15 research outputs found

    Combined Diffusion-Relaxometry MRI to Identify Dysfunction in the Human Placenta

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    Purpose: A combined diffusion-relaxometry MR acquisition and analysis pipeline for in-vivo human placenta, which allows for exploration of coupling between T2* and apparent diffusion coefficient (ADC) measurements in a sub 10 minute scan time. Methods: We present a novel acquisition combining a diffusion prepared spin-echo with subsequent gradient echoes. The placentas of 17 pregnant women were scanned in-vivo, including both healthy controls and participants with various pregnancy complications. We estimate the joint T2*-ADC spectra using an inverse Laplace transform. Results: T2*-ADC spectra demonstrate clear quantitative separation between normal and dysfunctional placentas. Conclusions: Combined T2*-diffusivity MRI is promising for assessing fetal and maternal health during pregnancy. The T2*-ADC spectrum potentially provides additional information on tissue microstructure, compared to measuring these two contrasts separately. The presented method is immediately applicable to the study of other organs

    The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: An MRI study

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    KEY POINTS: Maternal supine sleep position in late pregnancy is associated with an increased risk of stillbirth. Maternal supine position in late pregnancy reduces maternal cardiac output and uterine blood flow. Using MRI, this study shows that compared to the left lateral position, maternal supine position in late pregnancy is associated with reduced uteroplacental blood flow, oxygen transfer across the placenta with an average 6.2% reduction in oxygen delivery to the fetus and an average 11% reduction in fetal umbilical venous blood flow. ABSTRACT: Maternal sleep position in late gestation is associated with an increased risk of stillbirth though the pathophysiological reasons for this are unclear. Studies using MRI have shown that compared with lateral positions, lying supine causes a reduction in cardiac output, reduced abdominal aortic blood flow and reduced vena caval flow which is only partially compensated for by increased flow in the azygos venous system. Using functional MRI techniques, including an acquistion termed Diffusion-Relaxation Combined Imaging of the Placenta (DECIDE), which combines diffusion weighted imaging and T2 relaxometry, blood flow and oxygen transfer were estimated in the maternal, fetal and placental compartments when subjects were scanned both supine and in left lateral positions. In late gestation pregnancy, lying supine caused a 23.7% (p <0.0001) reduction in total internal iliac arterial blood flow to the uterus. In addition, lying in the supine position caused a 6.2% (p = 0.038) reduction in oxygen movement across the placenta. The reductions in oxygen transfer to the fetus, termed delivery flux, of 11.2% (p = 0.0597) and in fetal oxygen saturation of 4.4% (p = 0.0793) did not reach statistical significance. It is concluded that even in healthy late gestation pregnancy, maternal position significantly affects oxygen transfer across the placenta and may in part provide an explanation for late stillbirth in vulnerable fetuses. This article is protected by copyright. All rights reserved

    MRI of foetal development

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    Foetal MRI represents a non-invasive imaging technique that allows detailed visualisation of foetus in utero and the maternal structure. This thesis outlines the quantitative imaging techniques used to investigate the effect of maternal diabetes and maternal smoking on foetal development at 1.5 Tesla. The effect of maternal diabetes on placental blood flow and foetal growth was studied. The placental images were acquired using Echo Planar Imaging and blood flow was measured using Intra Voxel Incoherent Motion. The results indicate that peak blood flow in the basal plate and chorionic plate increases across gestation in both normal and diabetic pregnancies. Conversely, diffusion in the whole placenta decreases across gestation, with a more pronounced decrease in diabetic placentae. Following this, a method was developed to use a Tl weighted fat suppressed MRI scan to quantify foetal fat images in-utero. In addition, HAlf Fourier Single-shot Turbo spin Echo (HASTE) and balanced Fast Field Echo (bFFE) were used to acquire images encompassing the whole foetus in three orthogonal planes. These scans were used to measure foetal volume, foetal length and shoulder width. The data shows that foetal fat volume and intra-abdominal fat were increased in foetuses of diabetic mothers at third trimester. The HASTE and bFFE sequences were also used to study the effect of maternal smoking on foetal development. Here, foetal organ volumes, foetal and placental volume, shoulder width and foetal length were measured using a semiautomatic approach based on the concept of edge detection and a stereological method, the Cavalieri technique. The data shows that maternal smoking has significant negative effect on foetal organ growth and foetal growth, predominantly foetal kidney and foetal volume. The work described here certainly has a great potential in non-invasive assessment of abnormal placental function and can be used to study foetal development

    Anisotropy Across Fields and Scales

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    This open access book focuses on processing, modeling, and visualization of anisotropy information, which are often addressed by employing sophisticated mathematical constructs such as tensors and other higher-order descriptors. It also discusses adaptations of such constructs to problems encountered in seemingly dissimilar areas of medical imaging, physical sciences, and engineering. Featuring original research contributions as well as insightful reviews for scientists interested in handling anisotropy information, it covers topics such as pertinent geometric and algebraic properties of tensors and tensor fields, challenges faced in processing and visualizing different types of data, statistical techniques for data processing, and specific applications like mapping white-matter fiber tracts in the brain. The book helps readers grasp the current challenges in the field and provides information on the techniques devised to address them. Further, it facilitates the transfer of knowledge between different disciplines in order to advance the research frontiers in these areas. This multidisciplinary book presents, in part, the outcomes of the seventh in a series of Dagstuhl seminars devoted to visualization and processing of tensor fields and higher-order descriptors, which was held in Dagstuhl, Germany, on October 28–November 2, 2018

    Anisotropy Across Fields and Scales

    Get PDF
    This open access book focuses on processing, modeling, and visualization of anisotropy information, which are often addressed by employing sophisticated mathematical constructs such as tensors and other higher-order descriptors. It also discusses adaptations of such constructs to problems encountered in seemingly dissimilar areas of medical imaging, physical sciences, and engineering. Featuring original research contributions as well as insightful reviews for scientists interested in handling anisotropy information, it covers topics such as pertinent geometric and algebraic properties of tensors and tensor fields, challenges faced in processing and visualizing different types of data, statistical techniques for data processing, and specific applications like mapping white-matter fiber tracts in the brain. The book helps readers grasp the current challenges in the field and provides information on the techniques devised to address them. Further, it facilitates the transfer of knowledge between different disciplines in order to advance the research frontiers in these areas. This multidisciplinary book presents, in part, the outcomes of the seventh in a series of Dagstuhl seminars devoted to visualization and processing of tensor fields and higher-order descriptors, which was held in Dagstuhl, Germany, on October 28–November 2, 2018

    Magnetic Resonance Imaging of the Brain in Moving Subjects. Application of Fetal, Neonatal and Adult Brain Studies

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    Imaging in the presence of subject motion has been an ongoing challenge for magnetic resonance imaging (MRI). Motion makes MRI data inconsistent, causing artifacts in conventional anatomical imaging as well as invalidating diffusion tensor imaging (DTI) reconstruction. In this thesis some of the important issues regarding the acquisition and reconstruction of anatomical and DTI imaging of moving subjects are addressed; methods to achieve high resolution and high signalto- noise ratio (SNR) volume data are proposed. An approach has been developed that uses multiple overlapped dynamic single shot slice by slice imaging combined with retrospective alignment and data fusion to produce self consistent 3D volume images under subject motion. We term this method as snapshot MRI with volume reconstruction or SVR. The SVR method has been performed successfully for brain studies on subjects that cannot stay still, and in some cases were moving substantially during scanning. For example, awake neonates, deliberately moved adults and, especially, on fetuses, for which no conventional high resolution 3D method is currently available. Fine structure of the in-utero fetal brain is clearly revealed for the first time with substantially improved SNR. The SVR method has been extended to correct motion artifacts from conventional multi-slice sequences when the subject drifts in position during data acquisition. Besides anatomical imaging, the SVR method has also been further extended to DTI reconstruction when there is subject motion. This has been validated successfully from an adult who was deliberately moving and then applied to inutero fetal brain imaging, which no conventional high resolution 3D method is currently available. Excellent fetal brain 3D apparent diffusion coefficient (ADC) maps in high resolution have been achieved for the first time as well as promising fractional Anisotropy (FA) maps. Pilot clinical studies using SVR reconstructed data to study fetal brain development in-utero have been performed. Growth curves for the normally developing fetal brain have been devised by the quantification of cerebral and cerebellar volumes as well as some one dimensional measurements. A Verhulst model is proposed to describe these growth curves, and this approach has achieved a correlation over 0.99 between the fitted model and actual data

    Intelligent Imaging of Perfusion Using Arterial Spin Labelling

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    Arterial spin labelling (ASL) is a powerful magnetic resonance imaging technique, which can be used to noninvasively measure perfusion in the brain and other organs of the body. Promising research results show how ASL might be used in stroke, tumours, dementia and paediatric medicine, in addition to many other areas. However, significant obstacles remain to prevent widespread use: ASL images have an inherently low signal to noise ratio, and are susceptible to corrupting artifacts from motion and other sources. The objective of the work in this thesis is to move towards an "intelligent imaging" paradigm: one in which the image acquisition, reconstruction and processing are mutually coupled, and tailored to the individual patient. This thesis explores how ASL images may be improved at several stages of the imaging pipeline. We review the relevant ASL literature, exploring details of ASL acquisitions, parameter inference and artifact post-processing. We subsequently present original work: we use the framework of Bayesian experimental design to generate optimised ASL acquisitions, we present original methods to improve parameter inference through anatomically-driven modelling of spatial correlation, and we describe a novel deep learning approach for simultaneous denoising and artifact filtering. Using a mixture of theoretical derivation, simulation results and imaging experiments, the work in this thesis presents several new approaches for ASL, and hopefully will shape future research and future ASL usage

    Infective/inflammatory disorders

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    The radiological investigation of musculoskeletal tumours : chairperson's introduction

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