The CLIC Programme: Towards a Staged e+e- Linear Collider Exploring the Terascale : CLIC Conceptual Design Report

This report describes the exploration of fundamental questions in particle physics at the energy frontier with a future TeV-scale e+e- linear collider based on the Compact Linear Collider (CLIC) two-beam acceleration technology. A high-luminosity high-energy e+e- collider allows for the exploration of Standard Model physics, such as precise measurements of the Higgs, top and gauge sectors, as well as for a multitude of searches for New Physics, either through direct discovery or indirectly, via high-precision observables. Given the current state of knowledge, following the observation of a 125 GeV Higgs-like particle at the LHC, and pending further LHC results at 8 TeV and 14 TeV, a linear e+e- collider built and operated in centre-of-mass energy stages from a few-hundred GeV up to a few TeV will be an ideal physics exploration tool, complementing the LHC. In this document, an overview of the physics potential of CLIC is given. Two example scenarios are presented for a CLIC accelerator built in three main stages of 500 GeV, 1.4 (1.5) TeV, and 3 TeV, together with operating schemes that will make full use of the machine capacity to explore the physics. The accelerator design, construction, and performance are presented, as well as the layout and performance of the experiments. The proposed staging example is accompanied by cost estimates of the accelerator and detectors and by estimates of operating parameters, such as power consumption. The resulting physics potential and measurement precisions are illustrated through detector simulations under realistic beam conditions.Comment: 84 pages, published as CERN Yellow Report https://cdsweb.cern.ch/record/147522

Efficient implementation of video processing algorithms on FPGA

The work contained in this portfolio thesis was carried out as part of an Engineering Doctorate (Eng.D) programme from the Institute for System Level Integration. The work was sponsored by Thales Optronics, and focuses on issues surrounding the implementation of video processing algorithms on field programmable gate arrays (FPGA). A description is given of FPGA technology and the currently dominant methods of designing and verifying firmware. The problems of translating a description of behaviour into one of structure are discussed, and some of the latest methodologies for tackling this problem are introduced. A number of algorithms are then looked at, including methods of contrast enhancement, deconvolution, and image fusion. Algorithms are characterised according to the nature of their execution flow, and this is used as justification for some of the design choices that are made. An efficient method of performing large two-dimensional convolutions is also described. The portfolio also contains a discussion of an FPGA implementation of a PID control algorithm, an overview of FPGA dynamic reconfigurability, and the development of a demonstration platform for rapid deployment of video processing algorithms in FPGA hardware

State Estimation for Distributed and Hybrid Systems

This thesis deals with two aspects of recursive state estimation: distributed estimation and estimation for hybrid systems. In the first part, an approximate distributed Kalman filter is developed. Nodes update their state estimates by linearly combining local measurements and estimates from their neighbors. This scheme allows nodes to save energy, thus prolonging their lifetime, compared to centralized information processing. The algorithm is evaluated experimentally as part of an ultrasound based positioning system. The first part also contains an example of a sensor-actuator network, where a mobile robot navigates using both local sensors and information from a sensor network. This system was implemented using a component-based framework. The second part develops, a recursive joint maximum a posteriori state estimation scheme for Markov jump linear systems. The estimation problem is reformulated as dynamic programming and then approximated using so called relaxed dynamic programming. This allows the otherwise exponential complexity to be kept at manageable levels. Approximate dynamic programming is also used to develop a sensor scheduling algorithm for linear systems. The algorithm produces an offline schedule that when used together with a Kalman filter minimizes the estimation error covariance

Modelling of the downstream processing of a recombinant intracellular enzyme

This thesis examines the generation and verification of robust and predictive models for key unit operations in the downstream processing of a recombinant intracellular enzyme. Computer models are becoming increasingly used in the biotechnology industry to assess process feasibility, ensure appropriate specification and achieve efficient operation of bioprocesses. With increasing pressure to bring bioproducts to market in the shortest possible time and at low cost, it is essential that these models can be generated early in the development cycle with a minimum of time and expense. Regulatory concerns over the use of recombinant systems also require a highly consistent product and a large degree of confidence in any final design. Models must therefore be verified against real process data in order to demonstrate and improve their validity. The specific operations under study were cell disruption by high pressure homogenisation, enzyme fractionation and concentration by ammonium sulphate precipitation, and cell harvesting, debris removal and precipitate separation by disc stack centrifugation. Existing models based on the recovery of alcohol dehydrogenase (ADH) from natural bakers' yeast were applied to the processing of a protein engineered form of the enzyme (pe-ADH) and their validity assessed by comparison with experimental data obtained from small amounts of fermented recombinant material. Differences were observed in the processing of the natural and protein engineered enzyme and, although parameter re-evaluation was generally required to maintain model accuracy, the models were found to be generic in nature. Individual unit models were then arranged and linked in a modular fashion to produce a whole process model. Verification of the process model based on recombinant system parameters against pilot-scale data showed sufficient accuracy for use in feasibility studies (±30%). The inability to describe precipitant breakage in the disc stack centrifuge feed-zone was the major source of model inaccuracy. The work highlighted the utility of scale-down systems as an aid to rapid and cost- effective model development. The importance of experimental verification in order to provide confidence in model accuracy and scalability was stressed, as was the need for modelling to be an integrated activity during bioprocess development

Radar Technology

In this book “Radar Technology”, the chapters are divided into four main topic areas: Topic area 1: “Radar Systems” consists of chapters which treat whole radar systems, environment and target functional chain. Topic area 2: “Radar Applications” shows various applications of radar systems, including meteorological radars, ground penetrating radars and glaciology. Topic area 3: “Radar Functional Chain and Signal Processing” describes several aspects of the radar signal processing. From parameter extraction, target detection over tracking and classification technologies. Topic area 4: “Radar Subsystems and Components” consists of design technology of radar subsystem components like antenna design or waveform design

Intensity modulated radiation therapy and arc therapy: validation and evolution as applied to tumours of the head and neck, abdominal and pelvic regions

Intensiteitsgemoduleerde radiotherapie (IMRT) laat een betere controle over de dosisdistributie (DD) toe dan meer conventionele bestralingstechnieken. Zo is het met IMRT mogelijk om concave DDs te bereiken en om de risico-organen conformeel uit te sparen. IMRT werd in het UZG klinisch toegepast voor een hele waaier van tumorlocalisaties. De toepassing van IMRT voor de bestraling van hoofd- en halstumoren (HHT) vormt het onderwerp van het eerste deel van deze thesis. De planningsstrategie voor herbestralingen en bestraling van HHT, uitgaande van de keel en de mondholte wordt beschreven, evenals de eerste klinische resultaten hiervan. IMRT voor tumoren van de neus(bij)holten leidt tot minstens even goede lokale controle (LC) en overleving als conventionele bestralingstechnieken, en dit zonder stralingsgeïnduceerde blindheid. IMRT leidt dus tot een gunstiger toxiciteitprofiel maar heeft nog geen bewijs kunnen leveren van een gunstig effect op LC of overleving. De meeste hervallen van HHT worden gezien in het gebied dat tot een hoge dosis bestraald werd, wat erop wijst dat deze “hoge dosis” niet volstaat om alle clonogene tumorcellen uit te schakelen. We startten een studie op, om de mogelijkheid van dosisescalatie op geleide van biologische beeldvorming uit te testen. Naast de toepassing en klinische validatie van IMRT bestond het werk in het kader van deze thesis ook uit de ontwikkeling en het klinisch opstarten van intensiteitgemoduleerde arc therapie (IMAT). IMAT is een rotationele vorm van IMRT (d.w.z. de gantry draait rond tijdens de bestraling), waarbij de modulatie van de intensiteit bereikt wordt door overlappende arcs. IMAT heeft enkele duidelijke voordelen ten opzichte van IMRT in bepaalde situaties. Als het doelvolume concaaf rond een risico-orgaan ligt met een grote diameter, biedt IMAT eigenlijk een oneindig aantal bundelrichtingen aan. Een planningsstrategie voor IMAT werd ontwikkeld, en type-oplossingen voor totaal abdominale bestraling en rectumbestraling werden onderzocht en klinisch toegepast