of the developing brain. Brain maturation in the early period of life involves complex structural and physiological changes caused by synaptogenesis, myelination and growth of cells. Molecular structures and biological processes give rise to varying levels of T2* relaxation time, which is an inherent contrast mechanism in magnetic resonance imaging. The knowledge of T2* relaxation times in the brain can thus help with evaluation of pathology by establishing its normative values in the key areas of the brain. T2* relaxation values are a valuable biomarker for myelin microstructure and iron concentration, as well as an important guide towards achievement of optimal fMRI contrast. However, fetal MR imaging is a significant step up from neonatal or adult MR imaging due to the complexity of the acquisition and reconstruction techniques that are required to provide high quality artifact-free images in the presence of maternal respiration and unpredictable fetal motion. The first contribution of this thesis, described in Chapter 4, presents a novel acquisition method for measurement of fetal brain T2* values. At the time of publication, this was the first study of fetal brain T2* values. Single shot multi-echo gradient echo EPI was proposed as a rapid method for measuring fetal T2* values by effectively freezing intra-slice motion. The study concluded that fetal T2* values are higher than those previously reported for pre-term neonates and decline with a consistent trend across gestational age. The data also suggested that longer than usual echo times or direct T2* measurement should be considered when performing fetal fMRI in order to reach optimal BOLD sensitivity. For the second contribution, described in Chapter 5, measurements were extended to a higher field strength of 3T and reported, for the first time, both for fetal and neonatal subjects at this field strength. The technical contribution of this work is a fully automatic segmentation framework that propagates brain tissue labels onto the acquired T2* maps without the need for manual intervention. The third contribution, described in Chapter 6, proposed a new method for performing 3D fetal brain reconstruction where the available data is sparse and is therefore limited in the use of current state of the art techniques for 3D brain reconstruction in the presence of motion. To enable a high resolution reconstruction, a generative adversarial network was trained to perform image to image translation between T2 weighted and T2* weighted data. Translated images could then be served as a prior for slice alignment and super resolution reconstruction of 3D brain image.Open Acces
Multi-shot multi-channel diffusion data recovery using structured low-rank matrix completion
Purpose: To introduce a novel method for the recovery of multi-shot diffusion
weighted (MS-DW) images from echo-planar imaging (EPI) acquisitions.
Methods: Current EPI-based MS-DW reconstruction methods rely on the explicit
estimation of the motion- induced phase maps to recover the unaliased images.
In the new formulation, the k-space data of the unaliased DWI is recovered
using a structured low-rank matrix completion scheme, which does not require
explicit estimation of the phase maps. The structured matrix is obtained as the
lifting of the multi-shot data. The smooth phase-modulations between shots
manifest as null-space vectors of this matrix, which implies that the
structured matrix is low-rank. The missing entries of the structured matrix are
filled in using a nuclear-norm minimization algorithm subject to the
data-consistency. The formulation enables the natural introduction of
smoothness regularization, thus enabling implicit motion-compensated recovery
of fully-sampled as well as under-sampled MS-DW data.
Results: Our experiments on in-vivo data show effective removal of the
ghosting artifacts arising from intershot motion in MS-DW data using the
proposed method. The performance is comparable and better in certain cases than
conventional phase-based methods.
Conclusion: The proposed method can achieve effective unaliasing of
fully/under-sampled MS-DW images without using explicit phase estimates
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