A study to develop neutron activation for measuring bone calcium content

Neutron activation analysis for measuring calcium in monkey bone

Aerospace Medicine and Biology

This bibliography lists 184 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during October 1989. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

High-density diffuse optical tomography for imaging human brain function

This review describes the unique opportunities and challenges for noninvasive optical mapping of human brain function. Diffuse optical methods offer safe, portable, and radiation free alternatives to traditional technologies like positron emission tomography or functional magnetic resonance imaging (fMRI). Recent developments in high-density diffuse optical tomography (HD-DOT) have demonstrated capabilities for mapping human cortical brain function over an extended field of view with image quality approaching that of fMRI. In this review, we cover fundamental principles of the diffusion of near infrared light in biological tissue. We discuss the challenges involved in the HD-DOT system design and implementation that must be overcome to acquire the signal-to-noise necessary to measure and locate brain function at the depth of the cortex. We discuss strategies for validation of the sensitivity, specificity, and reliability of HD-DOT acquired maps of cortical brain function. We then provide a brief overview of some clinical applications of HD-DOT. Though diffuse optical measurements of neurophysiology have existed for several decades, tremendous opportunity remains to advance optical imaging of brain function to address a crucial niche in basic and clinical neuroscience: that of bedside and minimally constrained high fidelity imaging of brain function

Space life sciences: A status report

The scientific research and supporting technology development conducted in the Space Life Sciences Program is described. Accomplishments of the past year are highlighted. Plans for future activities are outlined. Some specific areas of study include the following: Crew health and safety; What happens to humans in space; Gravity, life, and space; Sustenance in space; Life and planet Earth; Life in the Universe; Promoting good science and good will; Building a future for the space life sciences; and Benefits of space life sciences research

Aerospace Medicine and Biology. A continuing bibliography with indexes, supplement 151

This bibliography lists 195 reports, articles, and other documents introduced into the NASA scientific and technical information system in January 1976

Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications.

Quantitative susceptibility mapping (QSM) is a recently developed MRI technique for quantifying the spatial distribution of magnetic susceptibility within biological tissues. It first uses the frequency shift in the MRI signal to map the magnetic field profile within the tissue. The resulting field map is then used to determine the spatial distribution of the underlying magnetic susceptibility by solving an inverse problem. The solution is achieved by deconvolving the field map with a dipole field, under the assumption that the magnetic field is a result of the superposition of the dipole fields generated by all voxels and that each voxel has its unique magnetic susceptibility. QSM provides improved contrast to noise ratio for certain tissues and structures compared to its magnitude counterpart. More importantly, magnetic susceptibility is a direct reflection of the molecular composition and cellular architecture of the tissue. Consequently, by quantifying magnetic susceptibility, QSM is becoming a quantitative imaging approach for characterizing normal and pathological tissue properties. This article reviews the mechanism generating susceptibility contrast within tissues and some associated applications

Doctor of Philosophy

dissertationThis thesis presents the design, fabrication and characterization of a microelectromechanical system (MEMS) based complete wireless microsystem for brain interfacing, with very high quality factor and low power consumption. Components of the neuron sensing system include TiW fixed-fixed bridge resonator, MEMS oscillator based action-potential-to-RF module, and high-efficiency RF coil link for power and data transmissions. First, TiW fixed-fixed bridge resonator on glass substrate was fabricated and characterized, with resonance frequency of 100 - 500 kHz, and a quality factor up to 2,000 inside 10 mT vacuum. The effect of surface conditions on resonator's quality factor was studied with 10s of nm Al2O3 layer deposition with ALD (atomic layer deposition). It was found that MEMS resonator's quality factor decreased with increasing surface roughness. Second, action-potential-to-RF module was realized with MEMS oscillator based on TiW bridge resonator. Oscillation signal with frequency of 442 kHz and phase noise of -84.75 dBc/Hz at 1 kHz offset was obtained. DC biasing of the MEMS oscillator was modulated with neural signal so that the output RF waveform carries the neural signal information. Third, high-efficiency RF coil link for power and data communications was designed and realized. Based on the coupled mode theory (CMT), intermediate resonance coil was introduced and increased voltage transfer efficiency by up to 5 times. Finally, a complete neural interfacing system was demonstrated with board-level integration. The system consists of both internal and external systems, with wireless powering, wireless data transfer, artificial neuron signal generation, neural signal modulation and demodulation, and computer interface displaying restored neuron signal