4,497 research outputs found
Sex differences in the adult human brain:Evidence from 5216 UK Biobank participants
Sex differences in the human brain are of interest for many reasons: for example, there are sex differences in the observed prevalence of psychiatric disorders and in some psychological traits that brain differences might help to explain. We report the largest single-sample study of structural and functional sex differences in the human brain (2750 female, 2466 male participants; mean age 61.7 years, range 44–77 years). Males had higher raw volumes, raw surface areas, and white matter fractional anisotropy; females had higher raw cortical thickness and higher white matter tract complexity. There was considerable distributional overlap between the sexes. Subregional differences were not fully attributable to differences in total volume, total surface area, mean cortical thickness, or height. There was generally greater male variance across the raw structural measures. Functional connectome organization showed stronger connectivity for males in unimodal sensorimotor cortices, and stronger connectivity for females in the default mode network. This large-scale study provides a foundation for attempts to understand the causes and consequences of sex differences in adult brain structure and function
The Advantage is at the Ladies: Brain Size Bias-Compensated Graph-Theoretical Parameters are Also Better in Women's Connectomes
In our previous study we have shown that the female connectomes have
significantly better, deep graph-theoretical parameters, related to superior
"connectivity", than the connectome of the males. Since the average female
brain is smaller than the average male brain, one cannot rule out that the
significant advantages are due to the size- and not to the sex-differences in
the data. To filter out the possible brain-volume related artifacts, we have
chosen 36 small male and 36 large female brains such that all the brains in the
female set are larger than all the brains in the male set. For the sets, we
have computed the corresponding braingraphs and computed numerous
graph-theoretical parameters. We have found that (i) the small male brains lack
the better connectivity advantages shown in our previous study for female
brains in general; (ii) in numerous parameters, the connectomes computed from
the large-brain females, still have the significant, deep connectivity
advantages, demonstrated in our previous study.Comment: arXiv admin note: substantial text overlap with arXiv:1501.0072
The Graph of Our Mind
Graph theory in the last two decades penetrated sociology, molecular biology,
genetics, chemistry, computer engineering, and numerous other fields of
science. One of the more recent areas of its applications is the study of the
connections of the human brain. By the development of diffusion magnetic
resonance imaging (diffusion MRI), it is possible today to map the connections
between the 1-1.5 cm regions of the gray matter of the human brain. These
connections can be viewed as a graph: the vertices are the anatomically
identified regions of the gray matter, and two vertices are connected by an
edge if the diffusion MRI-based workflow finds neuronal fiber tracts between
these areas. This way we can compute 1015-vertex graphs with tens of thousands
of edges. In a previous work, we have analyzed the male and female braingraphs
graph-theoretically, and we have found statistically significant differences in
numerous parameters between the sexes: the female braingraphs are better
expanders, have more edges, larger bipartition widths, and larger vertex cover
than the braingraphs of the male subjects. Our previous study has applied the
data of 96 subjects; here we present a much larger study of 426 subjects. Our
data source is an NIH-founded project, the "Human Connectome Project (HCP)"
public data release. As a service to the community, we have also made all of
the braingraphs computed by us from the HCP data publicly available at the
\url{http://braingraph.org} for independent validation and further
investigations.Comment: arXiv admin note: substantial text overlap with arXiv:1512.01156,
arXiv:1501.0072
Structural subnetwork evolution across the life-span: rich-club, feeder, seeder
The impact of developmental and aging processes on brain connectivity and the
connectome has been widely studied. Network theoretical measures and certain
topological principles are computed from the entire brain, however there is a
need to separate and understand the underlying subnetworks which contribute
towards these observed holistic connectomic alterations. One organizational
principle is the rich-club - a core subnetwork of brain regions that are
strongly connected, forming a high-cost, high-capacity backbone that is
critical for effective communication in the network. Investigations primarily
focus on its alterations with disease and age. Here, we present a systematic
analysis of not only the rich-club, but also other subnetworks derived from
this backbone - namely feeder and seeder subnetworks. Our analysis is applied
to structural connectomes in a normal cohort from a large, publicly available
lifespan study. We demonstrate changes in rich-club membership with age
alongside a shift in importance from 'peripheral' seeder to feeder subnetworks.
Our results show a refinement within the rich-club structure (increase in
transitivity and betweenness centrality), as well as increased efficiency in
the feeder subnetwork and decreased measures of network integration and
segregation in the seeder subnetwork. These results demonstrate the different
developmental patterns when analyzing the connectome stratified according to
its rich-club and the potential of utilizing this subnetwork analysis to reveal
the evolution of brain architectural alterations across the life-span
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