Characterization of the facial phenotype associated with fetal alcohol syndrome using stereo-photogrammetry and geometric morphometrics

Includes abstract.Includes bibliographical references (leaves 108-118).Fetal Alcohol Syndrome (FAS) is a clinical condition caused by excessive pre-natal alcohol exposure and is regarded as a leading identifiable and preventable cause of mental retardation in the Western world. The highest prevalence of FAS was reported in the wine-growing regions of South Africa but data for the rest of the country is not available. Required, therefore, are large-scale screening and surveillance programmes to be conducted in South Africa in order for the epidemiology of the disease to be understood. Efforts to this end have been stymied by the cost and labour-intensive nature of collecting the facial anthropometric data useful in FAS diagnosis. Stereo-photogrammetry provides a low cost, easy to use and non-invasive alternative to traditional facial anthropometry. The design and implementation of a landmark-based stereo-photogrammetry system to obtain 3D facial information for fetal alcohol syndrome diagnosis (FAS) is described. The system consists of three high resolution digital cameras resting on a purpose-built stand and a control frame which surrounds the subject's head during imaging. Reliability and assessments of accuracy for the stereo-photogrammetric tool are presented using 275 inter-landmark distance comparisons between the system and direct anthropometry using a doll. These showed the system to be highly reliable and precise

A quantitative assessment of 3D facial key point localization fitting 2D shape models to curvature information

This work addresses the localization of 11 prominent facial landmarks in 3D by fitting state of the art shape models to 2D data. Quantitative results are provided for 34 scans at high resolution (texture maps of 10 M-pixels) in terms of accuracy (with respect to manual measurements) and precision (repeatability on different images from the same individual). We obtain an average accuracy of approximately 3 mm, and median repeatability of inter-landmark distances typically below 2 mm, which are values comparable to current algorithms on automatic localization of facial landmarks. We also show that, in our experiments, the replacement of texture information by curvature features produced little change in performance, which is an important finding as it suggests the applicability of the method to any type of 3D data

Rotationally invariant 3D shape contexts using asymmetry patterns

This paper presents an approach to resolve the azimuth ambiguity of 3D Shape Contexts (3DSC) based on asymmetry patterns. We show that it is possible to provide rotational invariance to 3DSC at the expense of a marginal increase in computational load, outperforming previous algorithms dealing with the azimuth ambiguity. We build on a recently presented measure of approximate rotational symmetry in 2D defined as the overlapping area between a shape and rotated versions of itself to extract asymmetry patterns from a 3DSC in a variety of ways, depending on the spatial relationships that need to be highlighted or disabled. Thus, we define Asymmetry Patterns Shape Contexts (APSC) from a subset of the possible spatial relations present in the spherical grid of 3DSC; hence they can be thought of as a family of descriptors that depend on the subset that is selected. This provides great flexibility to derive different descriptors. We show that choosing the appropriate spatial patterns can considerably reduce the errors obtained with 3DSC when targeting specific types of points

Automatic classification of facial morphology for medical applications

Facial morphology measurement and classification play important role in the face anthropometry of many medical applications. This usually involves the investigation of medical abnormalities where specific facial features are studied by taking a number of measurements of the facial area under investigation. The measurements are often obtained from the three-dimensional (3D) scans of the faces; however, the measurements are often made manually, which is tedious and time consuming process. Moreover, in gene related studies thousands of measurements may be necessary in order to find statistically significant relationships between facial features and genes. Normative studies, from which typical populous models can be built, also require many measurements. Thus an automatic method to extract morphological measurements and interpret them is desirable. In this article, an automatic method for classification of facial morphology on the basis of a number of geometric measurements obtained automatically from 3D facial scans is presented. Among different facial features the philtrum, which is the vertical groove extending from the nose to the upper lip and the lip area, plays an important role in defining the interaction between the genes and craniofacial anomalies such as, for example, cleft lip and palate. In this paper, geometric features are analysed for their suitability to classify philtrum into three classes previously proposed by medical experts. Moreover, further analysis is conducted to assess the best number of classes to model the underlying data distribution from the point of view of classification accuracy. The obtained classification results are compared with the ground truth manual labelling of 3D face meshes provided by a medical expert. The dataset used for this research is taken from ALSPAC dataset and consists of 1000 3D face meshes. The proposed method achieves classification accuracy of 97% for this data set using the Mean, Minimum and Maximum curvature features in combination