The "MIND" Scalable PIM Architecture

MIND (Memory, Intelligence, and Network Device) is an advanced parallel computer architecture for high performance computing and scalable embedded processing. It is a Processor-in-Memory (PIM) architecture integrating both DRAM bit cells and CMOS logic devices on the same silicon die. MIND is multicore with multiple memory/processor nodes on each chip and supports global shared memory across systems of MIND components. MIND is distinguished from other PIM architectures in that it incorporates mechanisms for efficient support of a global parallel execution model based on the semantics of message-driven multithreaded split-transaction processing. MIND is designed to operate either in conjunction with other conventional microprocessors or in standalone arrays of like devices. It also incorporates mechanisms for fault tolerance, real time execution, and active power management. This paper describes the major elements and operational methods of the MIND architecture

Language independent modelling of parallelism

To make programs work in parallel contexts without any hazards, programming languages require changes to their structures and compilers. One of the most complicated parts is memory models and how programming languages deal with memory interactions. Different processors provide a different level of safety guarantees (i.e. ARM provides relaxed whereas Intel provides strong guarantees). On the other hand, different programming languages provide different structures for parallel computation and have individual protocols for communicating with parallel processes. Unfortunately, no specific choice is best in all situations. This thesis focuses on memory models of various programming languages and processors highlighting some positive and negative features from the point of view of programmability, performance and portability. In order to give some evidence of problems and performance bottlenecks, some small programs have been developed. This thesis also concentrates on incorrect behaviors, especially on data race conditions in programs, providing suggestions on how to avoid them. Also, some litmus tests on systems featuring different vendors' processors were performed to observe data races on each system. Nowadays programming paradigms also became a big issue. Some of the programming styles support observable non-determinism which is the main reason for incorrect behavior in programs. In this thesis, different programming models are also discussed based on the current state of the available research. Also, the imperative and functional paradigms in different contexts are compared. Finally, a mathematical problem was solved using two different paradigms to provide some practical evidence of the theory

Proceedings of the Second International Workshop on Sustainable Ultrascale Computing Systems (NESUS 2015) Krakow, Poland

Proceedings of: Second International Workshop on Sustainable Ultrascale Computing Systems (NESUS 2015). Krakow (Poland), September 10-11, 2015

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a human stem cell differentiation model, we identify two clusters of enhancers within the PRS-associated region that regulate SOX9 expression during a restricted window of facial progenitor development at distances up to 1.45 Mb. Enhancers within the 1.45 Mb cluster exhibit highly synergistic activity that is dependent on the Coordinator motif. Using mouse models, we demonstrate that PRS phenotypic specificity arises from the convergence of two mechanisms: confinement of Sox9 dosage perturbation to developing facial structures through context-specific enhancer activity and heightened sensitivity of the lower jaw to Sox9 expression reduction. Overall, we characterize the longest-range human enhancers involved in congenital malformations, directly demonstrate that PRS is an enhanceropathy, and illustrate how small changes in gene expression can lead to morphological variation

Parallel evolution strategy for protein threading.

A protein-sequence folds into a specific shape in order to function in its aqueous state. If the primary sequence of a protein is given, what is its three dimensional structure? This is a long-standing problem in the field of molecular biology and it has large implication to drug design and cure. Among several proposed approaches, protein threading represents one of the most promising technique. The protein threading problem (PTP) is the problem of determining the three-dimensional structure of a given but arbitrary protein sequence from a set of known structures of other proteins. This problem is known to be NP-hard and current computational approaches to threading are time-consuming and data-intensive. In this thesis, we proposed an evolution strategy (ES) based approach for protein threading (EST). We also developed two parallel approaches for the PTP problem and both are parallelizations of our novel EST. The first method, we call SQST-PEST (Single Query Single Template Parallel EST) threads a single query against a single template. We use ES to find the best alignment between the query and the template, and ES is parallelized. The second method, we call SQMT-PEST (Single Query Multiple Templates Parallel EST) to allow for threading a single query against multiple templates within reasonable time. We obtained better results than current comparable approaches, as well as significant reduction in execution time.Dept. of Computer Science. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2005 .I85. Source: Masters Abstracts International, Volume: 44-03, page: 1403. Thesis (M.Sc.)--University of Windsor (Canada), 2005

On the design of architecture-aware algorithms for emerging applications

This dissertation maps various kernels and applications to a spectrum of programming models and architectures and also presents architecture-aware algorithms for different systems. The kernels and applications discussed in this dissertation have widely varying computational characteristics. For example, we consider both dense numerical computations and sparse graph algorithms. This dissertation also covers emerging applications from image processing, complex network analysis, and computational biology. We map these problems to diverse multicore processors and manycore accelerators. We also use new programming models (such as Transactional Memory, MapReduce, and Intel TBB) to address the performance and productivity challenges in the problems. Our experiences highlight the importance of mapping applications to appropriate programming models and architectures. We also find several limitations of current system software and architectures and directions to improve those. The discussion focuses on system software and architectural support for nested irregular parallelism, Transactional Memory, and hybrid data transfer mechanisms. We believe that the complexity of parallel programming can be significantly reduced via collaborative efforts among researchers and practitioners from different domains. This dissertation participates in the efforts by providing benchmarks and suggestions to improve system software and architectures.Ph.D.Committee Chair: Bader, David; Committee Member: Hong, Bo; Committee Member: Riley, George; Committee Member: Vuduc, Richard; Committee Member: Wills, Scot

Graph analytics on modern massively parallel systems

Graphs provide a very flexible abstraction for understanding and modeling complex systems in many fields such as physics, biology, neuroscience, engineering, and social science. Only in the last two decades, with the advent of Big Data era, supercomputers equipped by accelerators –i.e., Graphics Processing Unit (GPUs)–, advanced networking, and highly parallel file systems have been used to analyze graph properties such as reachability, diameter, connected components, centrality, and clustering coefficient. Today graphs of interest may be composed by millions, sometimes billions, of nodes and edges and exhibit a highly irregular structure. As a consequence, the design of efficient and scalable graph algorithms is an extraordinary challenge due to irregular communication and memory access patterns, high synchronization costs, and lack of data locality. In the present dissertation, we start off with a brief and gentle introduction for the reader to graph analytics and massively parallel systems. In particular, we present the intersection between graph analytics and parallel architectures in the current state-of-the-art and discuss the challenges encountered when solving such problems on large-scale graphs on these architectures (Chapter 1). In Chapter 2, some preliminary definitions and graph-theoretical notions are provided together with a description of the synthetic graphs used in the literature to model real-world networks. In Chapters 3-5, we present and tackle three different relevant problems in graph analysis: reachability (Chapter 3), Betweenness Centrality (Chapter 4), and clustering coefficient (Chapter 5). In detail, Chapter 3 tackles reachability problems by providing two scalable algorithms and implementations which efficiently solve st-connectivity problems on very large-scale graphs Chapter 4 considers the problem of identifying most relevant nodes in a network which plays a crucial role in several applications, including transportation and communication networks, social network analysis, and biological networks. In particular, we focus on a well-known centrality metrics, namely Betweenness Centrality (BC), and present two different distributed algorithms for the BC computation on unweighted and weighted graphs. For unweighted graphs, we present a new communication-efficient algorithm based on the combination of bi-dimensional (2D) decomposition and multi-level parallelism. Furthermore, new algorithms which exploit the underlying graph topology to reduce the time and space usage of betweenness centrality computations are described as well. Concerning weighted graphs, we provide a scalable algorithm based on an algebraic formulation of the problem. Finally, thorough comprehensive experimental results on synthetic and real- world large-scale graphs, we show that the proposed techniques are effective in practice and achieve significant speedups against state-of-the-art solutions. Chapter 5 considers clustering coefficients problem. Similarly to Betweenness Centrality, it is a fundamental tool in network analysis, as it specifically measures how nodes tend to cluster together in a network. In the chapter, we first extend caching techniques to Remote Memory Access (RMA) operations on distributed-memory system. The caching layer is mainly designed to avoid inter-node communications in order to achieve similar benefits for irregular applications as communication-avoiding algorithms. We also show how cached RMA is able to improve the performance of a new distributed asynchronous algorithm for the computation of local clustering coefficients. Finally, Chapter 6 contains a brief summary of the key contributions described in the dissertation and presents potential future directions of the work