30,069 research outputs found
Modules and Dialects as Objects in Grace
Grace is a gradually typed, object-oriented language for use in education; consonant with that use, we have tried to keep Grace as simple and straightforward as possible. Grace needs a module system for several reasons: to teach students about modular program design, to organise large programs, especially its self-hosted implementation, to provide access to resources defined in other languages, and to support different âdialectsââlanguage subsets, or domain specific languages, for particular parts of the curriculum. Grace already has several organising constructs; this paper describes how Grace uses two of them, objects and lexical scope, to provide modules and dialects
Variable selection and regression analysis for graph-structured covariates with an application to genomics
Graphs and networks are common ways of depicting biological information. In
biology, many different biological processes are represented by graphs, such as
regulatory networks, metabolic pathways and protein--protein interaction
networks. This kind of a priori use of graphs is a useful supplement to the
standard numerical data such as microarray gene expression data. In this paper
we consider the problem of regression analysis and variable selection when the
covariates are linked on a graph. We study a graph-constrained regularization
procedure and its theoretical properties for regression analysis to take into
account the neighborhood information of the variables measured on a graph. This
procedure involves a smoothness penalty on the coefficients that is defined as
a quadratic form of the Laplacian matrix associated with the graph. We
establish estimation and model selection consistency results and provide
estimation bounds for both fixed and diverging numbers of parameters in
regression models. We demonstrate by simulations and a real data set that the
proposed procedure can lead to better variable selection and prediction than
existing methods that ignore the graph information associated with the
covariates.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS332 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Alberti and Ficino
Leon Battista Alberti and Marsilio Ficino, though separated by twenty-nine years in age, had a close relationship as mentor and pupil. Concepts which can be found in Albertiâs De pictura (1435) and De re aedificatoria (1450) are infused in Ficinoâs De amore (1469). The concepts include Albertiâs theories of armonia, lineamenti, concinnitas, ornamento, and the pyramid of light in the theory of vision. In both Alberti and Ficino, harmonies shared by the body and music are manifestations of the harmonies of the soul. Beauty in body and matter is determined by beauty in mind (mens), that part of mind directed toward intellectus divinus, and beauty is made manifest in mind by the lineamenti, the lines in the mind which are distinguished from matter. Beauty is the internal perfection of the intellectus divinus, which is the good, which is a perfect harmony called concinnitas. Ornament is not beauty, but rather a physical complement to beauty
An instrumental puzzle: the modular integration of AOLI
The Adaptive Optics Lucky Imager, AOLI, is an instrument developed to deliver
the highest spatial resolution ever obtained in the visible, 20 mas, from
ground-based telescopes. In AOLI a new philosophy of instrumental prototyping
has been applied, based on the modularization of the subsystems. This modular
concept offers maximum flexibility regarding the instrument, telescope or the
addition of future developments.Comment: 10 pages, 8 figures, Proc. SPIE 9908, Ground-based and Airborne
Instrumentation for Astronomy VI, 99082Z (August 9, 2016
Advances and visions in large-scale hydrological modelling: findings from the 11th Workshop on Large-Scale Hydrological Modelling
Large-scale hydrological modelling has become increasingly wide-spread during the last decade. An annual workshop series on large-scale hydrological modelling has provided, since 1997, a forum to the German-speaking community for discussing recent developments and achievements in this research area. In this paper we present the findings from the 2007 workshop which focused on advances and visions in large-scale hydrological modelling. We identify the state of the art, difficulties and research perspectives with respect to the themes "sensitivity of model results", "integrated modelling" and "coupling of processes in hydrosphere, atmosphere and biosphere". Some achievements in large-scale hydrological modelling during the last ten years are presented together with a selection of remaining challenges for the future
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